Recruitment and Retention Best practices in Primary Care Settings

描述（由申请人提供）：本申请涉及广泛的挑战领域（02）：生物伦理学和具体挑战主题02-OD（OSP）-102“健康差异和参与研究的伦理问题”，其中指出，需要进行研究，以评估少数群体和服务不足的人口在研究中的代表性不足，查明参与研究的障碍，并制定克服这些障碍的办法。基于初级保健实践的研究网络（PBRN）经常报告其研究的高参与率。NIH将PBRN视为转化研究项目的重要工具，并通过临床和转化科学奖给予大力支持。初级保健最重要的特点之一是医生/病人关系的连续性和信任。然而，很少有人知道PBRN如何成功招募和保留，特别是少数民族和多样化的患者。拟议研究的目标是开发基础设施，以支持PBRN参与任何设计的临床研究。其目的是确定招募和保留不同的初级保健患者进入临床研究的最佳实践。这将通过一项合作性多地点研究来完成，该研究涉及5个地理上分散的生产性PBRN初级保健多种族网络（PRIME Net）联盟成员，这些成员有一个共同的目的，即重点研究传统上代表性不足且往往服务不足的人口群体。每个参与的PRIME Net成员都有针对特定种族群体开展临床研究的经验;将代表以下不同人群：非洲裔美国人、西班牙裔美国人、华裔美国人、阿拉伯裔美国人和纳瓦霍族。这些不同的患者群体将为道德招募和保留策略提供见解。该研究产品将是招募和保留最佳实践指南，用于将不同患者纳入具有不同设计复杂性等级的研究。研究目标将通过以下3个具体目标实现：目标1：确定招募和留住不同参与者参与需要不同承诺和参与程度的各种临床研究设计的策略。目标2：获得不同的初级保健患者对招募/保留最佳实践的看法。目标3：与更广泛的PBRN研究界确认最佳做法。目标4：汇编和传播《征聘和留用最佳做法指南》。本研究具有创新性，通过混合方法开发了一种最佳实践模型，该模型综合了患者研究相关问题，这些问题来自：a）不同的初级保健患者; B）关于招募和保留不同患者进入研究的现有信息;以及c）有成功招募患者进入初级保健研究历史的经验丰富的PBRN研究人员。本研究将开发基础设施，以支持基于初级保健实践的研究网络（PBRN）参与任何设计的临床研究。其目的是确定招募和保留不同的初级保健患者进入临床研究的最佳实践。这将通过一项合作性多中心研究来完成，该研究涉及PBRN的初级保健多种族网络（PRIME Net）联盟的5个地理上分散的成员。一个有形的产品将是招聘和保留最佳做法指南。本研究具有创新性，通过混合方法开发了一种最佳实践模型，该模型综合了患者研究相关问题，这些问题来自：a）不同的初级保健患者; B）关于招募和保留不同患者进入研究的现有信息;以及c）有成功招募患者进入初级保健研究历史的经验丰富的PBRN研究人员。

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (02): Bioethics and specific challenge topic 02-OD (OSP)-102 "Ethical Issues in Health Disparities and Access to Participation in Research," which states that studies are needed to assess the under-representation of minority and underserved populations in research, to identify barriers to participation in research and to develop approaches for overcoming them. Primary care practice-based research networks (PBRNs) often report high participation rates in their studies. The NIH recognizes PBRNs as important vehicles for translational research projects, strongly supporting them through Clinical and Translational Science Awards. One of the most important features of primary care is the continuity and trust in the physician/patient relationship. However, little is known about how PBRNs achieve success in recruitment and retention, particularly with minority and diverse patients. The goal of the proposed study is to develop infrastructure to support PBRNs to participate in clinical research studies of any design. The objective is to identify best practices for recruiting and retaining diverse primary care patients into clinical research studies. This will be accomplished with a collaborative multi-site study that engages 5 geographically dispersed members of the Primary Care Multiethnic Network (PRIME Net) consortium of productive PBRNs that share a common purpose of conducting research focused on traditionally underrepresented and often underserved population groups. Each participating PRIME Net member is experienced in conducting clinical research with a particular ethnic group; the following diverse populations will be represented: African American, Hispanic American, Chinese American, Arab American and the Navajo nation. These diverse patient groups will provide insight for strategies for ethical recruiting and retention. The study product will be the Guide to Recruiting and Retention Best Practices for accruing diverse patients into studies with varying gradations of design complexity. The study objective will be met by the following 3 Specific Aims: Aim 1: Identify strategies to recruit and retain diverse participants into various clinical study designs that require gradations of commitment and participation. Aim 2: Obtain perspectives of diverse primary care patients on recruiting/retention best practices. Aim 3: Confirm best practices with the broader PBRN research community. Aim 4: Compile and disseminate the Guide to Recruiting and Retention Best Practices. This study is innovative through its mixed-methods approach to developing a best practice model that synthesizes patient research-related concerns as obtained from: a) diverse primary care patients; b) existing information on recruitment and retention of diverse patients into research studies; and c) experienced PBRN researchers with a history of success in enrolling patients into primary care studies. Recruitment and Retention Best Practices in Primary Care Settings Brief Narrative This study will develop infrastructure to support primary care practice-based research networks (PBRNs) to participate in clinical research studies of any design. The objective is to identify best practices for recruiting and retaining diverse primary care patients into clinical research studies. This will be accomplished with a collaborative multi-site study that engages 5 geographically dispersed members of the Primary Care Multiethnic Network (PRIME Net) consortium of PBRNs. A tangible produce will be a Guide to Recruiting and Retention Best Practices. This study is innovative through its mixed-methods approach to developing a best practice model that synthesizes patient research-related concerns as obtained from: a) diverse primary care patients; b) existing information on recruitment and retention of diverse patients into research studies; and c) experienced PBRN researchers with a history of success in enrolling patients into primary care studies.