Human Adoptive Transfer Core

人类收养转移核心

• 批准号: 7917918
• 负责人: Jakub Tolar
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7917918
• 关键词: Adoptive Transfer; Cell Transplantation; Cells; Clinical; Clinical Trials; Clinical Trials Design; Data; Future; Genes; Goals; Hematopoietic; Hematopoietic stem cells; Human; Immune; Immunodeficient Mouse; Knowledge; Modeling; Mus; Natural Killer Cells; Principal Investigator; Recovery; Regulatory T-Lymphocyte; Research Personnel; Resource Sharing; Stem cells; T cell response; Testing; Umbilical Cord Blood; Umbilical Cord Blood Transplantation; Xenograft procedure; design; in vivo; leukemia; peripheral blood; pre-clinical; progenitor; programs; research study; response; stem cell biology; thymocyte

The aim of this core is to use a xenotransplantation murine model to provide in vivo readouts for experiments proposed in this program project. Specifically, this model will be used for the following purposes: 1. To optimize proliferation and function of T regulatory cells (Treg) for suppression of alloreactive responses. 2. To perform studies testing the hypothesis that human thymocyte progenitor cells (Tprog) will accelerate human thymopoiesis and peripheral blood T cell responses in immunodeficient mice. 3. To optimize proliferation and function of natural killer (NK) cells for leukemia therapy. These data will in turn inform the design of future clinical trials. The core leader will provide valuable knowledge of the stem cell biology, gene manipulations, murine models, and clinical hematopoietic cell transplantation, all relevant to this application. Core D is unique in its capability to allow two of the three Principal Investigators (who do not have access to preclinical murine models; Project 1 and 3) with a critical shared resource to enhance their scientific program.

本核心的目的是使用异种移植小鼠模型为本项目中提出的实验提供体内读数。具体来说，该模型将用于以下目的：