Appetite Hormones in Binge Eating Disorder

暴食症中的食欲激素

• 批准号: 7831224
• 负责人: ALLAN GELIEBTER
• 金额: $ 73万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7831224
• 关键词: Abdomen; Amygdaloid structure; Anterior; Applications Grants; Area; Binge Eating; Binge eating disorder; Biological; Body fat; Brain; Brain imaging; Candy; Cell Nucleus; Consultations; Corpus striatum structure; Cues; Desire for food; Diagnosis; Distress; Eating; Eating Behavior; Eating Disorders; Emotional; Employment Opportunities; Enrollment; Epidemic; Food; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Hand; Height; Hippocampus (Brain); Hormones; Hunger; Ice; Individual; Ingestion; Insula of Reil; Intake; Laboratories; Lateral; Lead; Magnetic Resonance Imaging; Measures; Medial; Obesity; Outcome; Overweight; Participant; Posterior Hypothalamus; Prefrontal Cortex; Psychometrics; Recovery; Regulation; Relative (related person); Research; Resistance; Rewards; Running; Sampling; Satiation; Scanning; Screening procedure; Source; Specific qualifier value; Stimulus; Stress; Stress Tests; Testing; Time; United States National Institutes of Health; Videotape; Visual; Water; Weight; base; emotional eating; improved; outcome forecast; parent grant; psychologic; public health relevance; relating to nervous system; response; stressor; visual stimulus; waist circumference

DESCRIPTION (provided by applicant): This grant proposal is in response to NIH notice NOT-OD-09-058, 'NIH Announces the Availability of Recovery Acts Funds for Competing Revision.' The objective is to study the biological mechanisms regulating food intake under normal conditions and following a stressor in Binge Eating Disorder (BED). We plan to enroll 24 obese subjects (S's) with BED (12m, 12f), 24 obese S's without BED (12m, 12f) and 24 lean S's without BED (12m, 12f). At an initial consultation, S's will undergo recruitment screening and have height, weight, waist circumference, and body fat assessed. On a second day, they will have an abdominal MRI and a physical exam. As part of the parent grant, over two counterbalanced testing days (one in the morning and one in the afternoon), they will have appetite-related hormones measured before and after a test meal followed by a stress test, and multi-item ad libitum meal. The competitive revision component will expand on the appetite response to the stress component: On two additional separate days of testing, fMRI will be used to examine areas of brain activation in response to visual stimuli of high-palatability foods (HPF), compared with low-palatability foods (LPF), and non-foods (NF). On one of these days, the fMRI scan will be preceded by a Socially-Evaluated Cold Pressor Test (SECPT), a stress test in which the participant places one hand in a basin of ice water while being videotaped. On the other day, the scan will follow a control condition, in which the participant places a hand in a basin of warm water. The SECPT and control condition will both be conducted while the participant sits on the scanner table, just prior to scanning. Compared with obese nonBED S's, we expect the obese BED S's to show increased activation in areas associated with planned ingestion (e.g., ventral premotor cortex) and food reward (e.g., medial orbitofrontal cortex [OFC]), and, in the stress condition, increased activation in areas associated with food reward and poor emotional regulation (e.g., ventral amygdala, anterior cingulate). Compared with lean nonBED S's, we expect obese nonBED S's to show increased activation in areas associated with appetitive reward (e.g., medial and lateral OFC, insula, hippocampus, striatum), and decreased brain activation in areas associated with the inhibition of food intake and satiety (e.g., dorsolateral prefrontal cortex, posterior hypothalamus [i.e., ventromedial nucleus]). These differences among groups are expected to be present following the control condition but much more pronounced following the stressor. PUBLIC HEALTH RELEVANCE: The rising obesity epidemic makes it important to study the pathophysiology of Binge Eating Disorder (BED), which occurs in a significant subset of obese individuals. BED is arguably the most common eating disorder, a major source of distress for many overweight individuals, and may be associated with poorer prognosis and resistance to treatment. Currently, the biological substrates and mechanisms underlying BED, including the neural basis and the differences from obesity without BED, are poorly understood. We plan to use brain imaging to observe the brain's responses to visual food stimuli after a laboratory stressor in obese individuals with and without BED and in lean S's without BED. These findings may lead to improved diagnosis and treatment of BED and obesity.

描述（由申请人提供）：本拨款提案是对NIH通知no - od -09-058的回应，“NIH宣布恢复法案基金可用于竞争性修订。”目的是研究暴饮暴食症（BED）在正常情况下和应激源后调节食物摄入的生物学机制。我们计划招募24名肥胖者（S’S）伴有BED (12m, 12f)， 24名肥胖者（S’S）不伴有BED (12m, 12f)， 24名瘦人（S’S）不伴有BED （12m, 12f）。在初次咨询时，S将接受招募筛选，并评估身高、体重、腰围和体脂。第二天，他们将接受腹部核磁共振成像和身体检查。作为父母资助的一部分，在两个平衡的测试日（一个在上午，一个在下午）中，他们将在测试餐前后测量与食欲相关的激素，随后进行压力测试和多项目随意用餐。竞争修正部分将扩展食欲对压力部分的反应：在另外两天的测试中，fMRI将用于检查大脑对高口味食物（HPF）的视觉刺激反应的激活区域，与低口味食物（LPF）和非食物（NF）进行比较。在这些天中的某一天，fMRI扫描之前将进行社会评估冷压测试（SECPT），这是一项压力测试，参与者将一只手放在一盆冰水中，同时进行录像。另一天，扫描将遵循一个控制条件，在这个条件下，参与者将一只手放在一盆温水中。SECPT和控制条件都将在参与者坐在扫描桌上时进行，就在扫描之前。与肥胖的非BED S相比，我们预计肥胖的BED S在与计划进食相关的区域（如腹侧运动前皮层）和食物奖励相关的区域（如内侧眶额皮质[OFC]）中表现出增加的激活，并且，在应激条件下，与食物奖励和不良情绪调节相关的区域（如腹侧杏仁核，前扣带）的激活增加。与瘦的非bed S相比，我们预计肥胖的非bed S在与食欲奖励相关的区域（例如，内侧和外侧OFC，岛，海马，纹状体）中表现出更高的激活，而在与食物摄入和饱腹感相关的区域（例如，背外侧前额叶皮层，下丘脑后部[即腹内侧核]）中表现出更低的大脑激活。在控制条件下，各组之间的这些差异预计会出现，但在压力源下，这些差异会更加明显。