ARDS - EDEN OMEGA Protocol

？目标： 1.评估在ALI或ARDS患者中，先进行营养肠内喂养，然后进行全热量肠内喂养与最初进行全热量肠内喂养相比，在降低死亡率和发病率方面的安全性和有效性。 2.评估omega-3脂肪酸、γ-亚麻酸和抗氧化剂补充在降低ALI或ARDS患者死亡率和发病率方面的安全性和有效性。 ？假设： 1.与早期的全卡路里肠内喂养相比，通过减少全身炎症和喂养并发症的数量，最初的营养喂养和全热量肠内喂养将改善ALI或ARDS患者的临床结果(特别是将无呼吸机天数增加到第28天，并降低60天的住院死亡率)。 2.与安慰剂相比，omega-3脂肪酸、伽马-亚麻酸(GLA)和抗氧化剂补充剂将通过减轻全身炎症，改善ALI或ARDS患者的临床结果(特别是增加到第28天的无呼吸机天数，并降低60天的住院死亡率)。

¿ Objectives: 1. To assess the safety and efficacy of initial trophic enteral feeding followed by advancement to full-calorie enteral feeding vs. initial advancement to full-calorie enteral feeding management strategies in reducing mortality and morbidity in patients with ALI or ARDS 2. To assess the safety and efficacy of omega-3 fatty acid, gamma-linolenic acid, and anti-oxidant supplementation in reducing mortality and morbidity in patients with ALI or ARDS ¿ Hypotheses: 1. Initial trophic feeding followed by full-calorie enteral feeding will improve clinical outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as compared to early, full-calorie enteral feeding. 2. Omega-3 Fatty Acid, Gamma-linolenic acid (GLA), and anti-oxidant supplementation, as compared to placebo, will improve clinical outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by attenuating systemic inflammation.