Modulating cortical inhibitory networks to improve stroke recovery

该项目的总体目标是确定神经回路调制的新目标 促进中风后的运动恢复。为了实现这一点，我建议确定一个 特定的抑制细胞网络参与运动学习，研究这些动力学是如何 并测试它们的调节是否能促进恢复。完成这项工作 项目将为我提供机会来填补我当前技能中的关键空白，并使我具备 启动康复神经生理学的独立研究计划。我小心翼翼地 设计了一项职业发展计划，通过组合 实践实验、课程作业和教学，以及来自模范团队的指导 旧金山退伍军人管理局和加州大学旧金山分校的内科科学家。我的导师团队有一个强大的 培养和发展青年调查人员的记录；以及丰富的研究环境 在旧金山退伍军人管理局，我将做好充分的准备，完成我概述的培训目标。这个 这些实验的结果将导致发表文章，并为许多重要的路线铺平道路 我会在我自己的实验室里进行调查。

The overarching goal of this project is to identify new targets for neural circuit modulation to facilitate motor recovery after stroke. To accomplish this, I propose to identify how dynamics in a specific inhibitory cell network participates in motor learning, investigate how these dynamics are disrupted by stroke, and test whether their modulation can improve recovery. Completion of this project will provide me with opportunities to fill key gaps in my current skillset and equip me to launch an independent research program in the neurophysiology of recovery. I have carefully designed a career development program to address these training gaps through a combination of hands-on experimentation, coursework and didactics, and mentorship from an exemplary team of physician scientists at the San Francisco VA and UCSF. My mentorship team has a strong record of training and developing young investigators; together with the rich research environment at the San Francisco VA, I will be well-equipped to accomplish my outlined training goals. The results from these experiments will lead to publications and pave the way for many important lines of investigation I will pursue in my own laboratory.