Light-green and deep-red luminescent semiconductor nanocrystals as bio-imaging ag

作为生物成像载体的浅绿色和深红色发光半导体纳米晶体

• 批准号: 7532840
• 负责人: YUNJUN WANG
• 金额: $ 10万
• 依托单位: MESOLIGHT, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7532840
• 关键词: Biological; Cadmium; Cells; Dyes; Electromagnetics; Elements; Exhibits; Heavy Metals; Human; Image; Ions; Label; Life; Ligands; Light; Methyl Green; Phase; Polymers; Production; Quantum Dots; Reporting; Research; Science; Semiconductors; Small Business Innovation Research Grant; Surface; Toxic effect; United States National Institutes of Health; Water; Work; base; bioimaging; luminescence; monolayer; nanocrystal; particle; programs; public health relevance; surface coating

DESCRIPTION (provided by applicant): Semiconductor nanocrystals (quantum dots), specifically CdS, CdSe and CdTe, etc, have been extensively studied in the past two decades, leading to their integration in light emitting diodes (LEDs), solar cell, and bio-imaging/labeling. Although efficient deep-green, yellow, and red emissions have been realized with these nanocrystals, but quantum dots with light-green and deep-red emissions have remained elusive due to a lack of appropriate materials. Meanwhile, the intrinsic toxicity of these cadmium-containing nanocrystals is also a concern and may eventually limit many of their potential applications (specifically in human related subjects). This NIH SBIR project will develop highly bright and stable light-green and deep-red emitting quantum dots that can be used as bio-imaging agents. The proposed quantum dots contain no cadmium or other heavy metal elements, and thus would find wide applications in life and biomedical sciences. Key words: Semiconductor nanocrystals, cadmium-free quantum dots, nanocrystal production, doped nanocrystals, light-green emitting quantum dots, deep-red emitting quantum dots. PUBLIC HEALTH RELEVANCE: This SBIR project will develop highly bright and stable light-green and deep-red ZnTe based luminescent quantum dots that can be used for bioimaging application.

描述（由申请人提供）：半导体纳米晶体（量子点），特别是CdS、CdSe和CdTe等，在过去的二十年中得到了广泛的研究，导致它们集成在发光二极管（LED）、太阳能电池和生物成像/标记中。虽然这些纳米晶体已经实现了高效的深绿色，黄色和红色发射，但由于缺乏合适的材料，具有浅绿色和深红色发射的量子点仍然难以捉摸。同时，这些含镉纳米晶体的内在毒性也是一个问题，并可能最终限制其许多潜在的应用（特别是在人类相关的主题）。这个NIH SBIR项目将开发高度明亮和稳定的浅绿色和深红色发光量子点，可用作生物成像剂。所提出的量子点不含镉或其他重金属元素，因此将在生命和生物医学科学中找到广泛的应用。关键词：半导体奈米晶体、无镉量子点、光量子点制造、掺杂奈米晶体、浅绿色量子点、深红色量子点。 公共卫生关系：该SBIR项目将开发高亮度和稳定的浅绿色和深红色ZnTe基发光量子点，可用于生物成像应用。