权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Modulating cortical inhibitory networks to improve stroke recovery

调节皮质抑制网络以改善中风恢复

基本信息

批准号：
10753362
负责人：
Sergio Estevan Arroyo
金额：
--
依托单位：
VETERANS AFFAIRS MED CTR SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10753362
关键词：
Address Admission activity Affect Animals Area Brain Calcium Cells Clinical Trials Complex Data Electronic Medical Records and Genomics Network Ensure Environment Experimental Designs Functional disorder Future Goals Hospitals Investigation Laboratories Learning Left Mentorship Modification Motor Cortex Movement Neurons Patients Pattern Physicians Population Population Dynamics Preparation Program Development Publications Randomized Reaction Time Recovery Reproducibility Research Research Personnel San Francisco Scientist Stroke System Testing Training Translating Veterans calmodulin-dependent protein kinase II career development cell cortex cell type cohort design disability excitatory neuron experience experimental study functional improvement grasp imaging system improved inhibitory neuron injury recovery insight kinematics long term recovery motor behavior motor function improvement motor learning motor recovery neural circuit neurophysiology neuroregulation novel therapeutics optogenetics post stroke programs recruit sex skills stroke patient stroke recovery stroke therapy support network tool

项目摘要

The overarching goal of this project is to identify new targets for neural circuit modulation to facilitate motor recovery after stroke. To accomplish this, I propose to identify how dynamics in a specific inhibitory cell network participates in motor learning, investigate how these dynamics are disrupted by stroke, and test whether their modulation can improve recovery. Completion of this project will provide me with opportunities to fill key gaps in my current skillset and equip me to launch an independent research program in the neurophysiology of recovery. I have carefully designed a career development program to address these training gaps through a combination of hands-on experimentation, coursework and didactics, and mentorship from an exemplary team of physician scientists at the San Francisco VA and UCSF. My mentorship team has a strong record of training and developing young investigators; together with the rich research environment at the San Francisco VA, I will be well-equipped to accomplish my outlined training goals. The results from these experiments will lead to publications and pave the way for many important lines of investigation I will pursue in my own laboratory.

该项目的首要目标是确定神经回路调制的新目标，促进中风后的运动恢复。为了实现这一点，我建议确定如何动态在一个特定的抑制细胞网络参与运动学习，研究这些动力学是如何被中风破坏，并测试他们的调制是否可以改善恢复。完成本项目将为我提供机会，以填补我目前的技能，并装备我，启动一个独立的恢复神经生理学研究项目。我仔细设计了一个职业发展计划，以解决这些培训差距，通过结合实践实验，课程和教学法，以及来自模范团队的指导在旧金山弗朗西斯科和加州大学旧金山分校的科学家。我的导师团队拥有强大的培训和发展年轻研究人员的记录;以及丰富的研究环境在退伍军人事务部的弗朗西斯科，我将做好充分的准备来完成我的培训目标。的这些实验的结果将导致出版物，并为许多重要的路线铺平道路我将在自己的实验室里进行研究。