IMAGING CORE

简历指出，评论者对“创新和最先进的” 成像核心，但也指出了一些弱点，主要是缺乏一个时间表，建设 2-光子显微镜和关注的能力，雇用和培训所需的高层次专家， 工作人员的设施。个别审查中的关切涉及核心管理的细节。中的每 这些问题在订正计划中得到处理： 首先，我们提供了一个详细的时间表，为建设的双光子显微镜，这将需要 大约四个月。时间表是根据最近建造相同设施的经验制定的。 其次，我们招募了高水平的影像学专家。石楠·J·罗斯博士拥有博士学位。在 听觉细胞神经生理学，目前是伊恩帕克博士的博士后研究员， 使用双光子显微镜观察Ca2+瞬变。她对双光子有相当丰富的经验 成像，包括构建仪器和进行实验，在体内和体外。她是 非常有资格，并对这个专业机会充满热情。 最后，提供了有关核心管理的其他详细信息。特别是，我们将建立 一个咨询委员会，以协助核心主任，卡丽娜克莱默博士，在设置和评估 核心资源使用的优先次序。P30董事和执行委员会将提供指导 确定优先事项和评估资源使用情况。咨询委员会将每季度举行会议， 将由永久成员帕克博士、罗斯博士和一名额外成员组成 从核心用户中选出。最后，我们提供了缺乏类似的信息， UCI校园内的设施。

The resume notes that the reviewers were enthusiastic about the "innovative and state-of-the-art" Imaging Core, but also indicates some weaknesses, primarily the lack of a timetable for building the 2-photon microscope and concern over the ability to hire and train the high-level specialist needed to staff the facility. Concerns in individual reviews relate to the details of Core administration. Each of these issues is addressed in the revised plan: First, we provide a detailed timetable for the construction of the 2-photon microscope, which will take about four months. The timetable is based on recent experience constructing identical facilities. Second, we have recruited the high-level Imaging Specialist. Dr. Heather J. Rose has a Ph.D. in auditory cellular neurophysiology and currently is a postdoctoral fellow with Dr. Ian Parker studying Ca2+ transients using a 2-photon microscope. She has considerable experience with 2-photon imaging, including building instruments and conducting experiments, in vivo and in vitro. She is eminently qualified and is enthusiastic about this professional opportunity. Finally, additional details regarding Core administration are provided. In particular, we will establish an Advisory Committee to assist the Core director, Dr. Karina Cramer, in setting and evaluating priorities for use of Core resources. The P30 Director and Executive Committee will provide direction for setting priorities and evaluating use of resources. The Advisory Committee will meet quarterly and will consist of Dr. Parker as a permanent member, Dr. Rose, and an additional member to be selected from among Core users. Finally, we have provided information on the lack of similar facilities on the UCI campus.