INBRE: UNIVERSITY OF DELAWARE: ADMINISTRATIVE CORE

INBRE：特拉华大学：行政核心

• 批准号: 7381583
• 负责人: DAVID S WEIR
• 金额: $ 25.36万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381583
• 关键词: INBRE; UNIVERSITY; DELAWARE; ADMINISTRATIVE; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Administrative Core Report Core Objective: The Administrative Core provides statewide leadership and coordination of the program activities among the partner institutions. Dr. David S. Weir, INBRE PI and Dr. Karl V. Steiner, INBRE Administrative Director, who are also Director and Associate Director of the Delaware Biotechnology Institute (DBI), lead the Delaware INBRE Administrative Core. Accomplishments of the Administrative Core in Year 2 include: 1) Transitioned from the infrastructure-building focus of BRIN to a research focus in INBRE, and completed a second year of mentored biomedical research projects at the University of Delaware (UD), Delaware State University, the Helen F. Graham Cancer Center of Christiana Care Health Systems and Nemours Hospital for Children. Continued to develop a healthy, constructive partnership of equals among the participating institutions. 2) Participated in the formation of a Center for Translational Cancer Research as part of an initiative to develop a medical research capability in Delaware, involving DBI and the Department of Biological Sciences at UD, Nemours Hospital for Children, and the Helen F. Graham Cancer Center at Christiana Care, the State¿s largest health care provider. Delaware INBRE faculty are leading a translational research working group of scientists and physicians which now meets at six-month intervals for research updates on translational research in cancer. The group now includes Delaware researchers as well as regional researchers, from Philadelphia¿s Kimmel Cancer Center (Jefferson Medical College) and Fox Chase Cancer Center. Negotiations are underway to include translational research in the cardiovascular area. Parallel negotiations are underway with Thomas Jefferson University, Delaware¿s medical school, to develop virtual-reality based education and training programs for medical students and physicians. 3) Solicited a second round of INBRE research proposals, with a more targeted focus on basic and translational research in cancer. The Research Committee and the External Advisory Board have approved thirteen new projects that begin in June 2006. 4) Developed a substantial evaluation process involving a bi-annual site visit by AAAS, an internal evaluation process conducted by the University of Delaware Education Research and Development Center, and regular briefings to the Delaware INBRE External Advisory Board. Development of an online user interface and evaluation database is underway. Initial output of the evaluation process has resulted in reallocation of funding from a non-performing program. 5) Continued to develop the capability and evaluate effectiveness of instrumentation cores. For example, bioinformatics infrastructure funded jointly by INBRE/COBRE has supported groundbreaking work in small RNAs at the University of Delaware. Microarray has been de-emphasized, and has been incorporated into a multipurpose core containing microarray, sequencing and protein production. 6) Influenced an increase in the role of research in the UD School of Nursing, with students involved in faculty research projects, and the launch of a new course, NURS362, Research Concepts in Nursing. 7) Continued the pilot phase of a new double-listed course at the University of Delaware, Chemistry and Biochemistry/Chemical Engineering 467. The course, entitled Biochemistry and Biotechnology Laboratory is aimed at preparing undergraduates with laboratory skills necessary to participate in research in biology, biochemistry, chemistry, and chemical engineering. 8) Involved a cohort of 23 undergraduates in biomedically-relevant research projects through the summer undergraduate internship program. Emphasis continues to involve a diverse student group. The 2005 group included 60% women and 30% underrepresented students, and involved more than 30 faculty members at all Delaware INBRE partner institutions. 9) Provided guidance and leadership to the INBRE participants toward successful implementation of program goals. Assured that program objectives of all six INBRE Cores are met. Coordinated and oversaw financial and program management. 10) Contributed to the increase in NIH funding to the State of Delaware - from $14.9 Million in 2000 to $26.5 Million in 2005.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。特拉华州INBRE 2006年度进展报告（APR）批准号：2 P20 RR 016472 -2006 行政核心报告核心目标：行政核心提供全州范围内的领导和协调伙伴机构之间的方案活动。 大卫博士S. INBRE PI Weir和INBRE行政总监Karl V. Steiner博士同时也是特拉华州生物技术研究所（DBI）的主任和副主任，他们领导着特拉华州INBRE行政核心。 行政核心在第二年的成就包括：1）从BRIN的基础设施建设重点过渡到INBRE的研究重点，并在特拉华州（UD），特拉华州州立大学，海伦F。克里斯蒂娜保健系统和内穆尔儿童医院的格雷厄姆癌症中心。继续在参与机构之间发展健康、建设性的平等伙伴关系。 2)参与了转化癌症研究中心的组建，作为在特拉华州发展医学研究能力的倡议的一部分，涉及DBI和UD的生物科学系，Nemours儿童医院和Helen F.格雷厄姆癌症中心在克里斯蒂安娜护理，国家最大的医疗保健提供者。特拉华州INBRE教师正在领导一个由科学家和医生组成的转化研究工作组，该工作组现在每隔六个月举行一次会议，以了解癌症转化研究的最新研究情况。该小组现在包括特拉华州的研究人员以及来自费城金梅尔癌症中心（杰斐逊医学院）和福克斯蔡斯癌症中心的区域研究人员。谈判正在进行中，以包括心血管领域的转化研究。与托马斯杰斐逊大学，特拉华州的医学院正在进行平行谈判，为医学生和医生开发基于虚拟现实的教育和培训计划。 3)征求了第二轮INBRE研究提案，更有针对性地关注癌症的基础和转化研究。研究委员会和外部咨询委员会批准了13个新项目，开始于2006年6月。4)制定了一个实质性的评估过程，包括美国科学促进会一年两次的现场访问，特拉华州大学教育研究与发展中心进行的内部评估过程，以及定期向特拉华州INBRE外部咨询委员会通报情况。正在开发一个在线用户界面和评价数据库。 评价进程的初步结果导致从一个未执行方案中重新分配资金。 5)继续开发仪器核心的能力并评估其有效性。例如，由INBRE/COBRE联合资助的生物信息学基础设施支持了特拉华州大学在小RNA方面的开创性工作。 微阵列已不再被重视，并已被纳入一个多用途的核心包含微阵列，测序和蛋白质生产。 6)影响了护理的UD学校的研究作用的增加，学生参与教师的研究项目，并推出了一个新的课程，cross 362，护理研究概念。 7)继续在特拉华州大学化学和生物化学/化学工程467开设新的双列课程的试点阶段。该课程名为“生物化学和生物技术实验室”，旨在为本科生提供参与生物学、生物化学、化学和化学工程研究所需的实验室技能。 8)通过暑期本科生实习计划，涉及23名本科生的生物医学相关研究项目。重点继续涉及不同的学生群体。2005年的小组包括60%的妇女和30%的代表性不足的学生，并涉及30多名教师在所有特拉华州INBRE合作机构。 9)为INBRE参与者成功实现计划目标提供指导和领导。确保满足所有六个INBRE核心的计划目标。协调和监督财务和项目管理。 10)帮助国家卫生研究院增加对特拉华州的资助-从2000年的1 490万美元增加到2005年的2 650万美元。