Consensus Workshop to Address Kidney Health in High-Risk Neonatal Intensive Care Unit Graduates

解决高危新生儿重症监护病房毕业生肾脏健康问题的共识研讨会

• 批准号: 10752851
• 负责人: Michelle C Starr
• 金额: $ 1.3万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10752851
• 关键词: Address; Admission activity; Adolescence; Adult; Advocacy; Age; Angiotensin-Converting Enzyme Inhibitors; Area; Blood Pressure Monitors; Caregivers; Caring; Child; Childhood; Chronic Kidney Failure; Clinical Research; Communities; Consensus Workshop; Critical Illness; Development; Disease Progression; Early identification; Educational workshop; End stage renal failure; Family; Fostering; Goals; Grant; Guidelines; Health; Health Services; Heart Diseases; High Prevalence; Intervention; Kidney; Kidney Diseases; Knowledge; Longitudinal Studies; Medical; Methods; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Neonatal; Neonatal Intensive Care Units; Nephrology; Paper; Patient Discharge; Patients; Practice Guidelines; Pregnancy; Prevention; Process; Provider; Publishing; Quality of life; Recommendation; Renal function; Research; Research Infrastructure; Research Personnel; Research Priority; Risk; Sepsis; Testing; United States National Institutes of Health; Voting; Work; care providers; clinical care; clinical practice; congenital heart disorder; disorder risk; extreme prematurity; follow-up; high risk; high risk population; improved; interest; meetings; neonatal hypoxic-ischemic brain injury; neonate; pediatrician; premature; preterm newborn; prevent; renal damage; working group

Chronic kidney disease (CKD) is common in neonates who require care in the Neonatal Intensive Care Unit (NICU), particularly in premature neonates, critically ill neonates, and those with congenital heart disease. Studies of long-term kidney function in children born prematurely show a threefold increase in CKD by adolescence and into adulthood. The burden of CKD will continue to increase as more extremely preterm neonates survive into adulthood and the threshold of viability continues to decrease beyond 22 weeks’ gestation. Despite the known CKD risk for neonates discharged from the NICU, no current recommendations outline who should be monitored for CKD, when they should be monitored, or what types of testing should be performed for kidney health monitoring. Furthermore, there is a gap in our understanding of the necessary next steps and opportunities in neonatal nephrology research and clinical care, which contributes to a lack of momentum in the neonatal nephrology community. To fill key these knowledge gaps, we propose the “Consensus Workshop to Address Kidney Health in High-Risk Neonatal Intensive Care Unit Graduates” with the following aims: 1) To develop expert-based guidance on kidney health monitoring after NICU discharge for three high-risk neonatal groups, 2) Identify gaps in neonatal nephrology research and clinical care, focusing on kidney health and CKD after NICU discharge, and 3) Develop working groups to begin to close these gaps in neonatal nephrology, focusing on kidney health and CKD after NICU discharge. Successful completion of this Workshop will result in the development of recommendations to assist clinicians in determining who, when, and how to evaluate kidney health in NICU graduates. These recommendations will not only allow for improvements in clinical care, but they will also help improve how we perform research. We will also identify research and clinical care priorities in neonatal nephrology, focusing on kidney health and CKD risk in NICU graduates. Finally, we will develop Collaborative Research Groups to build upon the prioritization areas in neonatal nephrology that are identified during the Workshop, and allow for conversations on how to address these gaps. The end product will be the establishment of research infrastructure, which will set the stage for grant submission to NIH. The work that will be accomplished during the workshop is essential to future research through NIH as pragmatic clinical studies and multicenter collaborative work requires a shared understanding of best practices when it comes to kidney health monitoring. This Workshop will bring together a diverse and representative group of pediatric and adult nephrologists, neonatologists, cardiologists, intensivists, pediatricians, health service researchers, patients and families, and advocacy experts to accomplish the above aims. Furthermore, by involving trainees actively in the development of follow-up guidelines, identification of research and clinical care gaps, and formation of collaborative working groups, we strive to further develop the research pipeline in the neonatal nephrology field.

慢性肾脏疾病(CKD)在新生儿重症监护病房需要护理的新生儿中很常见 新生儿重症监护病房(NICU)，特别是早产儿、危重新生儿和先天性心脏病患者。 对早产儿长期肾功能的研究表明，早产儿慢性肾脏病增加了三倍 青春期和成年期。CKD的负担将继续增加，因为越来越多的早产儿 新生儿存活到成年，存活门槛在怀孕22周后继续下降。 尽管从NICU出院的新生儿存在CKD的已知风险，但目前没有任何建议概述谁 应对CKD进行监控，应在何时对其进行监控，或应对哪些类型的测试执行 肾脏健康监测。此外，我们对必要的下一步和 在新生儿肾病研究和临床护理方面的机会，这导致了 新生儿肾病社区。为了填补这些关键的知识空白，我们提议举行“共识研讨会”，以 解决高危新生儿重症监护病房毕业生的肾脏健康问题“，目标如下：1) 为三名高危新生儿NICU出院后肾脏健康监测提供专家指导 小组，2)找出新生儿肾病研究和临床护理方面的差距，重点关注肾脏健康和慢性肾脏病 在NICU出院后，以及3)建立工作组，开始弥合新生儿肾病方面的这些差距， 重点关注NICU出院后的肾脏健康和CKD。本研讨会的圆满完成将导致 帮助临床医生确定谁、何时和如何评估肾脏的建议的制定 NICU毕业生的健康状况。这些建议不仅将改善临床护理，而且它们 也将有助于改善我们进行研究的方式。我们还将确定研究和临床护理的优先事项 新生儿肾病，重点关注NICU毕业生的肾脏健康和慢性肾脏病风险。最后，我们将发展 协作研究小组在确定的新生儿肾病优先领域的基础上再接再厉 在讲习班期间，并允许就如何消除这些差距进行对话。最终产品将是 建立研究基础设施，这将为向NIH提交拨款奠定基础。这项工作将 在研讨会期间完成是通过NIH作为务实的临床研究的未来研究必不可少的 多中心协作工作需要对肾脏方面的最佳实践有共同的理解 运行状况监测。这次研讨会将汇集不同的、具有代表性的儿科和成人群体 肾病学家、新生儿科医生、心脏病专家、重症医生、儿科医生、卫生服务研究人员、患者和 家庭，以及宣传专家，以实现上述目标。此外，通过让受训人员积极参与 制定后续指南，确定研究和临床护理差距，并形成 通过合作工作组，我们努力进一步发展新生儿肾病领域的研究流水线。