INBRE: UNIVERSITY OF DELAWARE: ADMINISTRATIVE CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。特拉华州INBRE 2006年度进展报告(APR)，批准号2P20RR016472-2006行政核心报告核心目标：行政核心在全州范围内领导和协调合作机构之间的计划活动。戴维·S·韦尔博士、INBRE Pi博士和INBRE行政主任卡尔·V·施泰纳博士，他们也是特拉华州生物技术研究所(DBI)的主任和副主任，领导特拉华州INBRE行政核心。行政核心在第二年的成就包括：1)从布林的基础设施建设重点过渡到INBRE的研究重点，并在特拉华大学(UD)、特拉华州立大学、克里斯蒂娜保健保健系统的海伦·F·格雷厄姆癌症中心和内穆斯儿童医院完成了第二年的有指导的生物医学研究项目。继续在参与机构之间发展健康、建设性的平等伙伴关系。2)参与组建了转化型癌症研究中心，作为在特拉华州发展医学研究能力倡议的一部分，参与的有生物医学研究所和加州大学内穆斯儿童医院的生物科学系，以及州最大的医疗保健提供者克里斯蒂娜护理中心的海伦·F·格雷厄姆癌症中心。特拉华州INBRE的教职员工正在领导一个由科学家和医生组成的翻译研究工作组，该工作组现在每隔六个月开会一次，研究癌症翻译研究的最新情况。该小组现在包括特拉华州的研究人员以及来自费城S坎摩尔癌症中心(杰斐逊医学院)和福克斯大通癌症中心的地区研究人员。目前正在进行谈判，以将心血管领域的翻译研究纳入其中。目前正在与特拉华州托马斯·杰斐逊大学S医学院进行平行谈判，为医学生和医生开发基于虚拟现实的教育和培训计划。3)征集了第二轮INBRE研究提案，更有针对性地侧重于癌症的基础研究和翻译研究。研究委员会和外部咨询委员会批准了2006年6月开始的13个新项目。4)制定了一个实质性的评估程序，包括由美国教育协会每两年进行一次实地考察，由特拉华大学教育研究和发展中心进行一次内部评估，并定期向特拉华州INBRE外部咨询委员会通报情况。正在开发一个在线用户界面和评价数据库。评价过程的初步结果导致重新分配来自不良方案的资金。5)继续发展仪器岩芯的能力和评价其有效性。例如，由INBRE/Cobre共同资助的生物信息学基础设施支持了特拉华大学在小RNA方面的开创性工作。微阵列已经被淡化，并被整合到一个包含微阵列、测序和蛋白质生产的多用途核心中。6)影响了UD护理学院研究作用的增加，学生参与了教师的研究项目，并推出了一门新课程，NURS362，护理研究概念。(7)继续在特拉华大学化学和生物化学/化学工程的新的双列课程的试点阶段。这门名为生物化学和生物技术实验室的课程旨在培养具有参与生物、生物化学、化学和化学工程研究所需的实验室技能的本科生。8)通过暑期本科生实习计划，让23名本科生参与与生物医学相关的研究项目。重点继续涉及一个不同的学生群体。2005年的小组包括60%的女性和30%的代表不足的学生，并涉及特拉华州INBRE所有合作机构的30多名教职员工。9)为INBRE参与者成功实施计划目标提供指导和领导。确保所有六个INBRE核心的计划目标都达到了。协调和监督财务和项目管理。10)为国家卫生研究院提供给特拉华州的资金增加作出了贡献--从2000年的1,490万美元增加到2005年的2,650万美元。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Administrative Core Report Core Objective: The Administrative Core provides statewide leadership and coordination of the program activities among the partner institutions. Dr. David S. Weir, INBRE PI and Dr. Karl V. Steiner, INBRE Administrative Director, who are also Director and Associate Director of the Delaware Biotechnology Institute (DBI), lead the Delaware INBRE Administrative Core. Accomplishments of the Administrative Core in Year 2 include: 1) Transitioned from the infrastructure-building focus of BRIN to a research focus in INBRE, and completed a second year of mentored biomedical research projects at the University of Delaware (UD), Delaware State University, the Helen F. Graham Cancer Center of Christiana Care Health Systems and Nemours Hospital for Children. Continued to develop a healthy, constructive partnership of equals among the participating institutions. 2) Participated in the formation of a Center for Translational Cancer Research as part of an initiative to develop a medical research capability in Delaware, involving DBI and the Department of Biological Sciences at UD, Nemours Hospital for Children, and the Helen F. Graham Cancer Center at Christiana Care, the State¿s largest health care provider. Delaware INBRE faculty are leading a translational research working group of scientists and physicians which now meets at six-month intervals for research updates on translational research in cancer. The group now includes Delaware researchers as well as regional researchers, from Philadelphia¿s Kimmel Cancer Center (Jefferson Medical College) and Fox Chase Cancer Center. Negotiations are underway to include translational research in the cardiovascular area. Parallel negotiations are underway with Thomas Jefferson University, Delaware¿s medical school, to develop virtual-reality based education and training programs for medical students and physicians. 3) Solicited a second round of INBRE research proposals, with a more targeted focus on basic and translational research in cancer. The Research Committee and the External Advisory Board have approved thirteen new projects that begin in June 2006. 4) Developed a substantial evaluation process involving a bi-annual site visit by AAAS, an internal evaluation process conducted by the University of Delaware Education Research and Development Center, and regular briefings to the Delaware INBRE External Advisory Board. Development of an online user interface and evaluation database is underway. Initial output of the evaluation process has resulted in reallocation of funding from a non-performing program. 5) Continued to develop the capability and evaluate effectiveness of instrumentation cores. For example, bioinformatics infrastructure funded jointly by INBRE/COBRE has supported groundbreaking work in small RNAs at the University of Delaware. Microarray has been de-emphasized, and has been incorporated into a multipurpose core containing microarray, sequencing and protein production. 6) Influenced an increase in the role of research in the UD School of Nursing, with students involved in faculty research projects, and the launch of a new course, NURS362, Research Concepts in Nursing. 7) Continued the pilot phase of a new double-listed course at the University of Delaware, Chemistry and Biochemistry/Chemical Engineering 467. The course, entitled Biochemistry and Biotechnology Laboratory is aimed at preparing undergraduates with laboratory skills necessary to participate in research in biology, biochemistry, chemistry, and chemical engineering. 8) Involved a cohort of 23 undergraduates in biomedically-relevant research projects through the summer undergraduate internship program. Emphasis continues to involve a diverse student group. The 2005 group included 60% women and 30% underrepresented students, and involved more than 30 faculty members at all Delaware INBRE partner institutions. 9) Provided guidance and leadership to the INBRE participants toward successful implementation of program goals. Assured that program objectives of all six INBRE Cores are met. Coordinated and oversaw financial and program management. 10) Contributed to the increase in NIH funding to the State of Delaware - from $14.9 Million in 2000 to $26.5 Million in 2005.