Molecular and Mechanical Investigations to Define Collagen and Elastic Fiber Homeostasis in Cervical Remodeling During a Term and Preterm Pregnancy
定义足月和早产期间宫颈重塑中胶原蛋白和弹性纤维稳态的分子和力学研究
基本信息
- 批准号:10752526
- 负责人:
- 金额:$ 69.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-19 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAnimal ModelAutomobile DrivingBiologyBiomechanicsBirthBirth RateCell Culture SystemCervicalCervical RipeningCervix IncompetenceCervix UteriClinicalCollagenCollagen FiberCollagen FibrilDataDefectDegradation PathwayDiagnosisElastic FiberElastin FiberEnsureEquilibriumEstrogen TherapyEstrogensEventExtracellular MatrixFBLN5 geneFBN1FetusFibrillar CollagenFunctional disorderGeneticGenetic TranscriptionHomeostasisHumanInflammationInflammatoryInterventionInvestigationKnockout MiceKnowledgeLengthLeucineMaintenanceMeasuresMechanicsMediatingMetabolismMetalloproteasesModalityModelingMolecularMultiscale MechanicsMusMutationPathway interactionsPeptide HydrolasesPhasePhysiologicalPost-Translational Protein ProcessingPostpartum PeriodPregnancyPremature BirthPremature InfantPreventionPrevention therapyProcessProgesteronePropertyProteoglycanProteomicsRegulationRiskRisk AssessmentRoleStromal CellsStructural defectStructureStructure-Activity RelationshipTestingTissuesWomanWorkbiglycanbiomarker identificationcervical remodelingclinically relevantcrosslinkdecorindensitydisabilityextracellularinsightmechanical propertiesmortality riskmouse modelnovelposttranscriptionalpregnantprematureprogramsrepairedresiliencespatiotemporalsteroid hormonetool
项目摘要
Abstract
The remodeling of the cervix to prepare for birth begins early in pregnancy and is orchestrated by a precisely
timed change in the structure and mechanical function of the cervical extracellular matrix (ECM). Understanding
the molecular pathways that alter the ECM in pregnancy while maintaining a synthesis and degradation
equilibrium is necessary to discern cervical function and how it mechanically protects the fetus. More importantly,
it is critical to determine when and how these cervical ECM synthesis and degradation processes are perturbed,
which compromise cervical mechanical function and creates a risk for preterm birth. Our groups prior work
provides evidence 1) of rapid collagen turnover rates in both nonpregnant and pregnant cervix 2) dysfunctional
cervical extracellular matrix leads to disrupted cervical biomechanical function in novel mouse models 3) cervical
mechanical properties evolve in distinct stages in concert with shifts in ECM structure and 4) mouse models of
cervical dysfunction are a useful tool to evaluate cervical mechanics. Building on these findings, we aim to better
define molecular pathways of collagen degradation and elastic fiber elastogenesis that ensure ECM homeostasis
in physiologic remodeling. Secondly, we aim to understand the complexity of mechanical parameters derived
from collagen and elastic fibers at multiple length scales. Collectively, the proposed studies, based on compelling
preliminary data, can expand our understanding of basic mechanisms in cervical biology and mechanobiology
and expand the possibilities for clinical intervention in PTB.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MALA S. MAHENDROO其他文献
MALA S. MAHENDROO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MALA S. MAHENDROO', 18)}}的其他基金
Functional and Molecular Characterization of Epithelial Subtypes in Cervical Remodeling and Preterm Birth
宫颈重塑和早产中上皮亚型的功能和分子特征
- 批准号:
10681015 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Genomic Consequences of Estrogen Receptor Activation in the Cervix
子宫颈雌激素受体激活的基因组后果
- 批准号:
10204064 - 财政年份:2017
- 资助金额:
$ 69.93万 - 项目类别:
Mechanisms by which steroid hormones modulate cervical extracellular matrix structure and function during pregnancy and provide therapeutic protection against preterm birth
类固醇激素在怀孕期间调节宫颈细胞外基质结构和功能并提供针对早产的治疗保护的机制
- 批准号:
9754844 - 财政年份:2016
- 资助金额:
$ 69.93万 - 项目类别:
Mechanisms by which steroid hormones modulate cervical extracellular matrix structure and function during pregnancy and provide therapeutic protection against preterm birth
类固醇激素在怀孕期间调节宫颈细胞外基质结构和功能并提供针对早产的治疗保护的机制
- 批准号:
9982389 - 财政年份:2016
- 资助金额:
$ 69.93万 - 项目类别:
Mechanisms of Cervical Epithelial Barrier Protection Against Ascending Infection and Preterm Birth
宫颈上皮屏障预防上行感染和早产的机制
- 批准号:
10063455 - 财政年份:2016
- 资助金额:
$ 69.93万 - 项目类别:
Mechanisms by which steroid hormones modulate cervical extracellular matrix structure and function during pregnancy and provide therapeutic protection against preterm birth
类固醇激素在怀孕期间调节宫颈细胞外基质结构和功能并提供针对早产的治疗保护的机制
- 批准号:
9334281 - 财政年份:2016
- 资助金额:
$ 69.93万 - 项目类别:
Mechanisms of infection-mediated cervical ripening
感染介导的宫颈成熟机制
- 批准号:
9252296 - 财政年份:2016
- 资助金额:
$ 69.93万 - 项目类别:
Mechanisms by which steroid hormones modulate cervical extracellular matrix structure and function during pregnancy and provide therapeutic protection against preterm birth
类固醇激素在怀孕期间调节宫颈细胞外基质结构和功能并提供针对早产的治疗保护的机制
- 批准号:
9157750 - 财政年份:2016
- 资助金额:
$ 69.93万 - 项目类别:
REGULATION AND FUNCTION OF HYALURONAN IN CERVICAL REMODELING
透明质酸在宫颈重塑中的调节和功能
- 批准号:
7555046 - 财政年份:2007
- 资助金额:
$ 69.93万 - 项目类别:
Project 3 REGULATION AND FUNCTION OF HYALURONAN
项目3 透明质酸的调控与功能
- 批准号:
6896286 - 财政年份:2004
- 资助金额:
$ 69.93万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 69.93万 - 项目类别:
Grant-in-Aid for Early-Career Scientists