Molecular Genetics Emphasizing Vision Research

强调视觉研究的分子遗传学

• 批准号: 7888300
• 负责人: Graeme Mardon
• 金额: $ 27.46万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7888300
• 关键词: Molecular Genetics; Vision research

DESCRIPTION (provided by applicant): This is a resubmission of a competing renewal application for continued support for a training grant in molecular genetics emphasizing vision research at Baylor College of Medicine. At the time of the last renewal, the program was awarded six pre- and two postdoctoral positions and we are requesting a continuation of the same number of slots. The goal of this proposal is to provide comprehensive training to predoctoral students and postdoctoral fellows in both molecular genetics and visual processes in preparation for careers in vision research. There are 17 training faculty, including Full, Associate, and Assistant Professors. These faculty maintain independent, well-funded laboratories conducting research in both genetics and visual processes. Major areas of research include the molecular genetics of human eye disease, studies of fundamental retinal processes using the mouse, zebrafish, and Drosophila as model organisms, phototransduction, cataract formation, lens and corneal development, and glaucoma. All faculty on this grant actively use genetic techniques to pursue vision research and represent three institutions at the Texas Medical Center. Indeed, the highly interactive, multi-departmental and inter-institutional composition of our faculty is a key strength of our program. Student training comprises a full year of didactic and interactive coursework, journal clubs, and research rotations. In addition, we continue to offer a course entitled "Molecular Genetics in Vision Research" as well as a bi-monthly research seminar series, the "Houston Eye Club," in which graduate students and postdoctoral fellows present their work to a group about 30-40 researchers from more than a dozen vision research laboratories in Houston. Students are expected to remain on this grant for 2-4 years while fellows will usually be supported for 1-2 years during which time they are expected to apply for extramural funding. Predoctoral fellows are also advised and encouraged to apply for predoctoral fellowships when possible. Currently, there are 320 graduate students and 151 postdoctoral fellows eligible for support in the departments associated with this training program. In the last 10 years, 11 graduate students supported by this training grant have received a Ph.D. degree and four of these have continued their careers in vision research. Of the five postdoctorals supported, four are still engaged in vision research. Since many visual system disorders are inherited and there have been recent and significant advances in applying gene therapy to treat retinal disease, training new scientists who are well versed in both genetics and vision research is a top priority of our training program.

描述（由申请人提供）：这是一个竞争性的续期申请的重新提交，以继续支持贝勒医学院的分子遗传学培训补助金，强调视觉研究。在最后一次更新时，该计划被授予六个前和两个博士后职位，我们要求继续相同数量的插槽。该提案的目标是为博士前学生和博士后研究员提供分子遗传学和视觉过程方面的全面培训，为视觉研究的职业生涯做准备。有17个培训教师，包括全职，副教授和助理教授。这些教师保持独立，资金充足的实验室进行遗传学和视觉过程的研究。主要研究领域包括人类眼病的分子遗传学，以小鼠、斑马鱼和果蝇为模式生物的基本视网膜过程研究，光传导，白内障形成，透镜和角膜发育，以及青光眼。该基金会的所有教职员工都积极使用遗传技术进行视力研究，并代表德克萨斯州医学中心的三个机构。事实上，我们教师的高度互动，多部门和机构间的组成是我们计划的关键优势。学生培训包括一整年的教学和互动课程，期刊俱乐部和研究轮换。此外，我们继续提供题为“视觉研究中的分子遗传学”的课程以及双月研究研讨会系列，“休斯顿眼科俱乐部”，其中研究生和博士后研究员向来自休斯顿十几个视觉研究实验室的约30-40名研究人员介绍他们的工作。学生预计将继续在这个补助金为2-4年，而研究员通常将支持1-2年，在此期间，他们预计将申请校外资助。还建议并鼓励博士前研究员在可能的情况下申请博士前研究金。目前，有320名研究生和151名博士后研究员有资格在与该培训计划相关的部门获得支持。在过去10年中，有11名研究生获得了博士学位。学位，其中四人继续他们的职业生涯在视觉研究。在获得资助的五名博士后中，有四名仍在从事视觉研究。由于许多视觉系统疾病是遗传性的，并且最近在应用基因疗法治疗视网膜疾病方面取得了重大进展，因此培养精通遗传学和视觉研究的新科学家是我们培训计划的首要任务。