Mechanisms and Functional Outcomes of Excercise Progression Models in the Ederly

老年运动进展模型的机制和功能结果

基本信息

批准号：
7820459
负责人：
Jason David Allen
金额：
$ 49.95万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7820459
关键词：
Accounting Activities of Daily Living Address Aerobic Exercise Age Age Reporting Aging American American Heart Association Area Baltimore Biological Availability Biopsy Blood Vessels Blood flow Body Composition Body Regions Cardiovascular system Clinical Research Data Disabled Persons Disease Elderly Ensure Excision Exercise Exercise stress test Frequencies Health Care Costs Health Expenditures Healthcare Individual Intervention Laboratories Life Longitudinal Studies Measures Metabolic Modeling Muscle Muscle Contraction Muscle function Nitric Oxide Orthopedics Oxygen Performance Peripheral Persons Physical Function Physical activity Physiologic pulse Physiological Population Probability Protocols documentation Qualifying Reporting Risk Roentgen Rays Site Skeletal Muscle Sports Medicine Stimulus Stress Testing Training Training Programs Work college disability early onset functional outcomes human old age (65+)mortality muscle form muscular structure novel prevent response strength training success

项目摘要

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic 04-AG-107: Mechanisms of specific benefits of different types of physical activity. MECHANISMS AND FUNCTIONAL OUTCOMES OF EXERCISE PROGRESSION MODELS IN THE ELDERLY By 2030, the number of Americans 65 years or older will account for roughly 20% of the US population, with a projected increase in the Nation's health care spending of 25%. A major factor in the projected increase in health care costs is the consequences of a progressive decline in functional capacity with advancing age. The decline in functional capacity can be slowed with the help of exercise training as recommended by the American College of Sports Medicine (ACSM) and American Heart Association (AHA). Unfortunately, improvements in functional capacity, in the elderly are rather small, in part, because many elderly cannot tolerate sufficiently high intensity exercise due to orthopedic and cardiovascular limitations. Thus, despite some success, existing training strategies, for the elderly, appear less than optimal. Therefore, the challenge for our rapidly aging nation is to define interventions, for the elderly that can slow the decline in functional capacity and performance, prevent early onset of physical disability and loss of independence. The potential impact is a reduction in the probability of disease, disability, early mortality, and health care expenditures. We hypothesize that regionally specific exercise stimuli, applied at the beginning of a training program, will serve as a physiological primer capable of removing peripheral barriers that limit functional capacity, in elderly at risk of losing independence. Removal of peripheral barriers early in a training program will unlock a greater potential for change in functional capacity. Subsequently, the objectives of this proposal are twofold: (1) To determine differences between 4 weeks of a regionally specific exercise stimulus or standard aerobic exercise training on physical and functional performance; and (2) To determine the effects of subsequent 8 weeks of progressive whole- body training protocol on the magnitude of change in physical and functional performance. Of particular importance to these objectives is the combination of physiological information from biospecimens (vascular and muscular) with functional outcomes in the elderly, following two different types of exercise training progression models. Statement of Relevance By 2030, 20% of the US population will be > 65 years old. Current training strategies for the elderly only show small effects on functional capacity. We will use a Regionally Specific Training Program to remove peripheral limitations and unlock a greater potential for change in functional capacity.

描述（由申请人提供）：此申请应解决广泛的挑战领域（04）：临床研究和特定挑战主题04-AG-107：不同类型的体育活动的特定益处的机制。到2030年，老年人的运动进展模型的机制和功能结果，65岁或以上的美国人数量将占美国人口的20％，预计该国医疗保健支出将增加25％。预计医疗保健成本增加的主要因素是随着年龄的增长，功能能力逐渐下降的后果。按照美国运动医学学院（ACSM）和美国心脏协会（AHA）建议的运动训练的帮助，功能能力的下降可以减慢。不幸的是，在老年人中，功能能力的提高部分相当小，部分原因是，由于骨科和心血管局限性，许多老年人无法忍受足够的高强度运动。因此，尽管有一些成功，但对于老年人来说，现有的培训策略似乎并不是最佳选择。因此，我们迅速衰老的国家面临的挑战是定义干预措施，因为老年人可以减缓功能能力和绩效的下降，防止身体残疾的早期发作和独立丧失。潜在的影响是减少疾病，残疾，早期死亡率和医疗保健支出的可能性。我们假设在培训计划开始时应用的区域特定的运动刺激将作为一种生理底漆，能够消除限制功能能力的外围屏障，以限制具有失去独立性的老年人。在培训计划的早期，清除外围屏障将释放更大的功能能力变化潜力。随后，该提案的目标是双重的：（1）确定针对身体和功能性能的区域特定运动刺激或标准有氧运动训练的4周之间的差异；（2）确定随后的8周进行全身训练方案对身体和功能性能变化的幅度的影响。对于这些目标，尤其重要的是，遵循两种不同类型的运动训练进展模型，从生物测量（血管和肌肉）中的生理信息与老年人的功能结果结合在一起。到2030年的相关性声明，美国20％的人口将> 65岁。当前的老年人培训策略仅对功能能力显示出很小的影响。我们将使用特定于区域的培训计划来消除外围限制，并解锁更大的功能能力变化潜力。