A Targeted Decision Aid to Improve Minority Participation in Clinical Trials
提高少数群体参与临床试验的有针对性的决策辅助工具
基本信息
- 批准号:7861076
- 负责人:
- 金额:$ 84.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-28 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAfrican AmericanAttitudeAwarenessBeliefBenefits and RisksCancer PatientCancer SurvivorClassificationClinicalClinical TrialsCommunicationCommunitiesComplexDatabasesDecision AidDecision MakingDevelopmentEducationEffectivenessEnrollmentEthnic groupEvaluationFamilyFamily memberFrightGoalsGoldHealthHealth PersonnelHealthcareHealthcare SystemsHispanicsIncidenceIndividualInformed ConsentInterventionInterviewKnowledgeLeadMalignant NeoplasmsMalignant neoplasm of prostateMedicalMinorityMinority GroupsOnline SystemsOutcomeParticipantPatient RecruitmentsPatientsPhysiciansPopulationProceduresPublic HealthQuality of CareRaceRandomized Clinical TrialsResearchResourcesReview LiteratureScreening procedureSelf EfficacySeriesTestingTrustUnited States National Institutes of HealthWorkcostdesignempoweredethnic minority populationexpectationimprovedinnovationinterestnovel strategiespatient populationpopulation basedprogramsracial and ethnicracial and ethnic disparitiessystematic reviewweb site
项目摘要
DESCRIPTION (provided by applicant): Randomized clinical trials are the gold standard for evaluation of medical interventions. However, recruitment of patients, particularly minorities, into trials is often difficult. Slow and non-representative trial accrual delays the assessment and introduction of new treatments, increases the cost, and reduces the generalizability of trials. Despite a growing number of programs and websites are providing information on clinical trials (two examples are the National Institutes of Health Clinical Trials Education Series website, and the National Medical Association's Project I.M.P.A.C.T. (Increase Minority Participation and Awareness of Clinical Trials)), there has been little progress in improving minority participation. Thus, we believe that a novel approach, which targets the specific concerns and knowledge needs of minorities, and which empowers them to personally consider and then discuss with their physician participation in trials, is needed. In the proposed research, we directly address the problem of low minority participation rates in clinical trials through a development of a decision aid (DA) for participation in clinical trials that is targeted to minority individuals. Decision aids (DAs) have been widely and successfully used in treatment and screening situations. A systematic review of DA trials has shown that patients receiving DAs have a higher knowledge of options and outcomes, more realistic expectations, less difficulty in reaching a decision, and more active participation in decision making than individuals who do not receive the DA. However, despite the fact that decision to participate in clinical trials is one of the most difficult and complex health care decisions for individuals, almost no previous work as been done on decision aid for clinical trials participation. We believe that participation in clinical trials, particularly for minorities, will be increased by the availability of a well-design, culturally sensitive decision aid. Thus, our goal for this research is to develop and test for effectiveness a minority targeted DA for participation in clinical trials. Specifically our aims are: Aim 1: Assemble a comprehensive database on attitudes, barriers and facilitators of participation in trials through integration of information from qualitative interviews with African American cancer survivors and/or family members, a systematic literature review, and a recently completed study of cancer clinical trials participation. Aim 2: Develop a targeted web-based decision aid in English and Spanish that has as its goals: a) providing information about clinical trials in a comprehensible way, b) improving patient self-efficacy for discussing trials with health care providers, and c) helping patients clarify their beliefs/values regarding the benefits and risks of participating in a trial. Aim 3: Explore the efficacy, usefulness, and effects of the decision aid a population of Hispanic and African American cancer survivors and family members. The proposed research will develop a targeted decision aid that aims to improve participation and particularly improve minority participation in a wide range of clinical trials. More efficient and representative recruitment means that clinical trials can accrue participants in a more timely fashion, and thus results about the effectiveness of new treatments and therapies can be obtained more efficiently. Thus, the proposed research will have a wide reaching effect on the clinical trials research community, and consequently on entire populations of patients who will benefit from the newly developed treatments and therapies.
描述(申请人提供):随机临床试验是评估医疗干预措施的金标准。然而,招募患者,特别是少数族裔,参加试验往往很困难。缓慢和不具代表性的试验累积延迟了新疗法的评估和引入,增加了成本,降低了试验的普适性。尽管越来越多的项目和网站正在提供有关临床试验的信息(两个例子是美国国立卫生研究院临床试验教育系列网站,以及美国国家医学会的I.M.P.A.C.T.项目(增加少数群体的参与和临床试验的意识)),但在提高少数群体的参与方面进展甚微。因此,我们认为,需要一种新的方法,以少数群体的具体关切和知识需求为目标,使他们能够亲自考虑,然后与他们的医生一起讨论参与试验的问题。在拟议的研究中,我们通过开发针对少数族裔个人的参与临床试验的决策辅助(DA)来直接解决少数族裔参与临床试验的问题。决策辅助(DA)已被广泛和成功地应用于治疗和筛查情况。对DA试验的系统回顾表明,与未接受DA的患者相比,接受DA的患者对各种选择和结果有更高的了解,更现实的期望,做出决定的难度更小,更积极地参与决策。然而,尽管参与临床试验的决策对于个人来说是最困难和最复杂的卫生保健决策之一,但几乎没有人像以前那样在参与临床试验的决策辅助方面做过工作。我们相信,通过提供设计良好、对文化敏感的决策辅助工具,将增加对临床试验的参与,特别是对少数族裔的参与。因此,我们这项研究的目标是开发和测试用于参与临床试验的少数人靶向DA的有效性。我们的具体目标是:目标1:通过整合对非裔美国人癌症幸存者和/或家庭成员的定性访谈、系统的文献综述和最近完成的癌症临床试验参与研究,建立一个关于参与试验的态度、障碍和促进者的全面数据库。目标2:开发基于英语和西班牙语的有针对性的网络决策辅助工具,其目标是:a)以可理解的方式提供有关临床试验的信息;b)提高患者与医疗保健提供者讨论试验的自我效能;c)帮助患者澄清他们对参与试验的益处和风险的信念/价值观。目的3:探索该决定的有效性、有用性和效果,以帮助拉美裔和非裔美国癌症幸存者及其家庭成员。这项拟议的研究将开发一种有针对性的决策辅助工具,旨在提高参与,特别是提高少数群体在广泛临床试验中的参与。更有效和更具代表性的招募意味着临床试验可以更及时地吸引参与者,从而可以更有效地获得关于新疗法和疗法有效性的结果。因此,拟议的研究将对临床试验研究界产生广泛的影响,从而对将从新开发的治疗和治疗中受益的整个患者群体产生广泛的影响。
项目成果
期刊论文数量(0)
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Margaret M Byrne其他文献
Margaret M Byrne的其他文献
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{{ truncateString('Margaret M Byrne', 18)}}的其他基金
A Stepped-care Psychosocial Intervention for Brain Tumor Family Caregivers
针对脑肿瘤家庭护理人员的阶梯式护理心理社会干预
- 批准号:
10417211 - 财政年份:2019
- 资助金额:
$ 84.16万 - 项目类别:
A Stepped-care Psychosocial Intervention for Brain Tumor Family Caregivers
针对脑肿瘤家庭护理人员的阶梯式护理心理社会干预
- 批准号:
10677018 - 财政年份:2019
- 资助金额:
$ 84.16万 - 项目类别:
A Stepped-care Psychosocial Intervention for Brain Tumor Family Caregivers
针对脑肿瘤家庭护理人员的阶梯式护理心理社会干预
- 批准号:
10199965 - 财政年份:2019
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Development and feasibility testing of a lung cancer screening decision aid
肺癌筛查决策辅助工具的开发和可行性测试
- 批准号:
8638579 - 财政年份:2014
- 资助金额:
$ 84.16万 - 项目类别:
Development and feasibility testing of a lung cancer screening decision aid
肺癌筛查决策辅助工具的开发和可行性测试
- 批准号:
8791650 - 财政年份:2014
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$ 84.16万 - 项目类别:
Development of a Conjoint Analysis Instrument for Lung Cancer Screening Decisions
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- 批准号:
8090509 - 财政年份:2010
- 资助金额:
$ 84.16万 - 项目类别:
Decision Making at the cutting edge of Environmental Health: Red Tides
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8046839 - 财政年份:2010
- 资助金额:
$ 84.16万 - 项目类别:
Decision Making at the cutting edge of Environmental Health: Red Tides
环境健康前沿决策:赤潮
- 批准号:
8147815 - 财政年份:2010
- 资助金额:
$ 84.16万 - 项目类别:
Development of a Conjoint Analysis Instrument for Lung Cancer Screening Decisions
肺癌筛查决策联合分析仪器的开发
- 批准号:
7991230 - 财政年份:2010
- 资助金额:
$ 84.16万 - 项目类别:
A Targeted Decision Aid to Improve Minority Participation in Clinical Trials
提高少数群体参与临床试验的有针对性的决策辅助工具
- 批准号:
7941896 - 财政年份:2009
- 资助金额:
$ 84.16万 - 项目类别:
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