Modulating cortical inhibitory networks to improve stroke recovery

调节皮质抑制网络以改善中风恢复

基本信息

批准号：
10753362
负责人：
Sergio Estevan Arroyo
金额：
--
依托单位：
VETERANS AFFAIRS MED CTR SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10753362
关键词：
Address Admission activity Affect Animals Area Brain Calcium Cells Clinical Trials Complex Data Electronic Medical Records and Genomics Network Ensure Environment Experimental Designs Functional disorder Future Goals Hospitals Investigation Laboratories Learning Left Mentorship Modification Motor Cortex Movement Neurons Patients Pattern Physicians Population Population Dynamics Preparation Program Development Publications Randomized Reaction Time Recovery Reproducibility Research Research Personnel San Francisco Scientist Stroke System Testing Training Translating Veterans calmodulin-dependent protein kinase II career development cell cortex cell type cohort design disability excitatory neuron experience experimental study functional improvement grasp imaging system improved inhibitory neuron injury recovery insight kinematics long term recovery motor behavior motor function improvement motor learning motor recovery neural circuit neurophysiology neuroregulation novel therapeutics optogenetics post stroke programs recruit sex skills stroke patient stroke recovery stroke therapy support network tool

项目摘要

The overarching goal of this project is to identify new targets for neural circuit modulation to facilitate motor recovery after stroke. To accomplish this, I propose to identify how dynamics in a specific inhibitory cell network participates in motor learning, investigate how these dynamics are disrupted by stroke, and test whether their modulation can improve recovery. Completion of this project will provide me with opportunities to fill key gaps in my current skillset and equip me to launch an independent research program in the neurophysiology of recovery. I have carefully designed a career development program to address these training gaps through a combination of hands-on experimentation, coursework and didactics, and mentorship from an exemplary team of physician scientists at the San Francisco VA and UCSF. My mentorship team has a strong record of training and developing young investigators; together with the rich research environment at the San Francisco VA, I will be well-equipped to accomplish my outlined training goals. The results from these experiments will lead to publications and pave the way for many important lines of investigation I will pursue in my own laboratory.

该项目的总体目标是确定神经电路调制的新目标促进中风后运动恢复。为了实现这一目标，我建议确定一个动态特定的抑制性细胞网络参与运动学习，研究这些动态的方式受到中风的破坏，并测试其调节是否可以改善恢复。完成此操作项目将为我提供填补当前技能中关键空白的机会，并使我装备启动一项独立的恢复神经生理学研究计划。我仔细设计了一项职业发展计划，以解决这些培训差距动手实验，课程和教学法以及一个模范团队的指导弗吉尼亚州旧金山和UCSF的医师科学家。我的指导团队有一个很强的培训和发展年轻调查员的记录；与丰富的研究环境一起在弗吉尼亚州旧金山的弗吉尼亚州，我将有能力实现概述的培训目标。这这些实验的结果将导致出版物，并为许多重要界限铺平道路我将在自己的实验室中进行调查。