THE ORGANIZATION OF POSTERIOR PARIETAL CORTICAL AREAS INVOLVED IN DEXTEROUS BEHA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 顶后皮质区域对所有哺乳动物，包括人类，在其环境中导航和操纵物体都是重要的。我们建议对大鼠的后顶叶皮质进行特征描述和比较，以便以后与其他哺乳动物物种(如负鼠、松鼠、雪貂和浣熊)进行比较，这些物种都有与特定用途相关的不同的前肢形态。本研究的目的是：1)用电生理学技术确定大鼠位于躯体感觉和视觉区域之间的顶叶后皮质的功能组织；2)用神经解剖示踪剂结合构筑技术确定这些区域皮质和丘脑皮质联系的完整范围。 我们在老鼠身上的结果将与理解其他物种的组织有关，因为所有哺乳动物大脑的组织都受到发育限制的严格控制。详细了解这些大脑区域在哺乳动物物种中是如何组织的，将使我们能够更好地理解人类体内这些管理与周围物体互动的重要大脑区域是如何组织的。这些研究将为进一步涉及实验性损伤的行为研究奠定基础，这将为直接与中风或创伤性脑损伤的受害者进行比较提供有用的数据。 这项拟议的研究将允许学生在中央阿肯色大学和国家毒理学研究中心的神经生物学实验室学习；并将在我的主要本科生机构和INBRE框架内的一个联邦实验室之间建立合作，从而为在代表性不足的机构中促进杰出生物医学研究的关键目标做出贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regions of posterior parietal cortex are important in all mammals, including humans, for navigating through, and manipulating objects in, their environment. We propose to characterize and compare the posterior parietal cortex of rats for later comparison with other mammalian species (e.g., opossum, squirrel, ferret, and raccoon), each of which has distinct forelimb morphology related to specific use. The aims of this study are 1) to determine the functional organization of posterior parietal cortex located between somatosensory and visual regions in rats using electrophysiological techniques, and 2) to determine the full extent of corticocortical and thalamocortical connections of these areas using neuroanatomical tracers combined with architectonic techniques. Our results in rats will be relevant to understanding the organization of other species because the organization of all mammalian brains is tightly governed by developmental constraints. A detailed understanding of how these brains areas are organized across mammalian species will allow us to better understand how these important brains regions that govern interactions with objects in the surroundings may be organized in humans. These studies will lay the groundwork for further behavioral studies involving experimental lesions, which will provide useful data for direct comparison to victims of stroke or traumatic brain injury. The proposed research will allow students to study in neurobiology laboratories at both the University of Central Arkansas and the National Center for Toxicological Research; and will establish collaborations between my primarily undergraduate institution and a federal laboratory, within the umbrella of INBRE, thus contributing to the crucial objective of promoting exceptional biomedical research in underrepresented institutions.