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Nanotechnology for Multiplexed and Intraoperative Cancer Detection

用于多重和术中癌症检测的纳米技术

基本信息

批准号：
7944053
负责人：
SHUMING NIE
金额：
$ 101.76万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944053
关键词：
Address Affinity Animal Model Applications Grants Basic Science Benign Biocompatible Biological Markers Breast Breast Cancer Model Cancer Detection Cancer Patient Clinical Clinical Engineering Clinical Medicine Clinical Trials Collaborations Color Comparative Study Computer software Computers and Advanced Instrumentation Databases Detection Development Devices Dyes Employment Opportunities Engineering Environment Epidermal Growth Factor Receptor Excision FDA approved Faculty Fluorescence Foundations Goals Gold Gold Colloid Hand Human Image Imagery Indocyanine Green Institution Joints Lasers Lead Left Lesion Ligands Lung Lung Neoplasms Malignant - descriptor Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of pancreas Measurement Medical Medical Oncology Micrometastasis Microscopic Modeling Monitor Nanotechnology Nature Neoplasm Metastasis Nodule Normal tissue morphology Operating Rooms Operative Surgical Procedures Optics Outcome Outcome Study Pancreas Paper Patients Peer Review Grants Pennsylvania Primary Neoplasm Procedures Prostate Publishing Quantum Dots Radiation therapy Recurrence Reporting Research Research Personnel Resected Residual Tumors Resolution Rheumatoid Arthritis Robotics Science Semiconductors Sensitivity and Specificity Signal Transduction Solid Neoplasm Standardization Surface Surgeon Surgical Oncology System Systems Integration Techniques Time Tissues Translating Universities Urokinase Plasminogen Activator Receptor Work base biocomputing cancer cell cancer recurrence cancer surgery chemotherapy college design experience folate-binding protein improved innovation innovative technologies instrument instrumentation lymph nodes malignant breast neoplasm medical schools miniaturize minimally invasive molecular imaging mortality nanoparticle nanoprobe neoplastic cell new technology prevent programs prototype public health relevance research study spectroscopic imaging tumor tumor xenograft

项目摘要

DESCRIPTION (Provided by the applicant): This GO grant application aims to integrate the unique capabilities of nanotechnology and innovative optical instrumentation for broad applications in cancer surgery. The rationale for this surgical nanotechnology focus is that surgery currently cures approximately 45% of all patients with cancer, while chemotherapy and radiation therapy together only cure 5%. In fact, the single most important predictor of patient survival for almost all cancers is a complete surgical resection, by removing the primary tumor, draining lymph nodes and small adjacent satellite nodules. For human lung, breast, prostate, colon and pancreatic cancers, it has been shown that complete resection has a three to five fold improvement in survival compared to partial or incomplete resection. In the last 50 years, little progress has been made in improving intraoperative techniques, and currently over 40% of patients that undergo surgery still leave the operating room without a complete resection due to missed lesions. Thus, major opportunities exist to develop nanoparticle agents and intraoperative instrumentation that would allow a surgeon to visualize microscopic tumors, metastatic lymph nodes, and adjacent normal tissues during cancer surgery. This has the potential to make an enormous impact on a larger number of patients undergoing cancer surgery. Toward this goal, we propose here a translational and collaborative program involving 7 senior faculty investigators at three academic institutions (Emory, Georgia Tech, and the University of Pennsylvania) with broad expertise cutting across nanotechnology, biocomputing, molecular imaging, oncologic surgery, and medical oncology. Designed for accelerated development and clinical impact within two years, the overall project will focus on three major efforts: (1) optimization and standardization of a new class of biocompatible and nontoxic nanoparticle probes based on pegylated colloidal gold and surface-enhanced Raman scattering (SERS) (Nie and coworkers, Nature Biotech. 26, 83-90, 2008); (2) systems integration and implementation for intraoperative cancer detection and visualization, especially by using handheld "point-and-detect" devices; and (3) translational experiments demonstrating nanotechnology surgical applications in animal models of aggressive tumors such as lung cancer, pancreatic cancer, and metastatic breast cancer. The proposed research could ultimately make an impact in reducing the currently high mortality rates of these and other human malignancies. Once developed, the nanoparticle agents and miniaturized optical devices can also be used for robotic and minimally invasive surgery, such as endoscopic and laparoscopic procedures to detect and resect solid tumors. This project is expected to yield several practical outcomes including standardized gold nanoparticles for multiplexed cancer detection, new spectroscopic and imaging instruments for cancer detection, software and databases for multiplexed spectral imaging and tissue identification, as well as new employment opportunities. Public Health Relevance: This grant application aims to develop new and innovative technologies for applications in cancer surgery. The main goals are to help the surgeon to delineate tumor margins, to identify residual tumor cells and micrometastases, and to determine if the tumor has been completely removed. This work is expected to ultimately make an impact in reducing the currently high mortality rates of lung, pancreatic and metastatic breast cancers.

描述(由申请人提供)：这项GO赠款申请旨在整合纳米技术和创新的光学仪器的独特能力，以在癌症手术中广泛应用。这种外科纳米技术的基本原理是，目前外科手术治愈了大约45%的癌症患者，而化疗和放射治疗加在一起只治愈了5%。事实上，几乎所有癌症患者存活的唯一最重要的预测因素是完整的手术切除，即切除原发肿瘤，引流淋巴结和邻近的小卫星结节。对于人的肺癌、乳腺癌、前列腺癌、结肠癌和胰腺癌，已有研究表明，与部分或不完全切除相比，完全切除可使生存率提高3至5倍。在过去的50年里，术中技术的改进进展甚微，目前超过40%的接受手术的患者由于遗漏病变而离开手术室而没有完全切除。因此，开发纳米粒子制剂和术中器械的机会很大，使外科医生能够在癌症手术期间可视化显微肿瘤、转移的淋巴结和邻近的正常组织。这有可能对更多接受癌症手术的患者产生巨大影响。为了实现这一目标，我们在这里提出了一个翻译和协作计划，涉及三个学术机构(埃默里大学、佐治亚理工学院和宾夕法尼亚大学)的7名高级教职研究员，他们拥有横跨纳米技术、生物计算、分子成像、肿瘤外科和医学肿瘤学的广泛专业知识。为了在两年内加速开发和产生临床效果，整个项目将集中于三个主要方面：(1)优化和标准化基于聚乙二醇化胶体金和表面增强拉曼散射(SERS)的新型生物相容性和无毒纳米颗粒探测器(NIE及其同事，自然生物技术)。26，83-90,2008)；(2)术中癌症检测和可视化的系统集成和实施，特别是通过使用手持“点和检测”设备；(3)在肺癌、胰腺癌和转移性乳腺癌等侵袭性肿瘤的动物模型中展示纳米技术外科应用的转化实验。拟议的研究最终可能对降低这些和其他人类恶性肿瘤目前的高死亡率产生影响。一旦开发出来，纳米制剂和微型光学设备也可以用于机器人和微创手术，例如内窥镜和腹腔镜手术，以检测和切除实体肿瘤。该项目预计将产生若干实际成果，包括用于多路复用癌症检测的标准化金纳米颗粒、用于癌症检测的新光谱和成像仪器、用于多路复用光谱成像和组织识别的软件和数据库以及新的就业机会。公共卫生相关性：这项拨款申请旨在开发新的创新技术，应用于癌症手术。主要目标是帮助外科医生勾勒出肿瘤边缘，识别残留的肿瘤细胞和微转移，并确定肿瘤是否已完全切除。预计这项工作最终将对降低目前肺癌、胰腺癌和转移性乳腺癌的高死亡率产生影响。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Stimuli-responsive nanoparticles for targeting the tumor microenvironment.

DOI：
10.1016/j.jconrel.2015.08.050
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
0
作者：
Du J;Lane LA;Nie S
通讯作者：
Nie S

Local recurrence following lung cancer surgery: incidence, risk factors, and outcomes.