SPECT Imaging Module for Small Animal Imaging

用于小动物成像的 SPECT 成像模块

• 批准号: 7595572
• 负责人: VIBHUDUTTA AWASTHI
• 金额: $ 36.7万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-14 至 2010-05-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595572
• 关键词: Address; Animal Model; Animals; Area; Biodistribution; Biological Markers; Cadmium; Clinical; Clinical Drug Development; Complement; Critical Pathways; Detection; Development; Drops; Education; Goals; Health Sciences; Healthcare; Image; Laboratories; Mission; Modality; Molecular; Nature; Nuclear; Oklahoma; Orphan; Pharmacologic Substance; Pharmacy Education; Pharmacy facility; Phase; Photons; Positron-Emission Tomography; Publishing; Radioisotopes; Radiopharmaceuticals; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Services; Speed; System; Testing; Universities; X-Ray Computed Tomography; Zinc; base; college; detector; drug development; human disease; image reconstruction; improved; pre-clinical; programs; public health relevance; research facility; single photon emission computed tomography; tomography

DESCRIPTION (provided by applicant): Our long-term objective is to establish a small animal imaging facility (SAIF) at the College of Pharmacy in the University of Oklahoma Health Sciences Center (OUHSC). The purpose of this proposal is to acquire a single photon emission tomography (SPECT) system for small animals. The system will complement our existing capabilities of providing positron emission tomography (PET) and computed tomography (CT) for imaging animal models. We envision creating the SAIF infrastructure in order to distribute the expertise of nuclear imaging in growing drug development and pre-clinical efforts within the ranks of OUHSC, and other Oklahoma-based research centers and pharmaceutical laboratories. The acquisition of a SPECT system will facilitate the over all goal of the College of Pharmacy to expand nuclear pharmacy education, research and service. As such, the specific aims of this proposal are: 1. to acquire SPECT module for our existing small animal PET-CT system, and 2. to establish a mechanism for provision of imaging capabilities to the biomedical researchers. The College of Pharmacy has already acquired a PET-CT system for small animals. The system is modular in nature and has the capability of being upgraded to a tri-modality system by addition of a SPECT module. We propose to obtain a module based on advanced Cadmium Zinc Telluride detector with high energy, spatial, and contrast resolution. The proposed detector has high sensitivity of detection. The SPECT will be acquired with the imaging and reconstruction package which will enable us to simultaneously image multiple SPECT radionuclides within the same session. Significance: Recently, the FDA and NCI have published a Critical Path Initiative to address dropping submission rate of new molecular entities. The development of imaging biomarkers is an essential part of the strategy proposed to overcome this barrier. The proposed SAIF will be the first in Oklahoma region to provide multi-modality nuclear imaging. It will be leveraged by biomedical researchers in OUHSC as well as other research facilities in Oklahoma to hasten pre-clinical phase of drug development. With the ever increasing number of researchers seeking a variety of imaging support, acquisition of SPECT in OUHSC has become a necessity. The proposed SPECT system will also add essential value in the overall educational program of the College of Pharmacy which offers graduate program in nuclear pharmacy. In service area, the OUHSC Nuclear Pharmacy often produces `orphan' SPECT radiopharmaceuticals for clinical use. The existence of SPECT imaging within the College of Pharmacy will be of immense value in testing these products for their imaging potential and biodistribution before their clinical usage. Therefore, SPECT imaging in SAIF will serve all three components of the OUHSC mission- Research, Education and Service, and help OUHSC fulfill its ambition to improve regional health care. PUBLIC HEALTH RELEVANCE: We propose to acquire a single photon emission tomography (SPECT) system to image small animal models of human diseases. The SPECT will help speed up pre-clinical drug development research in Oklahoma region, supplement educational program in nuclear pharmacy, and provide a resource to the OUHSC Nuclear Pharmacy for the development of new radiopharmaceuticals.

描述（由申请人提供）：我们的长期目标是在俄克拉荷马州大学健康科学中心（OUHSC）的药学院建立一个小动物成像设施（SAIF）。本提案的目的是获得一个单光子发射断层扫描（SPECT）系统的小动物。该系统将补充我们现有的能力，提供正电子发射断层扫描（PET）和计算机断层扫描（CT）成像动物模型。我们设想创建SAIF基础设施，以便在OUHSC和其他俄克拉荷马州研究中心和制药实验室的队伍中，在不断增长的药物开发和临床前工作中分配核成像的专业知识。SPECT系统的收购将促进药学院的总体目标，以扩大核药学教育，研究和服务。因此，本建议的具体目标是：1.为我们现有的小动物PET-CT系统获取SPECT模块，以及2.建立向生物医学研究人员提供成像能力的机制。药学院已经为小动物购买了PET-CT系统。该系统本质上是模块化的，并且能够通过添加SPECT模块升级为三模态系统。我们建议获得一个模块的基础上先进的碲锌镉探测器具有高能量，空间和对比度分辨率。该检测器具有较高的检测灵敏度。SPECT将使用成像和重建包进行采集，这将使我们能够在同一会话中同时对多个SPECT放射性核素进行成像。重要性：最近，FDA和NCI发布了一项关键路径倡议，以解决新分子实体提交率下降的问题。成像生物标志物的发展是克服这一障碍的战略的重要组成部分。拟议的SAIF将是俄克拉荷马州地区第一个提供多模态核成像的机构。它将被OUHSC的生物医学研究人员以及俄克拉荷马州的其他研究机构利用，以加快药物开发的临床前阶段。随着越来越多的研究人员寻求各种成像支持，在OUHSC中获取SPECT已成为必要。拟议的SPECT系统也将增加药学院的整体教育计划，提供核药学研究生课程的基本价值。在服务区，OUHSC核药房经常生产“孤儿”SPECT放射性药物供临床使用。药学院内SPECT成像的存在将在临床使用前测试这些产品的成像潜力和生物分布方面具有巨大价值。因此，SAIF的SPECT成像将服务于OUHSC使命的所有三个组成部分-研究，教育和服务，并帮助OUHSC实现其改善区域卫生保健的雄心。 公共卫生相关性：我们建议获得一个单光子发射断层扫描（SPECT）系统，以成像人类疾病的小动物模型。SPECT将帮助加快俄克拉荷马州地区的临床前药物开发研究，补充核药学教育计划，并为OUHSC核药学提供开发新放射性药物的资源。

项目成果

Cyclodextrin-mediated entrapment of curcuminoid 4-[3,5-bis(2-chlorobenzylidene-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic acid] or CLEFMA in liposomes for treatment of xenograft lung tumor in rats.

• DOI: 10.1016/j.colsurfb.2011.01.023
• 发表时间: 2011-06-01
• 期刊: COLLOIDS AND SURFACES B-BIOINTERFACES
• 影响因子: 5.8
• 作者: Agashe, Hrushikesh;Sahoo, Kaustuv;Lagisetty, Pallavi;Awasthi, Vibhudutta
• 通讯作者: Awasthi, Vibhudutta

Evaluation of (99m)Tc-probestin SPECT as a novel technique for noninvasive imaging of kidney aminopeptidase N expression.

• DOI: 10.1021/mp5002872
• 发表时间: 2014-08-04
• 期刊: Molecular pharmaceutics
• 影响因子: 4.9
• 作者: Pathuri G;Madka V;Hedrick AF;Lightfoot SA;Awasthi V;Cowley BD Jr;Rao CV;Gali H
• 通讯作者: Gali H

Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo.

• DOI: 10.1021/bc200546b
• 发表时间: 2012-01-18
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Pathuri, Gopal;Hedrick, Andria F.;Disch, Bryan C.;Doan, John T.;Ihnat, Michael A.;Awasthi, Vibhudutta;Gali, Hariprasad
• 通讯作者: Gali, Hariprasad

Synthesis and in vivo evaluation of Tc-99m-labeled cyclic CisoDGRC peptide conjugates for targeting αvβ3 integrin expression.

用于靶向 αvβ3 整合素表达的 Tc-99m 标记的环状 CisoDGRC 肽缀合物的合成和体内评估。

• DOI: 10.1016/j.bmcl.2010.08.082
• 发表时间: 2010
• 期刊: Bioorganic & medicinal chemistry letters
• 影响因子: 2.7
• 作者: Pathuri,Gopal;Sahoo,Kaustuv;Awasthi,Vibhudutta;Gali,Hariprasad
• 通讯作者: Gali,Hariprasad