Modulating cortical inhibitory networks to facilitate stroke recovery

调节皮质抑制网络以促进中风恢复

• 批准号: 10591018
• 负责人: Sergio Estevan Arroyo
• 金额: $ 22.13万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591018
• 关键词: Address; Affect; Animals; Area; Brain; Calcium; Cells; Clinical Trials; Complex; Data; Electronic Medical Records and Genomics Network; Ensure; Environment; Experimental Designs; Functional disorder; Future; Goals; Investigation; Laboratories; Learning; Left; Mentorship; Modification; Motor Cortex; Movement; Neurons; Pattern; Physicians; Population; Population Dynamics; Preparation; Program Development; Publications; Randomized; Reaction Time; Recovery; Reproducibility; Research; Research Personnel; Scientist; Stroke; Testing; Training; Translating; calmodulin-dependent protein kinase II; career development; cell cortex; cell type; cohort; design; disability; excitatory neuron; experimental study; functional improvement; grasp; imaging system; improved; inhibitory neuron; injury recovery; insight; kinematics; long term recovery; motor behavior; motor function improvement; motor learning; motor recovery; neural circuit; neurophysiology; neuroregulation; novel therapeutics; optogenetics; post stroke; programs; recruit; sex; skills; stroke patient; stroke recovery; stroke therapy; support network; tool

PROJECT SUMMARY/ABSTRACT The overarching goal of this project is to identify new targets for neural circuit modulation to facilitate motor recovery after stroke. To accomplish this, I propose to identify how dynamics in a specific inhibitory cell network participates in motor learning, investigate how these dynamics are disrupted by stroke, and test whether their modulation can improve recovery. Completion of this project will provide me with opportunities to fill key gaps in my current skillset and equip me to launch an independent research program in the neurophysiology of recovery. I have carefully designed a career development program to address these training gaps through a combination of hands-on experimentation, coursework and didactics, and mentorship from an exemplary team of physician scientists at UCSF. My mentorship team has a strong record of training and developing young investigators; together with the rich research environment at UCSF, I will be well-equipped to accomplish all of my outlined training goals. The results from these experiments will lead to publications, culminate in an R01 application, and pave the way for many important lines of investigation I will pursue in my own laboratory.

项目概要/摘要 该项目的总体目标是确定神经回路调制的新目标，以促进运动 中风后的恢复。为了实现这一目标，我建议确定特定抑制细胞网络中的动态如何 参与运动学习，研究这些动态如何被中风破坏，并测试他们是否 调制可以提高恢复率。该项目的完成将为我提供填补关键空白的机会 我目前的技能使我能够启动恢复神经生理学的独立研究项目。 我精心设计了一个职业发展计划，通过组合来解决这些培训差距 实践实验、课程作业和教学法以及模范医师团队的指导 加州大学旧金山分校的科学家。我的导师团队在培训和培养年轻研究者方面拥有良好的记录； 加上加州大学旧金山分校丰富的研究环境，我将有能力完成我概述的所有目标 培训目标。这些实验的结果将发表，最终形成 R01 应用程序，并且 为我将在自己的实验室中进行的许多重要研究方向铺平道路。