A 7 Tesla MRI Scanner for Small Animal Imaging Research

用于小动物成像研究的 7 特斯拉 MRI 扫描仪

• 批准号: 7497849
• 负责人: S. Ted Treves
• 金额: $ 197万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497849
• 关键词: Anatomy; Anesthesiology; Animal Model; Animals; Area; Arts; Basic Science; Biology; Blood Vessels; Boston; Brain Neoplasms; Cardiac Surgery procedures; Cardiology; Cell Nucleus; Cephalic; Cerebrum; Child; Communicable Diseases; Communities; Computer software; Data; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Ensure; Funding; Genetic; Grant; Hematology; Hypertrophy; Hypoxia; Image; Imaging Device; In Situ; Injury; Laboratories; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measures; Mission; Modeling; Myocardial; Myocardium; Neurobiology; Neurons; Orthopedics; Osteomalacia; Osteoporosis; Pathology; Pediatric Hospitals; Perfusion; Physiologic calcification; Radiology Specialty; Rattus; Research; Research Personnel; Resolution; Tuberous sclerosis protein complex; Ultrasonography; instrument; instrumentation; oncology; public health relevance; pup; soft tissue; tumor

DESCRIPTION (provided by applicant): High End Instrumentation Grant support is requested to fund the purchase of a state- of-the-art Bruker Biospec 7 Tesla, 20 cm, bore small animal MRI scanner and the associated hardware and software necessary to enhance, advance, and stimulate NIH-funded basic science research at Children's Hospital Boston (CHB). This instrument will comprise a new and critical component of SAIL, the Small Animal Imaging Laboratory at CHB. The addition of this instrument to the suite of small animal imaging instrumentation currently available in SAIL (microPET, microCT, and small animal ultrasound) will greatly expand the capabilities of the facility and allowing it to fulfill its mission of providing small animal imaging support to the basic science research community. This instrument will extend the capabilities of the CHB research mission by allowing researchers 1) to obtain high-contrast images of soft tissue to measure progression of orthotopic brain tumor models in situ; 2) to perform diffusion, perfusion, and flow imaging to examine the effects of anti-angiogenic and other therapies in tumor models and the degree of hypoxic/ischemic cerebral injury in rat pups; 3) to use magnetic resonance spectroscopy (MRS) to study cardiac muscle energetics in myocardial hypertrophy and bone mineralization in osteoporosis and osteomalacia and perform magnetic resonance spectroscopy (MRS) studies with 1H and 31P (and other) nuclei; and 4) to perform high spatial resolution diffusion tensor imaging (DTI) studies to determine the degree of miswiring of neuronal connections associated with tuberous sclerosis complex (TSC) and congenital cranial dysinnervation disorders (CCDDs) in animal models of these conditions. In many cases, these projects will utilize a combination of microPET and small animal MRI to obtain complementary functional and anatomic data. The research departments that will benefit from these new capabilities will include Vascular Biology, Cardiology, Cardiac Surgery, Neurobiology, Infectious Disease, Orthopedics, Pathology, Anesthesiology, Hematology/Oncology, and Radiology. PUBLIC HEALTH RELEVANCE: In the 20th century, research at CHB was instrumental in eradicating diseases that had, in many cases, threatened children for hundreds of years. Today, CHB researchers are again leading the way in research areas such as cancer, infectious disease, and genetics using state-of-the art small animal imaging tools (including the instrument requested here) to advance these fields. The deployment of a small animal MRI scanner at CHB will dramatically enhance small animal imaging capabilities at CHB, accelerating basic science research efforts, ensuring similarly spectacular progress well into the 21st century.

描述（由申请人提供）：申请高端仪器补助金支持，以资助购买最先进的Bruker Biospec 7 Tesla，20 cm，内径小动物MRI扫描仪以及相关硬件和软件，以增强，推进和刺激NIH资助的波士顿儿童医院（CHB）基础科学研究。该仪器将包括SAIL的一个新的关键组成部分，CHB的小动物成像实验室。将该仪器添加到SAIL目前可用的小动物成像仪器套件（microPET、microCT和小动物超声）中，将大大扩展该设施的能力，并使其能够履行其提供小动物成像的使命为基础科学研究界提供支持。该仪器将扩展CHB研究使命的能力，使研究人员能够：1）获得软组织的高对比度图像，以测量原位脑肿瘤模型的进展; 2）进行扩散、灌注和流动成像，以检查肿瘤模型中抗血管生成和其他治疗的效果以及大鼠幼崽缺氧/缺血性脑损伤的程度; 3）应用磁共振波谱（MRS）研究心肌肥厚和骨质疏松、骨软化症患者骨矿化时的心肌能量学，并进行~ 1H和~（31）P磁共振波谱（MRS）研究（和其他）核;进行高空间分辨率弥散张量成像（DTI）在这些疾病的动物模型中，研究确定与结节性硬化综合征（TSC）和先天性颅神经支配障碍（CCDD）相关的神经元连接的错误布线程度。在许多情况下，这些项目将利用microPET和小动物MRI的组合来获得互补的功能和解剖数据。受益于这些新功能的研究部门将包括血管生物学、心脏病学、心脏外科、神经生物学、传染病、骨科、病理学、麻醉学、血液学/肿瘤学和放射学。 公共卫生相关性：在20世纪，CHB的研究有助于根除在许多情况下威胁儿童数百年的疾病。今天，CHB研究人员再次在癌症，传染病和遗传学等研究领域领先，使用最先进的小动物成像工具（包括这里要求的仪器）来推进这些领域。在CHB部署小动物MRI扫描仪将大大提高CHB的小动物成像能力，加速基础科学研究工作，确保类似的壮观进展进入21世纪世纪。