Peripheral Processing and Coding of Gustatory Input

味觉输入的外围处理和编码

基本信息

批准号：
7902652
负责人：
Vonnie D.C. Shields
金额：
$ 3.55万
依托单位：
TOWSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-14 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7902652
关键词：
Acids Address Alkaloids Allelochemicals Animals Behavior Behavioral Biological Assay Brain Cells Characteristics Chemicals Code Complex Coumarins Decision Making Diet Edible Plants Face Feeding behaviors Food Goals Gypsies Housing Human Individual Insecta Larva Lateral Medial Methods Modeling Molecular Morphology Moths Neurobiology Neurons Organ Peripheral Physiological Phytochemical Plants Play Positioning Attribute Principal Investigator Process Property Quinones Receptor Cell Research Role Saponin Saponins Scanning Electron Microscopy Sensory Signal Transduction Source Stimulus System Tannic Acid Taste Perception Terpenes Testing Transmission Electron Microscopy alpha benzopyrone base feeding insight multidisciplinary nerve supply neuromechanism neuronal patterning neurophysiology performance site receptor relating to nervous system research study response sensory system

项目摘要

EXCEED THE SPACE PROVIDED. The goal of this application is to understand the processing and coding of natural taste stimuli by gustatory receptor cells that are housed in taste organs on the mouthparts of an insect model. Gustatory receptor cells constitute a sensory filter for environmental taste signals and in insects, they transfer information about taste stimuli directly to taste centers in the brain. Therefore, gustatory receptor cells form the first layer of a decision making process that ultimately determines whether food is accepted or rejected by the animal. The major premise of this research is that we know very little about the neural mechanisms that underlie feeding, specifically the ultrastructural organization of the taste apparatus, the neural coding of taste stimuli, or the feeding behavior evoked by these stimuli. The gustatory organs of caterpillars provide an excellent system to address questions about the taste system. These organs form a relatively simple sensory system. Two gustatory organs, each with four putative gustatory receptor cells, are thought to respond to stimuli in different behavioral or ecological contexts. However, taste stimuli can be fairly complex because they can be composed of multimolecular mixtures. The animal faces the task to decipher individual tastants and then to make an appropriate feeding choice. Our research strategy is to first describe the cellular and subcellular organization of taste organs and receptor cells therein. In a second step, we will use feeding behavioral bioassays to test which taste stimuli evoke feeding or food rejection. In a third step, we describe the neural responses of gustatory receptor cells to selected individual taste stimuli, as well as to mixtures, and will correlate the neural and behavioral responses. These studies will provide insights into peripheral taste processing from molecules to behavior in an unprecedented manner. PERFORMANCE SITE ========================================Section End===========================================

超过提供的空间。该应用的目的是了解昆虫模型口中味道器官中的味觉受体细胞对自然口味刺激的加工和编码。味觉受体细胞构成了一种用于环境口味信号和昆虫的感觉过滤器，它们将有关味觉刺激的信息直接传递到大脑的口味中心。因此，味觉受体细胞构成了决策过程的第一层，该过程最终确定食物是被动物接受还是被动物拒绝。这项研究的主要前提是，我们对喂养饲料的神经机制，特别是味觉设备的超微结构组织，味觉刺激的神经编码或这些刺激引起的喂养行为的了解知之甚少。毛毛虫的味道器官提供了一个很好的系统，可以解决有关味觉系统的问题。这些器官形成一个相对简单的感觉系统。在不同的行为或生态环境中，两个味觉器官都被认为对刺激有反应。但是，味道刺激可能是相当复杂的，因为它们可以由多分子混合物组成。动物面临破译单个味道的任务，然后做出适当的喂养选择。我们的研究策略是首先描述其中的味觉器官和受体细胞的细胞和亚细胞组织。在第二步中，我们将使用喂养行为生物测定法来测试哪种刺激引起喂养或食物排斥。在第三步中，我们描述了味觉受体细胞对选定的单个味道刺激以及混合物的神经反应，并将与神经和行为反应相关联。这些研究将以前所未有的方式对从分子到行为的外围味道加工的见解。表演站点=============================================================================================