Octapeptin-based Antibiotics Against Multi-drug Resistant Gram-negative Bacteria

针对多重耐药革兰氏阴性菌的八肽素抗生素

• 批准号: nhmrc : 1045326
• 负责人: Dr Bernd Becker
• 金额: $ 51.18万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/octapeptin-based-antibiotics-negative-bacteria/111737
• 关键词: Octapeptin; based; Antibiotics; Against; Multi

Infectious disease is a leading cause of death, and the emergence of "superbugs" in the community and hospitals is of grave concern. We have resurrected a ‘forgotten’ antibiotic from the 1970s that kills superbugs causing pneumonia, skin and urinary track infections; diseases that cause death and discomfort for thousands of Australians today. We will determine how the original antibiotic works against superbugs, and use this information to design better drugs for the future.

传染病是导致死亡的主要原因，社区和医院中出现的“超级细菌”令人严重关切。我们复活了一种20世纪70年代被“遗忘”的抗生素，这种抗生素可以杀死导致肺炎、皮肤和尿道感染的超级细菌;这些疾病导致今天成千上万的澳大利亚人死亡和不适。我们将确定最初的抗生素如何对抗超级细菌，并利用这些信息为未来设计更好的药物。