Cervical T Cell Immunity to C. trachomatis
宫颈 T 细胞对沙眼衣原体的免疫
基本信息
- 批准号:7979772
- 负责人:
- 金额:$ 14.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ModelAntibiotic TherapyAntigen PresentationAntigen Presentation PathwayAntigen-Presenting CellsAntigensAreaBacterial InfectionsBlood CirculationCD3 AntigensCD8B1 geneCell secretionCellsCervicalCervix UteriCharacteristicsChlamydiaChlamydia trachomatisChronicChronic DiseaseClone CellsContractsCross PresentationCytoplasmic GranulesDataDevelopmentDiagnosticDiseaseEndocervical MucosaEndocervixEpithelialEpithelial CellsEpitheliumEventFoundationsFrequenciesHIV InfectionsHIV-1Health Care CostsHistocompatibility Antigens Class IIHomingHost resistanceHumanImmuneImmune responseImmune systemImmunityImmunologyInfectionInfection ControlKnowledgeLaboratoriesLocal MicrobicidesLouisianaLymphocyte FunctionLymphoidLyticMaintenanceMediatingMethodologyModelingMolecular ProfilingMusOrganismOutcomePathway interactionsPatternPhasePhenotypePlayPopulationPredispositionProcessProductionResearchResearch DesignResearch InfrastructureResourcesRoleSamplingSiteSourceSpecimenStructure of thyroid parafollicular cellT-LymphocyteTestingTime StudyTissuesVaccinesVacuoleWomancohortcytokinedesignhuman diseasein vivokillingsmucosal sitepathogenpatient populationperipheral bloodreproductiveresponsetraffickingvaccination strategy
项目摘要
Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. Devastating reproductive
consequences of chronic C. trachomatis disease and a predisposition to HIV infection make progress towards the
development of effective vaccination strategies imperative. However, limited information in several key areas has
severely hampered progress in this area. Animal models have shown that T cell responses are central to host
resistance but do not reproduce all the critical features of human disease. C. trachomatis is an obligate
intracellular pathogen that primarily infects columnar epithelial cells of the endocervix in women, yet little is
known either of the inductive or effector phases of local immunity in these tissues. Immune cells at mucosal sites
are phenotypically and functionally distinct from their counterparts in the circulation and it is increasingly clear
that the local milieu plays an important role in regulating local immunity. Nevertheless, almost all human studies
to date have focused, perhaps inappropriately, on C. trachomatis-specific immunity in the circulation, since great
difficulties have, to date, attended isolation of endocervical lymphoid ceils. Here, each of these issues will be
addressed. The primary focus of this application is to characterize T cell immune responses at the primary site of
C. trachomatis infection in the human endocervix with the underlying hypothesis that activity of these subpopulations,
rather than circulating T cells, most accurately reflects the critical host response against this
pathogen. Initially, the local immune milieu will be characterized using secretions and cytobrush cell specimens
from C. trachomatis-infected women both pre-and post-antibiotic treatment and from uninfected controls.
Comparisons with circulating T cell populations will clarify unique features of the mucosal T cell repertoire.
Next, the frequencies, cytokine expression profiles and lytic activities of endocervical and circulating C.
trachomatis-specific CD4 and CD8 T cells both will be more closely defined both directly ex vivo and in cloned
cell populations. Finally, in studies with our T cell clones, processing and presentation of C. trachomatis antigens
will be characterized, using immortalized endocervical columnar epithelial cells that are genetically or
biochemically manipulated for directed inhibition of specific intraceUular trafficking pathways. This study design
will clarify interactions between C. trachomatis and the cervical immune system that will ultimately aid greatly in
delineating protective immune responses against C. trachomatis and the development of effective vaccines.
沙眼衣原体是最普遍的性传播细菌感染。毁灭性的生殖
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ALISON J. QUAYLE其他文献
ALISON J. QUAYLE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ALISON J. QUAYLE', 18)}}的其他基金
Prevention of HIV transmission/acquisition through informed contraceptive choice
通过知情避孕选择预防艾滋病毒传播/获得
- 批准号:
8588629 - 财政年份:2013
- 资助金额:
$ 14.3万 - 项目类别:
Prevention of HIV transmission/acquisition through informed contraceptive choice
通过知情避孕选择预防艾滋病毒传播/获得
- 批准号:
9089848 - 财政年份:2013
- 资助金额:
$ 14.3万 - 项目类别:
Prevention of HIV transmission/acquisition through informed contraceptive choice
通过知情避孕选择预防艾滋病毒传播/获得
- 批准号:
8862383 - 财政年份:2013
- 资助金额:
$ 14.3万 - 项目类别:
Prevention of HIV transmission/acquisition through informed contraceptive choice
通过知情避孕选择预防艾滋病毒传播/获得
- 批准号:
8706037 - 财政年份:2013
- 资助金额:
$ 14.3万 - 项目类别:
Cervical T cell immunity to Chlamydia trachomatis
宫颈T细胞对沙眼衣原体的免疫
- 批准号:
7508879 - 财政年份:2007
- 资助金额:
$ 14.3万 - 项目类别:
HUMAN DEFENSIN-5 IN FEMALE GENITAL TRACT IMMUNE DEFENSE
女性生殖道免疫防御中的 HUMAN DEFENSIN-5
- 批准号:
6373592 - 财政年份:1999
- 资助金额:
$ 14.3万 - 项目类别:
HUMAN DEFENSIN-5 IN FEMALE GENITAL TRACT IMMUNE DEFENSE
女性生殖道免疫防御中的 HUMAN DEFENSIN-5
- 批准号:
6170185 - 财政年份:1999
- 资助金额:
$ 14.3万 - 项目类别:
HUMAN DEFENSIN-5 IN FEMALE GENITAL TRACT IMMUNE DEFENSE
女性生殖道免疫防御中的 HUMAN DEFENSIN-5
- 批准号:
2758873 - 财政年份:1999
- 资助金额:
$ 14.3万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 14.3万 - 项目类别:
Grant-in-Aid for Early-Career Scientists














{{item.name}}会员




