Baylor Intellectual and Developmental Disabilities Research Center

贝勒智力与发育障碍研究中心

• 批准号: 7931284
• 负责人: HUDA Y ZOGHBI
• 金额: $ 39.99万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931284
• 关键词: Baylor; Intellectual; Developmental; Disabilities; Research

DESCRIPTION (provided by applicant): The Baylor College of Medicine (BCM) Intellectual and Developmental Disabilities Research Center (IDDRC) was established on August 1, 1988 and has been continuously funded with the last renewal of funding dated July 1, 2004. The specific objectives are: 1) To enhance intellectual disabilities activities at BCM by encouraging and focusing research efforts on etiology, diagnosis, prevention, pathogenesis, and intervention of IDD. 2) To continue to promote a multidisciplinary approach to IDD research by improving interactions among Center investigators, and by continuing to develop and to apply leading edge technologies. 3) To enhance the productivity of project investigators through effective and efficient research core units and to facilitate translational research efforts. 4) To recruit new investigators into the field of IDD research through scientific interactions with center investigators and by providing the infrastructure for a multidisciplinary approach through the BCM-IDDRC Cores. 5) To promote scientific and collaborative interactions with investigators outside Baylor who have demonstrated a major commitment to study and treat IDD. The research projects will be supported by the Administrative Core (A), and by seven research cores: High Throughput Genomic & RNA Analysis (B), Genome-Wide RNAi Analysis (C), Gene Expression Analysis which includes Neuropathology, Confocal, and RNA in situ (D), Tissue Culture (E), Stem Cell (F), Mouse Neurobehavior (G), and Mouse Physiology (H). There are 48 faculty participants, including 41 research project investigators and 73 research projects. The scope of research at the BCM-IDDRC will include the following ten topic areas: 1) Neurobiology, cellular & molecular aspects of brain development; 2) Inborn errors of metabolism; 3) Genetic & epigenetic basis of diseases; 4) Innovative technologies for diagnosis & screening IDD; 5) Animal models for pathogenesis & for developing and testing therapeutics; 6) Pathways that affect function of nervous system; 7) Molecular, behavioral & therapeutic studies in IDD including fragile X, Angelman, Prader-Willi, and Rett syndromes; 8) Definition of clinical phenotypes in genetically diagnosed populations; 9) Studies of aggression, social behavioral problems and stereotypies; and 10) Neurobiology, genetics, pathogenesis & pharmacological approaches in autism spectrum disorders. PUBLIC HEALTH RELEVANCE: The overall goals of the Baylor IDDRC are to identify as many causes of intellectual and developmental disabilities as possible, to prevent these disorders, and to provide interventional schemes that can improve the quality of life of afflicted individuals and ameliorate their disability whenever possible.

DESCRIPTION (provided by applicant): The Baylor College of Medicine (BCM) Intellectual and Developmental Disabilities Research Center (IDDRC) was established on August 1, 1988 and has been continuously funded with the last renewal of funding dated July 1, 2004. The specific objectives are: 1) To enhance intellectual disabilities activities at BCM by encouraging and focusing research efforts on etiology, diagnosis, prevention, pathogenesis, and intervention of IDD。 2）通过改善中心研究人员之间的互动，并继续开发和应用前沿技术，继续促进多学科研究的多学科方法。 3）通过有效，有效的研究核心单位来提高项目研究人员的生产率，并促进转化研究工作。 4）通过与中心研究人员的科学互动，并通过BCM-IDDRC核心为多学科方法提供基础设施，从而招募新的研究人员进入IDD研究领域。 5）促进与贝勒以外的研究人员进行科学和协作互动，这些调查员表现出了对IDD进行研究和治疗的主要承诺。 研究项目将得到行政核心（a）的支持，并由七个研究核心：高吞吐量基因组和RNA分析（B），全基因组全基因组RNAI分析（C），基因表达分析，包括神经病理学，共焦和rna intu（d），d），组织培养（E），组织细胞（E），干细胞（f），小鼠Neurobeebeior（g），HAVER（HAV）（HAV）（HAV）（HAV）和HAR）（HHAV）和HAR）（HAV）和HAR）（HHII）（HAR）和HAR。 有48位教职员工，包括41名研究项目研究人员和73个研究项目。 BCM-IDDRC的研究范围将包括以下十个主题领域：1）脑发育的神经生物学，细胞和分子方面； 2）天生的新陈代谢错误； 3）疾病的遗传和表观遗传基础； 4）用于诊断和筛查IDD的创新技术； 5）用于发病机理和开发和测试治疗剂的动物模型； 6）影响神经系统功能的途径； 7）IDD中的分子，行为和治疗研究，包括脆弱的X，Angelman，Prader-Willi和Rett综合征； 8）遗传诊断人群中临床表型的定义； 9）研究侵略性，社会行为问题和刻板印象； 10）自闭症谱系障碍中的神经生物学，遗传学，发病机理和药理学方法。 公共卫生相关性：Baylor IDDRC的总体目标是确定尽可能多的智力和发育障碍原因，以防止这些疾病，并提供介入的计划，以改善患病个人的生活质量并尽可能改善残疾。