Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases

肺生物学和肺部疾病中的干细胞、细胞疗法和生物工程

• 批准号: 10753310
• 负责人: Amy Leanne Ryan
• 金额: $ 3.5万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753310
• 关键词: 3-Dimensional; Address; American; Animal Model; Area; Award; Basic Science; Biology; Biomedical Engineering; Blinded; Career Mobility; Cell Therapy; Cells; Chest; Clinic; Clinical; Clinical Research; Communication; Communities; Critical Illness; Cystic Fibrosis; Data; Development; Disease; European; Event; Faculty; Fostering; Foundations; Funding; Funding Agency; Funding Opportunities; Future; Goals; Grant; Growth; Guidelines; Hybrids; Immune response; Injury; International; Journals; Lung; Lung diseases; Mentors; Molecular; Motivation; National Heart, Lung, and Blood Institute; Natural regeneration; Oral; Participant; Pathologic; Persons; Physiology; Postdoctoral Fellow; Pre-Clinical Model; Publishing; Pulmonary Fibrosis; Recommendation; Regulation; Research; Research Personnel; Research Support; Respiratory Disease; Role; Science; Series; Societies; Stem Cell Research; Students; Therapeutic; Time; Tissue Engineering; Training; Translating; Translational Research; Transplantation; Travel; Underrepresented Minority; Underrepresented Populations; United States National Aeronautics and Space Administration; United States National Institutes of Health; Universities; Vermont; Woman; Women' s Group; airway regeneration; career development; combat; design; graduate student; immunoregulation; induced pluripotent stem cell; innovation; insight; lung development; lung injury; lung regeneration; meetings; phrases; postdoctoral investigator; posters; programs; repaired; respiratory; scaffold; scientific organization; skill acquisition; stem cells; symposium; technology/technique; translational study

Project Summary Repair and regeneration of a diseased lung with stem cells or bioengineered tissues are exciting potential therapeutic approaches for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence in preclinical models suggests that cells which are not normally resident in the lung can be utilized to modulate immune responses after injury, but there have been challenges in translating these promising findings to the clinic. In parallel, there has been a surge in bioengineering studies investigating use of artificial and acellular lung matrices as scaffolds for three-dimensional lung or airway regeneration, with some recent attempts of transplantation in large animal models. The combination of these studies with those utilizing stem cells, induced pluripotent stem cell derivatives, and/or cell therapies is a promising and rapidly developing research area. These studies have been further paralleled by significant increases in understanding the molecular and cellular events by which endogenous lung stem and/or progenitor cells arise and differentiate during lung development and in normal and pathologic repair and remodeling after lung injury. We have held nine previous biennial conferences at the University of Vermont from 2005 through 2021. The previous conferences, and the planned 2023 conference, have filled an important niche in the rapidly moving fields of stem cells, cell therapies, lung biology, and bioengineering. Conducted in the style of the Gordon Conferences, there are no other comparable meetings that allow the depth and breadth of discussion, deliberation, and connection that occurs. Importantly, in addition to participation by leading figures in lung biology and disease, we have regularly attracted prominent (non-lung) stem cell experts to give featured plenary presentations, bringing innovation into the field. This is an important feature of the program and is a continuing mark of the stature and importance of the conference. These conferences have been highly successful and have resulted in a series of guidelines for basic, translational, and clinical research to be utilized by both investigators and funding agencies. As studies on stem cell and cell therapies for lung diseases continues to move at a rapid pace and the field explores how to best translate these approaches, we propose to again convene the relevant investigators as well as representatives from the NHLBI, FDA, and leading non-profit respiratory disease foundations to discuss current issues. As always, junior investigators, trainees, and investigators from underrepresented groups will be prioritized for inclusion in conference organization, oral presentations, chairing activities, discussions, and poster sessions. Trainees will be able to compete for an increased number of travel awards based on blinded review of submitted abstracts. The conference is planned as an in-person event with a hybrid online option to increase participation of underrepresented minorities and overseas students in July 2023 at the University of Vermont. We anticipate that this conference will continue to foster extensive discussion and debate and will significantly guide directions in basic, translational, and clinical research of stem cells, cell therapies, and bioengineering approaches for lung diseases.

项目摘要 用干细胞或生物工程组织修复和再生患病的肺是令人兴奋的潜力 各种肺部疾病和危重疾病的治疗方法。在过去的十年里，越来越多的 临床前模型中的证据表明，非正常驻留在肺中的细胞可以用于 调节损伤后的免疫反应，但在翻译这些有希望的发现方面一直存在挑战 去诊所。与此同时，研究人工和生物工程技术使用的生物工程研究激增。 无细胞肺基质作为三维肺或呼吸道再生支架，最近进行了一些尝试 在大型动物模型中进行移植的可能性。这些研究与那些利用干细胞的研究相结合， 诱导多能干细胞衍生品和/或细胞疗法是一个很有前途且发展迅速的研究。 区域。与这些研究进一步平行的是，对分子和分子的理解显著增加 内源性肺干细胞和/或祖细胞在肺内产生和分化的细胞事件 在肺损伤后的正常和病理修复和重塑中。我们已经举办了九次 2005年至2021年在佛蒙特大学举行两年一次的会议。以前的会议，以及 计划于2023年召开的会议，填补了干细胞、细胞疗法、 肺部生物学和生物工程。以戈登会议的风格进行，没有其他 类似的会议，允许进行深度和广度的讨论、审议和联系。 重要的是，除了肺部生物学和疾病领域的领军人物参与外，我们还经常吸引 杰出的(非肺脏)干细胞专家将发表专题全体报告，将创新带入该领域。 这是该计划的一个重要特点，也是该计划地位和重要性的持续标志 会议。这些会议非常成功，并产生了一系列基本的、 研究人员和资助机构都将利用转译和临床研究。关于茎的研究 肺部疾病的细胞和细胞疗法继续快速发展，该领域探索如何最好地 翻译这些方法，我们建议再次召集相关调查人员以及代表 来自NHLBI、FDA和领先的非营利性呼吸道疾病基金会讨论当前的问题。AS 通常，初级调查人员、实习生和来自代表性不足群体的调查人员将被优先考虑 参与会议组织、口头陈述、主持活动、讨论和海报会议。 学员将能够在盲目审查提交的基础上竞争更多的旅行奖励 摘要。会议计划为面对面活动，并提供混合在线选项以增加参与度 2023年7月，佛蒙特州大学对未被充分代表的少数民族和留学生进行了调查。我们期待着 本次会议将继续促进广泛的讨论和辩论，并将在很大程度上指导方向 肺干细胞、细胞疗法和生物工程方法的基础、翻译和临床研究 疾病。