Loyola Research Computing Core

描述（由申请人提供）：洛约拉大学医学中心（LUMC）的多学科生物医学研究项目，包括医学院和护理学院以及邻近的爱德华·j·海恩斯小VA医院的教师，由一个团队和转化方法驱动-基础，临床医生和人口科学家相互作用，以确保从研究平台，患者护理和人口研究中获得的知识在各个层面上共享，以提供快速的诊断进展。治疗和预防。目前，LUMC正朝着最近完成的战略计划所确立的目标努力，目标是在5年内将研究生产力提高一倍，在10年内将研究生产力提高两倍。这些目标需要在医学信息学和生物信息学方面进行大量投资。目前，LUMC的信息技术基础设施只能满足教育和行政方面的需求，无法满足现有教师快速增长的研究需求，更不用说为满足我们的目标研究增长而增加的60名新员工了。本申请要求拨款327万元，以支持设计、建造及购买固定设备，以建立一个新的电脑设施，专门用于研究需要，以扩大我们的资讯科技能力。拟议的翻新工程将创造一个840平方英尺的空间。在斯特里奇医学院（SSOM）目前可用的空间中，包括一英尺的研究计算核心，包括轻微的结构修改和购买和安装：1)双层活动地板，2)冷却器，3)室内Liebert单元，4)模块化不间断电源系统，5)应急发电机，6)应急灭火系统，7)物理访问控制，8)21个42U计算机机架，双配电单元（pdu），9)四个固定的数据通信交换机，10)将新设施与机构的核心数据通信网络连接起来所需的光纤电缆和连接器。这一翻新将支持39名在职主要研究人员的外部资助研究，他们依靠充足的计算机资源和基础设施。这些调查人员将2010财年840万美元的积极外部资金与未来12个月710万美元的年度申请相结合。此外，翻修对正在进行的和将来的招聘至关重要。通过显著增加存储和计算能力，核心设施将支持现有教师的研究，包括：临床研究需要我们的电子病历（EMR）和其他大型数据库（如从大规模基因表达、蛋白质和代谢分析中获得的数据库）之间的交互；基因/流行病学研究需要分析，如序列数据处理和序列数据的基因型推算；研究利用高通量成像技术，产生大量的图像数据集；创造存储和在线分析处理需求的生物信息学方法；卫生服务研究利用大型国家级数据库，需要扩展的计算机基础设施来创建分析文件，进行统计分析，并维护长期档案。关于时间表，预计翻修的最终合同文件将于2011年1月1日提交，整个翻修将于2012年4月1日完成。拥有12年历史的SSOM大楼将容纳该设施，该设施归芝加哥洛约拉大学所有，翻新后的设施将在至少25年内仍然是校园研究企业的重要组成部分。洛约拉承诺提供所有额外和经常性费用。

DESCRIPTION (provided by applicant): The multidisciplinary biomedical research program at Loyola University Medical Center (LUMC), which includes the schools of medicine and nursing as well as faculty at the adjacent Edward J. Hines, Jr. VA Hospital, are driven by a team and translational approach - basic, clinician and population scientists interacting to insure that knowledge gained from the research bench, patient care and population studies is shared at all levels to provide rapid advances in diagnosis, treatment and prevention. Currently, LUMC is working toward the goals established by a recently completed Strategic Plan that targets a doubling of research productivity in 5 years and a tripling in 10 years. These goals will require a significant investment in medical informatics and bioinformatics. Presently, the information technology (IT) infrastructure available for research at LUMC also serves educational and administrative needs, and is incapable of meeting the rapidly increasing research requirements of our current faculty, not to mention the 60 addition recruitments that are necessary to meet our targeted research growth. This application requests $3.27 M to support the design, construction and fixed equipment purchases required to expand our IT capacity by establishing a new computer facility that will be designated solely for research needs. The proposed renovations, which would create an 840 sq. ft. research computing core in space currently available in the Stritch School of Medicine (SSOM), include minor structural modifications and purchase and installation of 1) a dual-tier raised floor, 2) chillers, 3) in-room Liebert units, 4) a modular uninterruptible power supply system, 5) an emergency power generator, 6) an emergency fire suppression system, 7) physical access controls, 8) twenty-one 42U computer racks with dual power distribution units (PDUs), 9) four fixed data communication switches, and 10) the fiber optic cabling and connectors required to link the new facility to the institution's core data communications network. This renovation will support the extramurally funded research of 39 active principal investigators who depend on adequate computer resources and infrastructure. These investigators have combined active extramural funding of $8.4M for FY10 with an annual request of $7.1M pending during the next 12 months. In addition, the renovation is essential for ongoing and future recruitments. By significantly increasing storage and computational capacity, the core facility will support current faculty whose research includes: clinical studies requiring interactions between our electronic medical record (EMR) and other large databases such as those obtained from large-scale gene expression, protein, and metabolic profiling; genetic/ epidemiological studies that require analyses such as sequence data processing and genotype imputations from sequence data; research utilizing high-throughput imaging technologies that generate large image data sets; bioinformatics approaches that create needs for storage and on-line analytical processing; and health services research that utilizes large national level databases and requires the expanded computer infrastructure to create analysis files, perform statistical analyses, and maintain long-term archives. With respect to timeline, it is anticipated that the final contract document for the renovation will be submitted by January 1, 2011, with the entire renovation being completed by April 1, 2012. The 12 year-old SSOM Building, which will house the facility, is owned by Loyola University Chicago, and the renovated facility will remain a vital part of the research enterprise on campus for at least 25 years. Loyola is committed to providing all additional and recurring costs.