CYCLOPHOSPHAMIDE AND TASTE

环磷酰胺和味道

• 批准号: 8168176
• 负责人: Eugene R Delay
• 金额: $ 3.84万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168176
• 关键词: Adult; Adverse effects; Area; Behavioral; Cell Cycle; Cell physiology; Cells; Computer Retrieval of Information on Scientific Projects Database; Cyclophosphamide; DNA Damage; DNA Repair; Drug usage; Esthesia; Funding; Gene Family; Grant; Institution; Lead; Malnutrition; Methods; Molecular; Molecular Biology; Pharmaceutical Preparations; Recovery; Research; Research Personnel; Resources; Role; Sensory; Source; Stem cells; System; Taste Perception; Techniques; Testing; United States National Institutes of Health; Work; chemotherapy; interest; mouse model; repaired; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cyclophosphamide is the most commonly prescribed drug used for chemotherapy, but it like other chemotherapy drugs, has many adverse side effects such as altered or lost taste sensory abilities which can lead to malnutrition and poorer recovery. We are interested in what causes the changes in taste functions due to chemotherapy. We hypothesize that cyclophosphamide damages the DNA of stem cells or progenitor cells for new taste sensory cells. The cell cycle is arrested until the DNA repair is complete. Once repaired, new taste sensory cells are generated from the stem cells and taste sensations recover. To test this hypothesis, we propose four Specific Aims that will use a range of tools from behavioral techniques to molecular biology using a mouse model. We will use behavioral and molecular methods to assess the breadth of functional disruptions caused by cyclophosphamide. In addition we propose to study how the drug disrupts adult taste stem cell functioning and how the system recovers, including the role of the Sox family of genes. No previous work has been done in this area. Our work aims to fill some voids in the understanding of this often devastating side effect of chemotherapy.

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