Delaware INBRE

特拉华州INBRE

• 批准号: 7907291
• 负责人: KARL V. STEINER
• 金额: $ 97.98万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-29 至 2012-08-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907291
• 关键词: Delaware; INBRE

DESCRIPTION (provided by applicant): The goal of the Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the work of the current INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the lead and partner institutions. Three research themes will be pursued. A cancer program, begun under the current INBRE, will focus on cancer cell mobility, the role of specific proteins in metastasis, DNA repair and biomaterials for use in cancer treatments. A new cardiovascular program will focus on extra-cellular matrix remodeling in heart failure and biomaterials for cardiac tissue engineering. A new neuroscience program will address molecular mechanisms of learning and memory, spinal muscular atrophy and cardiovascular autonomic nerve function in diabetes. Funds to support junior faculty, postdoctoral and graduate students engaged in the research projects within each research theme, are provided. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Undergraduate Research and Professional Development Core will provide research opportunities for students from the State's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the technical knowledge of the State's workforce. PUBLIC HEALTH RELEVANCE (provided by applicant): The Delaware INBRE is focused on research in cancer, heart disease and neuroscience, three areas where disease take the lives of millions of Americans each year. The project helps promising scientists to begin their research careers/by providing research seed grants, which form a foundation for future research. Delaware INBRE also helps to build a new generation of health researchers, by involving undergraduate

描述（由申请人提供）：特拉华州INBRE更新提案的目标是通过扩展当前INBRE在建立全州生物医学研究能力方面的工作，向改善该州医疗保健迈出又一重大步骤。该项目将继续加强牵头机构和伙伴机构的研究专门知识和基础设施。将研究三个研究主题。在目前的INBRE下开始的一个癌症项目将侧重于癌细胞的流动性、特定蛋白质在转移中的作用、DNA修复和用于癌症治疗的生物材料。一个新的心血管项目将专注于心力衰竭的细胞外基质重塑和心脏组织工程的生物材料。一个新的神经科学计划将解决学习和记忆的分子机制，脊髓性肌萎缩症和糖尿病心血管自主神经功能。提供资金，以支持初级教师，博士后和研究生从事每个研究主题内的研究项目。研究主题得到了在当前INBRE下开发的全州生物医学基础设施的支持，但具有显著增强的生物信息学和集中仪器核心。本科生研究和专业发展核心将为来自国家本科院校和社区学院的学生提供研究机会，从而培养一批在医疗保健行业从事职业的学生，并提高国家劳动力的技术知识。 公共卫生相关性（由申请人提供）：特拉华州INBRE专注于癌症、心脏病和神经科学的研究，这三个领域的疾病每年夺走数百万美国人的生命。该项目通过提供研究种子赠款，帮助有前途的科学家开始他们的研究生涯，为未来的研究奠定基础。特拉华州INBRE还通过让本科生参与进来，帮助培养新一代的健康研究人员。