Infection resistent coatings for mechanical circulatory support systems (MCSS)

描述(由申请人提供)：使用体外循环和植入性机械循环支持系统(MCSS)带来的感染风险很高，继续造成严重的临床并发症。在这个第一阶段的提案中，Ension将开发和评估一种生物集成表面涂层的可行性，该涂层可应用于可植入设备、套管和传动系。拟议的表面修饰将包括一层用于防止细菌粘连的表层和一层近乎自然的胶原层，胶原层将有利于正常的愈合反应，而不是形成可能损害免疫功能的厚厚的纤维囊膜。此外，拟议的工程表面将服从于加入抗菌剂，随着时间的推移将以受控的方式释放。拟议的第一阶段SBIR的目标是开发和证明抗感染表面的可行性，目的是减少机械循环支持的感染相关并发症。公共卫生相关性：这项研究的产品是一种抗感染的表面涂层，适用于任何通过有感染风险的人体皮肤的医疗器械。这包括人工器官、插管、瘘管和导管的表面和经皮组件。

DESCRIPTION (provided by applicant): The high risk of infection posed by the use of paracorporeal and implanted mechanical circulatory support systems (MCSS) continues to create significant clinical complications. In this Phase I proposal, Ension will develop and assess the feasibility of a biointegrative surface coating that can be applied to implantable devices, cannulae, and drivelines. The proposed surface modification will consist of a surface layer formulated to prevent bacterial adhesion and a grafted near natural layer of collagen that will favor a normal healing response over the formation of a thick, fibrous capsule that can compromise immune function. In addition, the proposed engineered surface will be amenable to incorporating an antimicrobial that will release in a controlled manner over time. The goal of the proposed Phase I SBIR is to develop and demonstrate the feasibility of an infection resistant surface with the aim of reducing infection related complications of mechanical circulatory support. PUBLIC HEALTH RELEVANCE: The product of this research, an infection resistant surface coating, has application to any medical apparatus that passes through human skin at risk for infection. This includes the surfaces and transcutaneous component of artificial organs, cannula, fistula, and catheters.