Loyola Research Computing Core

洛约拉研究计算核心

• 批准号: 7935990
• 负责人: Richard H Kennedy
• 金额: $ 270.16万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-18 至 2013-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935990
• 关键词: 12 year old; Academic Medical Centers; Archives; Bioinformatics; Biomedical Research; Chicago; Clinical Research; Commit; Communication; Computerized Medical Record; Computers; Contracts; Core Facility; Data; Data Set; Databases; Diagnosis; Emergency Situation; Epidemiologic Studies; Equipment; Extramural Activities; Faculty; Fiber Optics; Fire - disasters; Floor; Funding; Future; Gene Expression; Genotype; Goals; Growth; Health Services Research; Hospitals; Housing; Image; Imaging technology; Information Technology; Institution; Investments; Knowledge; Link; Medical Informatics; Metabolic; Minor; Modification; Nurses; Patient Care; Population; Population Study; Power Sources; Prevention; Principal Investigator; Process; Productivity; Proteins; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Strategic Planning; System; Targeted Research; TimeLine; Universities; Work; computer infrastructure; computerized data processing; cost; design and construction; genetic profiling; medical schools; meetings; multidisciplinary; programs; square foot; translational approach

DESCRIPTION (provided by applicant): The multidisciplinary biomedical research program at Loyola University Medical Center (LUMC), which includes the schools of medicine and nursing as well as faculty at the adjacent Edward J. Hines, Jr. VA Hospital, are driven by a team and translational approach - basic, clinician and population scientists interacting to insure that knowledge gained from the research bench, patient care and population studies is shared at all levels to provide rapid advances in diagnosis, treatment and prevention. Currently, LUMC is working toward the goals established by a recently completed Strategic Plan that targets a doubling of research productivity in 5 years and a tripling in 10 years. These goals will require a significant investment in medical informatics and bioinformatics. Presently, the information technology (IT) infrastructure available for research at LUMC also serves educational and administrative needs, and is incapable of meeting the rapidly increasing research requirements of our current faculty, not to mention the 60 addition recruitments that are necessary to meet our targeted research growth. This application requests $3.27 M to support the design, construction and fixed equipment purchases required to expand our IT capacity by establishing a new computer facility that will be designated solely for research needs. The proposed renovations, which would create an 840 sq. ft. research computing core in space currently available in the Stritch School of Medicine (SSOM), include minor structural modifications and purchase and installation of 1) a dual-tier raised floor, 2) chillers, 3) in-room Liebert units, 4) a modular uninterruptible power supply system, 5) an emergency power generator, 6) an emergency fire suppression system, 7) physical access controls, 8) twenty-one 42U computer racks with dual power distribution units (PDUs), 9) four fixed data communication switches, and 10) the fiber optic cabling and connectors required to link the new facility to the institution's core data communications network. This renovation will support the extramurally funded research of 39 active principal investigators who depend on adequate computer resources and infrastructure. These investigators have combined active extramural funding of $8.4M for FY10 with an annual request of $7.1M pending during the next 12 months. In addition, the renovation is essential for ongoing and future recruitments. By significantly increasing storage and computational capacity, the core facility will support current faculty whose research includes: clinical studies requiring interactions between our electronic medical record (EMR) and other large databases such as those obtained from large-scale gene expression, protein, and metabolic profiling; genetic/ epidemiological studies that require analyses such as sequence data processing and genotype imputations from sequence data; research utilizing high-throughput imaging technologies that generate large image data sets; bioinformatics approaches that create needs for storage and on-line analytical processing; and health services research that utilizes large national level databases and requires the expanded computer infrastructure to create analysis files, perform statistical analyses, and maintain long-term archives. With respect to timeline, it is anticipated that the final contract document for the renovation will be submitted by January 1, 2011, with the entire renovation being completed by April 1, 2012. The 12 year-old SSOM Building, which will house the facility, is owned by Loyola University Chicago, and the renovated facility will remain a vital part of the research enterprise on campus for at least 25 years. Loyola is committed to providing all additional and recurring costs.

描述（由申请人提供）：洛约拉大学医学中心（LUMC）的多学科生物医学研究计划，其中包括医学和护理学院以及邻近的Edward J. Hines，Jr.的教师。VA医院由团队和转化方法驱动-基础，临床医生和人口科学家互动，以确保从研究工作台，患者护理和人口研究中获得的知识在各级共享，以提供快速的诊断，治疗和预防进展。目前，LUMC正在努力实现最近完成的战略计划所确立的目标，该计划的目标是在5年内将研究生产力翻一番，在10年内翻三倍。这些目标将需要在医学信息学和生物信息学方面进行大量投资。目前，信息技术（IT）基础设施可用于研究在LUMC也服务于教育和行政需求，是无法满足我们目前的教师迅速增长的研究需求，更不用说60个额外的招聘是必要的，以满足我们的目标研究增长。这项申请要求327万美元，以支持所需的设计，建设和固定设备的购买，以扩大我们的信息技术能力，建立一个新的计算机设施，将专门用于研究的需要。拟议的翻修，这将创造一个840平方米。英尺斯特里奇医学院（SSOM）目前可用的空间研究计算核心，包括微小的结构修改以及购买和安装1）双层活动地板，2）制冷机，3）室内Liebert单元，4）模块化不间断电源系统，5）应急发电机，6）应急灭火系统，7）物理访问控制，8）21个42 U计算机机架，带有双配电单元（PDU），9）4个固定数据通信交换机，以及10）将新设施连接到机构核心数据通信网络所需的光纤电缆和连接器。这次翻修将支持39名在职主要调查员的研究工作，这些调查员依靠的是足够的计算机资源和基础设施。这些调查人员已经将FY 10的840万美元的积极外部资金与未来12个月内每年710万美元的申请相结合。此外，翻修对目前和今后的征聘工作至关重要。通过显着增加存储和计算能力，核心设施将支持当前的教师，其研究包括：临床研究需要我们的电子病历（EMR）和其他大型数据库之间的相互作用，如从大规模基因表达，蛋白质和代谢谱;遗传/流行病学研究，需要分析，如序列数据处理和基因型插补序列数据;利用高通量成像技术生成大型图像数据集的研究;需要存储和在线分析处理的生物信息学方法;以及利用大型国家级数据库并需要扩展计算机基础设施以创建分析文件、进行统计分析和维护长期档案的卫生服务研究。关于时间轴，预计翻修的最后合同文件将于2011年1月1日提交，整个翻修将于2012年4月1日完成。这座有12年历史的SSOM大楼将容纳该设施，由洛约拉大学芝加哥拥有，翻新后的设施将在至少25年内仍然是校园研究企业的重要组成部分。洛约拉致力于提供所有额外和经常性费用。

项目成果

The female urinary microbiome: a comparison of women with and without urgency urinary incontinence.

• DOI: 10.1128/mbio.01283-14
• 发表时间: 2014-07-08
• 期刊: mBio
• 影响因子: 6.4
• 作者: Pearce MM;Hilt EE;Rosenfeld AB;Zilliox MJ;Thomas-White K;Fok C;Kliethermes S;Schreckenberger PC;Brubaker L;Gai X;Wolfe AJ
• 通讯作者: Wolfe AJ

Incontinence medication response relates to the female urinary microbiota.

• DOI: 10.1007/s00192-015-2847-x
• 发表时间: 2016-05
• 期刊: INTERNATIONAL UROGYNECOLOGY JOURNAL
• 影响因子: 1.8
• 作者: Thomas-White, Krystal J.;Hilt, Evann E.;Fok, Cynthia;Pearce, Meghan M.;Mueller, Elizabeth R.;Kliethermes, Stephanie;Jacobs, Kristin;Zilliox, Michael J.;Brincat, Cynthia;Price, Travis K.;Kuffel, Gina;Schreckenberger, Paul;Gai, Xiaowu;Brubaker, Linda;Wolfe, Alan J.
• 通讯作者: Wolfe, Alan J.