BONE MINERAL DENSITY IN CHILDHOOD STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 BMDCS是一项为期3年的纵向研究，对登记时6至16岁的1530名健康儿童和青少年的种族差异队列中的骨量增加进行研究。BMDCS的目标是通过双能X射线吸收法(DXA)获得与年龄、身体大小、骨骼发育和性成熟有关的骨矿化的儿科标准。将获得骨矿化的纵向测量，以便建立从儿童到青春期的正常骨矿积累量范围。受试者将在为期12个月的时间里在美国的五个临床中心招募：哥伦比亚大学、费城儿童医院、辛辛那提儿童医院、克雷顿大学和洛杉矶儿童医院。儿童将在经过详细筛查后被纳入研究，以确保他们具有正常的生长和成熟，并且不存在已知的影响骨矿化的因素。骨量和密度将在基线时用DXA测量，然后每年测量一次，持续三年。将获得全身、左髋关节、腰椎和非优势前臂的DXA扫描。手腕X光骨龄测定和生长和青春期成熟的详细测量将与DXA测量相结合。每次访问也将获得有关体力活动、饮食摄入量和一般健康的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The BMDCS is a 3-year longitudinal study of bone mass accretion in an ethnically diverse cohort of 1530 healthy children and adolescents between 6 and 16 years of age at enrollment. The goal of the BMDCS is to obtain pediatric standards for bone mineralization by dual energy x-ray absorptiometry (DXA) in relation to age, body size, skeletal development and sexual maturation. Longitudinal measures of bone mineralzation will be obtained so that normal ranges of bone mineral accrual through childhood and adolescence can be established. Subjects will be recruited over a 12-month period at five clinical centers in the U.S.: Columbia University, Children's Hospital of Philadelphia, Cincinnati Children's Hospital, Creighton University, and Children's Hospital, Los Angeles. Children will be enrolled in the study after a detailed screening to ensure that they have normal growth and maturation and are free of factors known to affect bone mineralization. Bone mass and density will be measured by DXA at baseline and then annually for three years. DXA scans will be obtained of the total body, left hip, lumbar spine and non-dominant forearm. A hand wrist x-ray for bone age determination and detailed measurements of growth and pubertal maturation will be obtained in conjunction with the DXA measurements. Information on physical activity, dietary intake and general health also will be obtained at each visit.