Methyl Mercury Effects on Adolescent Development

甲基汞对青少年发育的影响

• 批准号: 7900753
• 负责人: PHILIP W DAVIDSON
• 金额: $ 28.18万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-06 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900753
• 关键词: 15 year old; 16 year old; Adolescence; Adolescent; Adolescent Development; Adopted; Adverse effects; Affect; Age; Age-Months; Air; Animals; Attention; Auditory; Behavioral; Birth; Brain; Brain region; Caring; Child; Child Development; Child health care; Childhood; Cognition; Cohort Studies; Collaborations; Communicable Diseases; Complex; Consumption; Data; Development; Diet; Dose; Eating; Economics; Education; Educational process of instructing; Employee Strikes; English Language; Enrollment; Environment; Epidemiologic Studies; Evaluation; Exposure to; Faeroe Islands; Female; Fishes; Government; Hair; Health; Human; Human Resources; Industrial fungicide; Infant Mortality; Intake; Investigation; Language; Language Tests; Lead; Lead Poisoning; Left; Life; Long-Term Effects; Longitudinal Studies; Mammals; Maternal Exposure; Maternal and Child Health; Measures; Memory; Mercury; Modification; Mothers; Neurocognitive; Neurologic; Oceans; Operative Surgical Procedures; Oral; Outcome; Perinatal; Pesticides; Polychlorinated Biphenyls; Population; Positioning Attribute; Prefrontal Cortex; Pregnancy; Preventive; Process; Public Policy; Recording of previous events; Regression Analysis; Relative (related person); Reporting; Research; Research Personnel; Risk; School-Age Population; Schools; Sea; Sensory; Sentinel; Seychelles; Social Functioning; Soil; Staging; Subgroup; Surveys; Testing; Time; Toxic effect; Training; Uncertainty; United States; United States Environmental Protection Agency; Visit; Water; Whole Blood; absorption; base; cohort; falls; follow-up; foster child; male; member; neurotoxic; neurotoxicity; pollutant; postnatal; prenatal; prenatal exposure; programs; psychologic; public education; social; success; vapor; young adult

This proposal is a competing renewal of Project #5-R01ES08442, entitled Developmental Toxicity of Methyl Mercury, testing the hypothesis that adverse developmental outcomes in children are associated with exposure to methyl mercury (MeHg) from consumption of a diet high in fish. Since 1989, the Seychelles Child Development Study (SCDS) has been following a cohort of 711 children born to mothers who consumed an average of 12 fish-meals per week during pregnancy. The children are now adolescents. The question of whether exposure to MeHg from fish consumption adversely affects child and adolescent development has aroused deepening public concern. The emphasis on prenatal exposures has left several important scientific questions unresolved. Exposure does not cease at birth, yet we know little about the long- term effects of postnatal dietary exposure to MeHg from fish consumption. Also, almost nothing is known about the contributions to long-term outcomes of combined prenatal and postnatal exposure to MeHg. The current proposal aims to determine the consequences of combined prenatal and postnatal exposure especially for long-term or delayed effects that might appear as the children mature. We will examine functions within three major developmental domains: complex cognition, sensory and neuromotor functions, and social- behavioral outcomes in adolescence. The SCDS cohort will be examine once when they are 15 years old and the second when they are 17 years using a combination of psychological and neurological tests and surveys. Prenatal exposure to MeHg was determined by cold vapor atomic absorption from maternal hair collected at enrollment. We will continue to collect child hair at each visit (as has occurred for each of the past five visits) to estimate both average postnatal exposure across ages, and recent exposure. Multiple regression analyses will be used to assess associations between prenatal and postnatal exposure and each endpoint. If we find delayed neurotoxic effects of MeHg in adolescence, substantial or even radical modifications would be required in how we interpret associations between prenatal and postnatal exposure to MeHg and the trajectory of later health consequences.

本提案是项目#5-R 01 ES 08442的竞争性更新，标题为甲基的发育毒性 汞，检验儿童不良发育结果与 由于食用大量鱼类而接触甲基汞。自1989年以来，塞舌尔 儿童发展研究（SCDS）一直在跟踪一组711名儿童，这些儿童的母亲 怀孕期间平均每周吃12顿鱼餐。孩子们现在是青少年。的 食用鱼类接触甲基汞是否会对儿童和青少年产生不利影响的问题 发展引起了公众的日益关注。对产前暴露的强调使一些 重要的科学问题尚未解决。出生时接触并没有停止，但我们对长期的接触知之甚少。 出生后通过食用鱼摄入甲基汞的长期影响。此外，几乎没有什么是已知的 关于产前和产后同时接触甲基汞对长期结果的影响。的 目前的建议旨在确定产前和产后联合暴露的后果， 对于长期或延迟的影响，可能会出现随着儿童的成熟。我们将检查内部的功能 三个主要的发展领域：复杂的认知，感觉和神经运动功能，以及社会- 青春期的行为结果。SCDS队列将在他们15岁时进行一次检查， 第二次是当他们17岁时，使用心理和神经测试和调查相结合的方法。 采用冷原子吸收法从母亲的头发中收集甲基汞， 招生我们将继续在每次访视时收集儿童毛发（与过去5次访视中的每次访视一样） 估计各年龄段的平均产后接触量和近期接触量。多元回归分析 将用于评估产前和产后暴露与每个终点之间的关联。如果我们找到 甲基汞在青春期的延迟神经毒性作用， 在我们如何解释产前和产后接触甲基汞与轨迹之间的关联时， 以后的健康后果。