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中文摘要
翻译
行政核心支持尤尼斯肯尼迪施莱佛知识和发展的使命 贝勒医学院残疾人研究中心(CAIDDRC),以确定尽可能多的IDD的原因, 可能,了解其发病机制,并开发新的诊断和治疗方法, 监督和管理整个中心的活动,传播有关信息, 与IDDRC网络的研究人员以及 世界Huda Zoghbi博士担任中心主任已超过25年,大卫博士加入中心 纳尔逊和罗德尼·萨马科组成行政核心的执行团队。执行团队是 致力于确保该中心成为最具创新性和效率的中心。的首要目标 行政核心是通过鼓励和促进当地和 合作研究工作,开发治疗IDD的疗法,吸引和培训研究人员, 加强缺碘症研究和通过参与、交流和 利益相关者的教育。该核心将通过提供战略性的 核心设施,并随着油田的发展开发新的核心服务。所有的研究项目都是 使用行政核心。此核心有助于使核心服务与中心的总体使命保持一致, 与核心主任一起监测和确保所提供的服务是高质量和具有成本效益的, 确保核心服务充分利用现有资源和联合国系统的机构支持。芯会 通过临床翻译核心,支持IDD的翻译工作,旨在协助研究者 设计和开展人体研究,包括IRB批准,生物标本的获取,诊断 为缺碘症患者开展的研究和治疗干预以及一个多学科的标志性研究项目 这将导致临床试验准备就绪,开发出对改变的基因剂量具有特异性和敏感性的生物标志物。在 为了促进和加强合作努力和知识传播,核心建议 参与、交流和教育计划(ECE),扩大中心活动的范围 地方、州和国家层面的利益相关者。欧洲经委会将为社区实施最佳做法 建立和扩大现有的社区关系,以确保持续的双向合作 沟通,告知研究者和社区每个小组的问题/关注点,确保成功 招募和保留研究参与者,并确定未来在该人群中进行研究的可行性。的 行政核心认识到广泛合作的重要性,特别是与非洲减灾中心网络的合作, 将继续为所有网络活动作出贡献并与之合作。
英文摘要
The Administrative Core supports the mission of the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Baylor College of Medicine (BCM IDDRC) to identify as many causes of IDD as possible, to understand their pathogenesis, and to develop novel diagnostic and therapeutic approaches by providing oversight and management of the activities of the entire Center, disseminating information about advancements and coordinating collaborative efforts with researchers in the IDDRC network and around the world. Dr. Huda Zoghbi has served as the Center Director for more than 25 years and is joined by Drs. David Nelson and Rodney Samaco to form the Executive Team of the Administrative Core. The Executive Team is dedicated to ensuring that the BCM IDDRC is a most innovative and efficient Center. The overarching goal of the Administrative Core is to enhance IDD research activities at BCM by encouraging and fostering local and collaborative research efforts, the development of therapies to treat IDD, attracting and training investigators to enhance the workforce in IDD research and disseminating information through engagement, communication and education of stakeholders. This Core will support faculty research into IDD through provision of strategic core facilities and by developing new core services as fields advance. All research projects are proposed for use of the Administrative Core. This Core helps align core services to the overall mission of the Center, works with the Core Directors to monitor and ensure that the services provided are high-quality and cost-effective, and ensures that the Core services capitalize on existing resources and institutional support from BCM. The core will also support translational efforts in IDD through the Clinical Translational Core, designed to assist investigators with designing and carrying out human research including IRB approval, acquisition of biospecimens, diagnostic studies, and therapeutic interventions for people with IDD and a multidisciplinary signature research project that will lead to clinical trial readiness, developing biomarkers specific and sensitive to altered gene dosage. In order to promote and enhance collaborative efforts and dissemination of knowledge, the Core proposes a plan for engagement, communication, and education (ECE), extending the reach of the Center’s activities to stakeholders at the local, state, and national levels. The ECE will implement best practices for community partnerships building on and extending existing community relationships to ensure ongoing bi-directional communication, inform investigators and the community of questions/concerns by each group, ensure successful recruitment and retention of study participants, and determine feasibility of future studies in this population. The Administrative Core recognizes the importance of broad collaborations, especially with the IDDRC network and will continue to contribute to and collaborate with all network activities.
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ADMINISTRATIVE CORE
  • 批准号:
    10675457
  • 项目类别:
  • 资助金额:
    $17.65万
  • 财政年份:
    2020
  • 负责人:
    HUDA Y ZOGHBI
  • 依托单位:
ADMINISTRATIVE CORE
  • 批准号:
    10221023
  • 项目类别:
  • 资助金额:
    $17.65万
  • 财政年份:
    2020
  • 负责人:
    HUDA Y ZOGHBI
  • 依托单位:
CORE D1: Neuropathology
  • 批准号:
    8318647
  • 项目类别:
  • 资助金额:
    $29.0万
  • 财政年份:
    2011
  • 负责人:
    HUDA Y ZOGHBI
  • 依托单位:
NRI Build-out: Advancing Translational Brain Research
  • 批准号:
    7875553
  • 项目类别:
  • 资助金额:
    $1489.53万
  • 财政年份:
    2010
  • 负责人:
    HUDA Y ZOGHBI
  • 依托单位:
国内基金
海外基金
分化肌细胞脱细胞ECM-cells sheet 3D 支架构建及其促进容积性肌组织缺损再 生修复应用及机制研究
CAFs-TAMs-tumor cells调控在HRHPV感染致癌中的作用机制研究及AI可追溯预测模型建立
  • 批准号:
    82072862
  • 项目类别:
    面上项目
  • 资助金额:
    56.0万元
  • 批准年份:
    2020
  • 负责人:
    徐云升
  • 依托单位:
S100A8/A9--Myeloid cells特异性可溶性表氧化物水解酶(sEH)基因敲除改善胰岛素抵抗的新靶点
  • 批准号:
    82070825
  • 项目类别:
    面上项目
  • 资助金额:
    53.0万元
  • 批准年份:
    2020
  • 负责人:
    徐西振
  • 依托单位:
Leader cells通过CCL5调控糖酵解及基质硬度促进结直肠癌集体侵袭的 作用机制
  • 批准号:
    81903002
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.5万元
  • 批准年份:
    2019
  • 负责人:
    王斐斐
  • 依托单位: