ARDS - EDEN Protocol

ARDS - EDEN 协议

• 批准号: 7824246
• 负责人: NEIL R MACINTYRE
• 金额: $ 30.68万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7824246
• 关键词: ARDS; EDEN; Protocol

¿ Objectives: 1. To assess the safety and efficacy of initial trophic enteral feeding followed by advancement to full-calorie enteral feeding vs. initial advancement to full-calorie enteral feeding management strategies in reducing mortality and morbidity in patients with ALI or ARDS ¿ Hypotheses: 1. Initial trophic feeding followed by full-calorie enteral feeding will improve clinical outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as compared to early, full-calorie enteral feeding.

目标： 1.评估初始营养性肠内喂养随后推进至全热量肠内喂养与初始推进至全热量肠内喂养管理策略在降低ALI或ARDS患者死亡率和发病率方面的安全性和有效性 假设： 1.与早期全热量肠内喂养相比，初始营养喂养后的全热量肠内喂养将通过减少全身炎症和喂养并发症的数量来改善ALI或ARDS患者的临床结局（特别是增加至第28天的无呼吸机天数，并降低60天的住院死亡率）。