Cancer and Leukemia Group B

癌症和白血病 B 组

基本信息

  • 批准号:
    7892673
  • 负责人:
  • 金额:
    $ 20.14万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-06-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Provided by applicant): The CALGB is comprised of 26 academic medical centers and over 200 affiliated community hospitals joined in the pursuit of improved cancer treatment and better understanding of tumor biology and cancer treatment outcomes via the conduct of controlled clinical trials. Over 4,000 members of the Group including oncology physicians, radiologists, pathologists, statisticians, clinical research associates, oncology nurses, pharmacists, health outcomes researchers, and basic scientists participate in these studies. From 25-30 phase III protocols are active at any one time, along with phase II and phase I studies that provide preliminary data required for the appropriate design of large scale randomized trials. Multidisciplinary disease committees of the Group design and implement protocols for the treatment of patients with leukemia, lymphoma, breast, respiratory, Gl and GU cancer. Modality committees, including Leukemia Correlative Sciences, Imaging, Pharmacology and Experimental Therapeutics, Surgery, Transplant, Cancer in the Elderly, Cancer Control and Health Outcomes, and Oncology Nursing provide expertise that enhances the contribution of these disciplines to CALGB studies. Scientific resources committees, including Clinical Research Associates, Pathology and Radiation Oncology, provide essential quality assurance and training activities for the Group. Major areas of emphasis in CALGB include development of innovative treatments for patients with cancer; studies of molecular predictors of prognosis and response to therapy; studies of the pharmacokinetics, pharmacodynamics and pharmacogenetics of new and established anticancer drugs; evaluation of minimally invasive surgical techniques and novel imaging technologies; determining the cost and cost-effectiveness of new cancer therapies; evaluating the impact of cancer and its treatment on the quality of life of cancer patients and their caregivers; developing new strategies for cancer prevention; and addressing the needs of special populations, particularly minorities and the elderly. A new core facility in cancer imaging was established to provide central review and archiving of PET and CT images and to set standards for image acquisition and transmission at CALGB institutions. Three new molecular reference laboratories are proposed in this application to provide biomarker assessments that are necessary to determine patient eligibility or treatment assignment in CALGB studies of targeted therapies. Three established biorepositories collect, archive and distribute frozen and paraffin-embedded solid tumor tissues, leukemia cells, plasma, serum, urine and DNA for correlative science studies.
描述(由申请人提供):CALGB 由 26 个学术医疗中心和 200 多家附属社区医院组成,致力于通过开展对照临床试验来改善癌症治疗并更好地了解肿瘤生物学和癌症治疗结果。该小组有超过 4,000 名成员,包括肿瘤科医生、放射科医生、病理学家、统计学家、临床研究员、肿瘤护士、药剂师、健康结果研究人员和基础科学家参与这些研究。 25-30 个 III 期方案随时处于活动状态,同时还有 II 期和 I 期研究,为大规模随机试验的适当设计提供所需的初步数据。该集团的多学科疾病委员会设计并实施治疗白血病、淋巴瘤、乳腺癌、呼吸道癌、GI和GU癌症患者的方案。模态委员会,包括白血病相关科学、影像、药理学和实验治疗、外科、移植、老年人癌症、癌症控制和健康结果以及肿瘤护理,提供专业知识,增强这些学科对 CALGB 研究的贡献。科学资源委员会,包括临床研究助理、病理学和放射肿瘤学,为集团提供必要的质量保证和培训活动。 CALGB 的主要重点领域包括为癌症患者开发创新疗法;预后和治疗反应的分子预测因子的研究;新药和现有抗癌药物的药代动力学、药效学和药物遗传学研究;微创手术技术和新型成像技术的评估;确定新癌症疗法的成本和成本效益;评估癌症及其治疗对癌症患者及其护理人员生活质量的影响;制定癌症预防新策略;满足特殊人群的需求,特别是少数民族和老年人的需求。建立了一个新的癌症成像核心设施,以提供 PET 和 CT 图像的集中审查和存档,并为 CALGB 机构的图像采集和传输制定标准。本申请提出了三个新的分子参考实验室,以提供确定患者资格或靶向治疗 CALGB 研究中的治疗分配所必需的生物标志物评估。三个已建立的生物样本库收集、存档和分发冷冻和石蜡包埋的实体瘤组织、白血病细胞、血浆、血清、尿液和 DNA,用于相关科学研究。

项目成果

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RICHARD L SCHILSKY其他文献

RICHARD L SCHILSKY的其他文献

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{{ truncateString('RICHARD L SCHILSKY', 18)}}的其他基金

Cancer and Leukemia Group B Human Specimen Repositories
癌症和白血病 B 组人类样本库
  • 批准号:
    7074058
  • 财政年份:
    2005
  • 资助金额:
    $ 20.14万
  • 项目类别:
Cancer and Leukemia Group B Human Specimen Repositories
癌症和白血病 B 组人类样本库
  • 批准号:
    7218023
  • 财政年份:
    2005
  • 资助金额:
    $ 20.14万
  • 项目类别:
Cancer and Leukemia Group B Human Specimen Repositories
癌症和白血病 B 组人类样本库
  • 批准号:
    6930205
  • 财政年份:
    2005
  • 资助金额:
    $ 20.14万
  • 项目类别:
Cancer and Leukemia Group B Human Specimen Repositories
癌症和白血病 B 组人类样本库
  • 批准号:
    7394411
  • 财政年份:
    2005
  • 资助金额:
    $ 20.14万
  • 项目类别:
Cancer and Leukemia Group B Human Specimen Repositories
癌症和白血病 B 组人类样本库
  • 批准号:
    7596998
  • 财政年份:
    2005
  • 资助金额:
    $ 20.14万
  • 项目类别:
CORE--DEVELOPMENTAL FUNDS
核心——发展基金
  • 批准号:
    6397819
  • 财政年份:
    2000
  • 资助金额:
    $ 20.14万
  • 项目类别:
CALGB STUDIES OF BREAST CANCER IN THE ELDERLY
CALGB 对老年人乳腺癌的研究
  • 批准号:
    6649265
  • 财政年份:
    2000
  • 资助金额:
    $ 20.14万
  • 项目类别:
CALGB STUDIES OF BREAST CANCER IN THE ELDERLY
CALGB 对老年人乳腺癌的研究
  • 批准号:
    6792574
  • 财政年份:
    2000
  • 资助金额:
    $ 20.14万
  • 项目类别:
CALGB STUDIES OF BREAST CANCER IN THE ELDERLY
CALGB 对老年人乳腺癌的研究
  • 批准号:
    6377817
  • 财政年份:
    2000
  • 资助金额:
    $ 20.14万
  • 项目类别:
CALGB STUDIES OF BREAST CANCER IN THE ELDERLY
CALGB 对老年人乳腺癌的研究
  • 批准号:
    6292671
  • 财政年份:
    2000
  • 资助金额:
    $ 20.14万
  • 项目类别:

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  • 批准号:
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