Collaborative Observational Study of Myopia in Comet Children

彗星儿童近视的合作观察研究

• 批准号: 7893441
• 负责人: MITCHELL M SCHEIMAN
• 金额: $ 6.64万
• 依托单位: SALUS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893441
• 关键词: 11 year old; 16 year old; 17 year old; 7 year old; Address; Adolescent; Adult; African American; Age; Blindness; Child; Clinical; Cohort Studies; Contact Lenses; Cornea; Data; Development; Documentation; Enrollment; Environmental Risk Factor; Equipment; Esophoria; Ethnic Origin; Eye; Future; Genetic; Glass; Growth; High Prevalence; Hispanics; Hour; Human Resources; Intervention; Learning; Literature; Manuals; Measurement; Modeling; Myopia; Observational Study; Occupational; Operative Surgical Procedures; Optometry; Parents; Participant; Pathology; Patients; Pennsylvania; Physiologic Intraocular Pressure; Population; Predictive Factor; Procedures; Protocols documentation; Public Health; Refractive Errors; Risk; Risk Factors; Subgroup; Testing; Thick; Time; Vision; Work; base; cohort; college; follow-up; macula; predictive modeling; response

DESCRIPTION (provided by applicant): This proposal is for the Pennsylvania College of Optometry Clinical Center to continue to annually examine the 93 currently enrolled COSMICC participants (only 15 subjects have been lost to follow-up since enrolled in 1997-98) at the Pennsylvania College of Optometry center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment. This application documents the Pennsylvania College of Optometry's ability to follow the COSMICC2 Manual of Procedures and to retain patients for five years. Documentation is also provided that the Pennsylvania College of Optometry has the personnel, equipment, and facilities to conduct the study in accordance with the COSMICC2 Manual of Procedures.

描述（由申请人提供）：本提案旨在根据COSMICC 2方案，继续每年在宾夕法尼亚大学视光学中心对93名目前入组的COSMICC参与者（自1997-98年入组以来，仅15名受试者失访）进行额外5年（总随访时间为14年）的检查。从该中心收集的数据将用于解决在主席申请中更详细描述的具体目标，并在此简要总结：1）使用数学函数（Gompertz函数和其他），以模拟58%的COSMICC进展性近视受试者的近视进展，并基于先前确定的风险因素开发预测模型和检验假设（年龄、种族、父母近视）; 2）在该充分表征的近视患者队列中检验与近视进展和稳定以及轴向延长的环境风险因素相关的4个假设;以及3）检验与COSMICC受试者中IOP、CCT和黄斑厚度的近视相关变化的发展的风险因素相关的3个假设。近视的高患病率（占美国成年人口的25%）及其作为公共卫生问题（可导致视力丧失和失明的风险因素）的突出性强调了增加对进展和最终稳定的潜在机制的理解的重要性，以便将来近视可能限于低水平。更好地了解预测近视进展和稳定的因素也将有助于指导干预措施的选择和时机，并针对那些可能从治疗中受益最多的群体。本申请记录了宾夕法尼亚大学视光学院遵循COSMICC 2程序手册并保留患者五年的能力。还提供了宾夕法尼亚验光学院拥有按照COSMICC 2程序手册进行研究的人员、设备和设施的文件。