Modulating cortical inhibitory networks to facilitate stroke recovery
调节皮质抑制网络以促进中风恢复
基本信息
- 批准号:10591018
- 负责人:
- 金额:$ 22.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-01 至 2023-09-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimalsAreaBrainCalciumCellsClinical TrialsComplexDataElectronic Medical Records and Genomics NetworkEnsureEnvironmentExperimental DesignsFunctional disorderFutureGoalsInvestigationLaboratoriesLearningLeftMentorshipModificationMotor CortexMovementNeuronsPatternPhysiciansPopulationPopulation DynamicsPreparationProgram DevelopmentPublicationsRandomizedReaction TimeRecoveryReproducibilityResearchResearch PersonnelScientistStrokeTestingTrainingTranslatingcalmodulin-dependent protein kinase IIcareer developmentcell cortexcell typecohortdesigndisabilityexcitatory neuronexperimental studyfunctional improvementgraspimaging systemimprovedinhibitory neuroninjury recoveryinsightkinematicslong term recoverymotor behaviormotor function improvementmotor learningmotor recoveryneural circuitneurophysiologyneuroregulationnovel therapeuticsoptogeneticspost strokeprogramsrecruitsexskillsstroke patientstroke recoverystroke therapysupport networktool
项目摘要
PROJECT SUMMARY/ABSTRACT
The overarching goal of this project is to identify new targets for neural circuit modulation to facilitate motor
recovery after stroke. To accomplish this, I propose to identify how dynamics in a specific inhibitory cell network
participates in motor learning, investigate how these dynamics are disrupted by stroke, and test whether their
modulation can improve recovery. Completion of this project will provide me with opportunities to fill key gaps in
my current skillset and equip me to launch an independent research program in the neurophysiology of recovery.
I have carefully designed a career development program to address these training gaps through a combination
of hands-on experimentation, coursework and didactics, and mentorship from an exemplary team of physician
scientists at UCSF. My mentorship team has a strong record of training and developing young investigators;
together with the rich research environment at UCSF, I will be well-equipped to accomplish all of my outlined
training goals. The results from these experiments will lead to publications, culminate in an R01 application, and
pave the way for many important lines of investigation I will pursue in my own laboratory.
项目概要/摘要
该项目的总体目标是确定神经回路调制的新目标,以促进运动
中风后的恢复。为了实现这一目标,我建议确定特定抑制细胞网络中的动态如何
参与运动学习,研究这些动态如何被中风破坏,并测试他们是否
调制可以提高恢复率。该项目的完成将为我提供填补关键空白的机会
我目前的技能使我能够启动恢复神经生理学的独立研究项目。
我精心设计了一个职业发展计划,通过组合来解决这些培训差距
实践实验、课程作业和教学法以及模范医师团队的指导
加州大学旧金山分校的科学家。我的导师团队在培训和培养年轻研究者方面拥有良好的记录;
加上加州大学旧金山分校丰富的研究环境,我将有能力完成我概述的所有目标
培训目标。这些实验的结果将发表,最终形成 R01 应用程序,并且
为我将在自己的实验室中进行的许多重要研究方向铺平道路。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sergio Estevan Arroyo其他文献
Sergio Estevan Arroyo的其他文献
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{{ truncateString('Sergio Estevan Arroyo', 18)}}的其他基金
Modulating cortical inhibitory networks to improve stroke recovery
调节皮质抑制网络以改善中风恢复
- 批准号:
10753362 - 财政年份:2023
- 资助金额:
$ 22.13万 - 项目类别:
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