Modulating cortical inhibitory networks to facilitate stroke recovery

调节皮质抑制网络以促进中风恢复

• 批准号: 10591018
• 负责人: Sergio Estevan Arroyo
• 金额: $ 22.13万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591018
• 关键词: Address; Affect; Animals; Area; Brain; Calcium; Cells; Clinical Trials; Complex; Data; Electronic Medical Records and Genomics Network; Ensure; Environment; Experimental Designs; Functional disorder; Future; Goals; Investigation; Laboratories; Learning; Left; Mentorship; Modification; Motor Cortex; Movement; Neurons; Pattern; Physicians; Population; Population Dynamics; Preparation; Program Development; Publications; Randomized; Reaction Time; Recovery; Reproducibility; Research; Research Personnel; Scientist; Stroke; Testing; Training; Translating; calmodulin-dependent protein kinase II; career development; cell cortex; cell type; cohort; design; disability; excitatory neuron; experimental study; functional improvement; grasp; imaging system; improved; inhibitory neuron; injury recovery; insight; kinematics; long term recovery; motor behavior; motor function improvement; motor learning; motor recovery; neural circuit; neurophysiology; neuroregulation; novel therapeutics; optogenetics; post stroke; programs; recruit; sex; skills; stroke patient; stroke recovery; stroke therapy; support network; tool

PROJECT SUMMARY/ABSTRACT The overarching goal of this project is to identify new targets for neural circuit modulation to facilitate motor recovery after stroke. To accomplish this, I propose to identify how dynamics in a specific inhibitory cell network participates in motor learning, investigate how these dynamics are disrupted by stroke, and test whether their modulation can improve recovery. Completion of this project will provide me with opportunities to fill key gaps in my current skillset and equip me to launch an independent research program in the neurophysiology of recovery. I have carefully designed a career development program to address these training gaps through a combination of hands-on experimentation, coursework and didactics, and mentorship from an exemplary team of physician scientists at UCSF. My mentorship team has a strong record of training and developing young investigators; together with the rich research environment at UCSF, I will be well-equipped to accomplish all of my outlined training goals. The results from these experiments will lead to publications, culminate in an R01 application, and pave the way for many important lines of investigation I will pursue in my own laboratory.

项目总结/文摘