BONE MINERAL DENSITY IN CHILDHOOD STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 BMDCS是一项在1530名6 - 16岁健康儿童和青少年中进行的为期3年的骨量增长纵向研究。BMDCS的目标是通过双能X线吸收测定法（DXA）获得与年龄、体型、骨骼发育和性成熟相关的儿童骨矿化标准。将获得骨矿化的纵向测量结果，以便建立儿童期和青春期骨矿物质增加的正常范围。 受试者将在12个月内在美国的5个临床中心招募： 哥伦比亚大学、费城儿童医院、辛辛那提儿童医院、克雷顿大学和洛杉矶儿童医院。 儿童将在详细筛选后入组研究，以确保他们正常生长和成熟，并且没有已知影响骨矿化的因素。将在基线时通过DXA测量骨量和密度，然后每年测量一次，持续3年。 将获得全身、左髋、腰椎和非优势前臂的DXA扫描。 一只手 将结合DXA测量获得用于骨龄测定的腕部X射线和生长和青春期成熟的详细测量。 每次访视时还将获得有关体力活动、饮食摄入和一般健康状况的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The BMDCS is a 3-year longitudinal study of bone mass accretion in an ethnically diverse cohort of 1530 healthy children and adolescents between 6 and 16 years of age at enrollment. The goal of the BMDCS is to obtain pediatric standards for bone mineralization by dual energy x-ray absorptiometry (DXA) in relation to age, body size, skeletal development and sexual maturation. Longitudinal measures of bone mineralzation will be obtained so that normal ranges of bone mineral accrual through childhood and adolescence can be established. Subjects will be recruited over a 12-month period at five clinical centers in the U.S.: Columbia University, Children's Hospital of Philadelphia, Cincinnati Children's Hospital, Creighton University, and Children's Hospital, Los Angeles. Children will be enrolled in the study after a detailed screening to ensure that they have normal growth and maturation and are free of factors known to affect bone mineralization. Bone mass and density will be measured by DXA at baseline and then annually for three years. DXA scans will be obtained of the total body, left hip, lumbar spine and non-dominant forearm. A hand wrist x-ray for bone age determination and detailed measurements of growth and pubertal maturation will be obtained in conjunction with the DXA measurements. Information on physical activity, dietary intake and general health also will be obtained at each visit.