MESA

台面

• 批准号: 7917736
• 负责人: KIANG JOHN LIU
• 金额: $ 293.45万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2015-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7917736
• 关键词: MESA

The Northwestern University serves as one of six Field Centers for the Multi-Ethnic Study of Atherosclerosis (MESA), a study of the correlates, predictors and progression of subclinical cardiovascular disease (CVD) (disease detected non-invasively before it has produced clinical signs and symptoms) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. Six thousand eight hundred and fourteen (6,814) participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tomometry, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, nutritional and environmental characteristics; and genetic factors. Selected components were repeated over three subsequent examinations through 2007. The cohort has been followed for clinical events since baseline to ascertain and characterize new clinical events and other changes in health status, including changes in medications. The four scientific objectives for the period 2008 through 2015 are (1) identify factors related to progression of subclinical to clinical CVD; (2) identify predictors of decline in ventricular function; (3) further understanding of the basis for racial/ethnic difference in CVD; and (4) provide a platform for in-depth ancillary studies of CVD and other areas. All surviving and willing members of the MESA cohort will be followed up during the time period and included in an fifth examination during 2010-2012. The study will support in-depth ancillary studies that are funded outside of the current contracts. These studies will be operationally integrated into the main study, and the data will be shared across both types of studies, per current MESA and NIH data-sharing policies. The study¿s data will be provided to interested investigators through a defined process that encourages maximum data utilization but that protects participant confidentially. The study will also serve as a training ground for junior investigators, who will work with senior investigators and be provided with access to the MESA data set and guidance on conducting research. The MESA-EYE component (refraction and fundus photography) was integrated into the second MESA visit in which 6235 people participated between September 2002 and December 2003. The aims of the ocular component were to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. Analyses of various ocular phenotypes, including retinal microvascular disease in MESA Family¿s ancillary study.

西北大学是动脉粥样硬化多种族研究 (MESA) 的六个现场中心之一，MESA 是一项针对亚临床心血管疾病 (CVD)（在产生临床体征和症状之前通过非侵入性方式检测到的疾病）的相关性、预测因素和进展的研究，对象为 45-84 岁的男性和女性，基线时没有临床 CVD 证据。 2000-2002 年期间，从六个现场中心招募了六千八百一十四 (6,814) 名参与者，并使用计算机断层扫描、心脏 MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉断层扫描、踝肱指数测量和视网膜摄影检查亚临床冠状动脉粥样硬化的证据，并在亚组中使用腹部检查 主动脉 CT、颈动脉 MRI、心脏 MRI 标记，用于测量局部心肌功能；已建立的和假定的实验室风险标记；社会经济、心理、行为、营养和环境特征；和遗传因素。选定的组成部分在 2007 年的三项后续检查中重复进行。自基线以来一直对队列进行临床事件跟踪，以确定和表征新的临床事件和健康状况的其他变化，包括药物的变化。 2008 年至 2015 年期间的四个科学目标是 (1) 确定与亚临床向临床 CVD 进展相关的因素； (2) 确定心室功能下降的预测因素； (3)进一步了解CVD种族/民族差异的基础； (4)为CVD等领域的深入辅助研究提供平台。所有幸存且愿意的 MESA 队列成员将在此期间接受随访，并纳入 2010-2012 年第五次检查。该研究将支持在当前合同之外资助的深入辅助研究。这些研究将在操作上整合到主要研究中，并且根据当前的 MESA 和 NIH 数据共享政策，数据将在两种类型的研究之间共享。该研究的数据将通过规定的流程提供给感兴趣的研究人员，该流程鼓励最大程度地利用数据，同时保护参与者的机密。该研究还将作为初级研究人员的培训基地，他们将与高级研究人员合作，并获得 MESA 数据集的访问权限和开展研究的指导。 MESA-EYE 部分（验光和眼底照相）被纳入第二次 MESA 就诊，其中 2002 年 9 月至 2003 年 12 月期间有 6235 人参加。眼部部分的目的是记录表明黄斑变性和糖尿病性视网膜病变的视网膜微血管变化（根据数字视网膜照片解释）的存在和严重程度，以及描述它们与横截面和视网膜病变的相互关系。 通过成像方式或生物实验室测量分析，对临床定义的微血管和大血管系统性疾病进行纵向测量。视敏度/客观屈光部分的设计目的是让我们能够根据性别和种族估计视力障碍，确定通过更好的屈光矫正可以减少视力障碍的程度，并将视觉结果与视网膜病理相关联。 MESA Family 辅助研究中对各种眼部表型的分析，包括视网膜微血管疾病。