Development of a Cognitive Paradigm Ontology: BrainMap and BIRN Intergration

认知范式本体的开发：BrainMap 和 BIRN 集成

• 批准号: 7900443
• 负责人: Angela R Laird
• 金额: $ 27.41万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900443
• 关键词: Adopted; Adoption; Advisory Committees; Anatomy; Archives; Back; Biomedical Informatics Research Network; Characteristics; Classification; Code; Cognitive; Cognitive Science; Collaborations; Communication; Communities; Conflict (Psychology); Consult; Controlled Vocabulary; Data; Data Set; Data Sources; Data Storage and Retrieval; Databases; Development; Educational workshop; Electroencephalography; Electromagnetics; Feedback; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Genes; Goals; Human; Image; Informatics; Instruction; Label; Letters; Link; Literature; Maps; Measures; Medical; Medical Imaging; Memory; Meta-Analysis; Methods; Mining; Mission; Modality; Modeling; Names; Neurosciences; Ontology; PTPNS1 gene; Performance; Procedures; PubMed; Publications; Research; Resolution; Resources; Response to stimulus physiology; Sampling; Scheme; Series; Societies; Stimulus; Strigiformes; Structure; Systematized Nomenclature of Medicine; Techniques; Technology; Terminology; Testing; Work; abstracting; base; biomedical ontology; clinical care; community planning; data sharing; design; efficacy testing; image archival system; information framework; interest; interoperability; member; neuroimaging; neuroinformatics; novel; public health relevance; relating to nervous system; response; time use; tool; wiki

DESCRIPTION (provided by applicant): The objective of this proposal is to develop, evaluate, and distribute a domain ontology of cognitive paradigms for application and use in the functional neuroimaging community. This cognitive paradigm ontology, CogPO, will be developed through the integration of two well known and established databases, the Functional Imaging Biomedical Informatics Research Network (FBIRN) Human Imaging Database (HID) and the BrainMap database. The design of CogPO concentrates on what can be observed directly: categorization of each paradigm in terms of (1) the stimulus presented to the subjects, (2) the requested instructions, and (3) the returned response. All paradigms are essentially comprised of these three orthogonal components, and formalizing an ontology around them is a clear and direct approach to describing paradigms. This structured, well-defined, common and controlled vocabulary will be capable of representing the cognitive paradigms in the FBIRN Data Repository, which stores structural and functional imaging datasets for later analysis, and in BrainMap, which stores analyzed results from the functional imaging literature. This proposal has been designed to include strong collaboration with the National Center for Biomedical Ontology (NCBO) and the Neuroinformatics Information Framework (NIF). Neither the NCBO nor the NIF currently seeks to develop an ontology of cognitive paradigms; thus, the current proposal is novel and does not conflict with any existing ontology efforts, but is a complementary endeavor. Through a series of workshops, CogPO developers will consult both the domain experts (the neuroimaging research community) and the ontological experts (NCBO) and the BIRN Ontology Task Force (OTF). CogPO developers also plan to allow user input and feedback from the entire neuroimaging community through the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC). This proposal includes a formal plan for community acceptance of the developed ontology, complete with a list of concrete deliverables in Protigi-OWL format to be distributed by the end of the funding period, which can be utilized not only by FBIRN and BrainMap users, but also by the entire neuroimaging community. It is our ultimate aim that CogPO be designed to enable its extension to a broader context in cognitive sciences. PUBLIC HEALTH RELEVANCE: CogPO, a domain ontology of cognitive paradigms, would facilitate descriptions of cognitive experimental paradigms in ways that are machine-readable and machine-interpretable, to allow communication and automated data sharing across diverse databases and data sources. This ontology will be made available for adoption not only by other fMRI databases, but also for archives of other neuroimaging modalities (e.g., EEG or MEG data), such as the Neural ElectroMagnetic Ontologies (NEMO), and literature neuroinformatics efforts such as the Society for Neuroscience's PubMed Plus. It is our ultimate aim that CogPO be designed to enable its extension to a broader context in cognitive sciences.

描述（由申请人提供）：该提案的目的是开发、评估和分发认知范式的领域本体，以供功能性神经影像学界的应用和使用。这种认知范式本体 CogPO 将通过整合两个众所周知的成熟数据库来开发，即功能成像生物医学信息学研究网络 (FBIRN) 人类成像数据库 (HID) 和 BrainMap 数据库。 CogPO 的设计集中于可以直接观察到的内容：根据 (1) 向受试者提供的刺激、(2) 请求的指令和 (3) 返回的响应对每个范式进行分类。所有范式本质上都是由这三个正交组件组成，围绕它们形式化本体是描述范式的清晰而直接的方法。这种结构化的、定义明确的、通用的和受控的词汇将能够代表 FBIRN 数据存储库和 BrainMap 中的认知范式，FBIRN 数据存储库存储结构和功能成像数据集以供以后分析，而 BrainMap 存储功能成像文献的分析结果。该提案旨在包括与国家生物医学本体中心 (NCBO) 和神经信息学信息框架 (NIF) 的强有力合作。 NCBO 和 NIF 目前都没有寻求开发认知范式的本体论；因此，当前的提议是新颖的，并不与任何现有的本体论努力相冲突，而是一种补充努力。通过一系列研讨会，CogPO 开发人员将咨询领域专家（神经影像研究社区）、本体专家 (NCBO) 和 BIRN 本体任务组 (OTF)。 CogPO 开发人员还计划通过神经影像信息学工具和资源交换所 (NITRC) 允许整个神经影像社区的用户输入和反馈。该提案包括社区接受所开发本体的正式计划，以及将在资助期结束前分发的 Protigi-OWL 格式的具体可交付成果列表，该列表不仅可供 FBIRN 和 BrainMap 用户使用，也可供整个神经影像学社区使用。我们的最终目标是 CogPO 的设计使其能够扩展到认知科学领域更广泛的领域。公共卫生相关性：CogPO 是认知范式的领域本体，它将促进以机器可读和机器可解释的方式描述认知实验范式，以允许跨不同数据库和数据源进行通信和自动数据共享。该本体不仅可供其他 fMRI 数据库采用，还可用于其他神经影像模式（例如 EEG 或 MEG 数据）的档案，例如神经电磁本体 (NEMO)，以及文献神经信息学工作，例如神经科学协会的 PubMed Plus。我们的最终目标是 CogPO 的设计使其能够扩展到认知科学领域更广泛的领域。