BONE DENSITY IN CHILDHOOD STUDY - CLINICAL CENTER

儿童骨密度研究（BMDCS）的目的是在考虑骨骼成熟度、骨大小和体积、体型和青春期阶段的情况下，获得标准的参考骨密度测量。这些数据将作为一个非常有价值的标准儿科骨密度数据库。它有望成为重要的参考，将使儿科医生研究，诊断和治疗儿童疾病影响骨积累。临床中心和数据协调中心的六份合同于2001年8月1日授予。这五个学术临床中心都遵循一个共同的纵向观察方案，包括基线和连续三次的年度评估，包括双x线吸收仪（DXA）和骨龄x线，一次身体检查，以确定他们的青春期状态、身高、体重和身体质量指数（BMI）。此外，三个站点正在对一部分儿童进行CT或pQCT扫描。每年从每个儿童那里获得有关骨骼健康的信息，如饮食和运动。骨龄x线和DXA扫描集中解释。2002年7月，五个临床中心开始招募，到2003年11月1日，共有1554名6-16岁的男女和所有种族的儿童入组。

The purpose of the bone mineral density in childhood study (BMDCS) is to obtain standard reference bone mineral density measures taking into consideration skeletal maturation, bone size and volume, body size, and pubertal stage. These data will serve as an extremely valuable standard pediatric BMD database. It is anticipated to become the essential reference that will enable pediatricians to study, diagnose, and treat children with disorders affecting bone accrual. The six contracts for the Clinical Centers and the Data Coordinating Center were awarded on August 1, 2001. The five academic clinical centers all adhere to a common longitudinal observational protocol involving a baseline and three consecutive annual evaluations, including dual x-ray absorptiometry (DXA) and bone age x-ray, a physical exam to determine their pubertal status, stadiometer height, weight, and body mass index (BMI). Additionally, three sites are performing CT or pQCT scans on a subset of children. Information relating to bone health such as diet and exercise is obtained from each child annually. The bone age x-ray and DXA scans are interpreted centrally. Recruitment commenced in July 2002 at five Clinical Centers and resulted in the enrollment by November 1, 2003 of 1554 children from 6-16 years old of both genders and all racial groups.