Role of TFII-I in Craniofacial Development

描述（由申请人提供）：本独立科学家奖（K 02）申请是基于申请人最近获得的NIDCR（DE 017205）2006-2010年NIH R 01奖。名为“TFII-I在颅面发育中的作用”的父母R 01奖解决了TFII-I转录因子在口面发育中的功能。与原始R 01申请中提出的研究相比，本K 02申请的“研究计划”部分中提出的拟议研究没有显著变化，除了此后取得的一些进展被纳入本申请的初步数据部分。原始R 01申请中提出的研究方法和实验设计主要基于申请人在小鼠遗传学和分子生物学方面的科学培训和专业知识。申请人充分认识到多学科在开展竞争性和高质量研究方面的重要性，这对成功的科学事业至关重要。因此，申请人计划获得额外的专业知识和学习新的系统，以将原提案提升到更高的水平和程度，主要研究者在功能筛选、蛋白质生物化学和蛋白质组学以及系统生物学方面的科学专业知识。详细情况和理由见候选人“职业发展计划”的下一节。

DESCRIPTION (provided by applicant): This Independent Scientist Award (K02) application is based on the applicant's recently funded NIH R01 award from NIDCR (DE 017205) for the years of 2006-2010. The parental R01 award entitled "Role of TFII-I in Craniofacial Development" addresses the function of the TFII-I transcription factor in orofacial development. The proposed research presented in the "Research Plan" section of this K02 application does not have significant changes compared with the studies proposed in the original R01 application, except that some progress made since then is incorporated in the preliminary data section of this application. The research approaches and experimental design proposed in the original R01 application are largely based on the applicant's scientific training and expertise in mouse genetics and molecular biology. The applicant fully realizes the importance of multi-discipline in conducting competitive and high quality research, which is essential for a successful scientific career. Therefore, the applicant plans to acquire additional expertise and learn new systems to promote the original proposal to a higher level and extent the principal investigator's scientific expertise in functional screening, protein biochemistry and proteomics, and systems biology. The details and rationale are described in the following section of the candidate's "career developmental plan".