Beyond Biomaterials: Engineering the Wound Bed

描述(申请人提供)：仅在美国，每年就有超过600万例慢性皮肤创伤，包括但不限于静脉淤积性溃疡、糖尿病溃疡和压疮，影响到2%的总人口和15%的老年人。因此，在慢性伤口护理产品上花费了超过85亿美元，为纠正这种伤口进行了5000万次外科手术，导致在治疗上花费了200多亿美元。不幸的是，这种创伤的发生率只会随着年龄的增长而上升。慢性创伤不仅扰乱了数百万公民的生活质量，而且还造成生产力损失和医疗保健费用方面的社会经济负担。我们建议在加州大学戴维斯分校和威斯康星大学麦迪逊分校组建一个由经验丰富的研究人员组成的跨学科团队，他们的目标是通过设计伤口床本身来修复调节失调的伤口，从而超越传统的治疗病理性伤口的策略。我们新颖的核心主张是，应该有可能改变伤口床的表面化学和生物物理特性，以促进促进伤口愈合的良好细胞行为。该方法寻求将蛋白质化学、表面化学功能化和纳米制造方面的最新进展转化为潜在地深刻影响患者生活质量的临床环境。拟议的计划将利用两个校区不同学科的有经验的研究人员来实现一个单一的目标：开发和优化新的方法来设计伤口床本身，以促进有利的患者结果。

DESCRIPTION (provided by applicant): In the United States alone, there are over 6 million cases of chronic skin wounds each year, including but not limited to venous stasis ulcers, diabetic ulcers, and pressure sores, impacting two percent of the entire population and 15% of the elderly. Consequently, there is over $8.5 billion spent on chronic wound care products with 50 million surgical procedures to correct such wounds, resulting in more than $20 billion spent on treatment. And, unfortunately, the incidence of such wounds only rises with increasing age. Chronic wounds not only disrupt the quality of life for millions of citizens but also impart a socio-economic burden in terms of lost productivity and health care dollars. We propose to assemble an interdisciplinary team of accomplished investigators at the University of California, Davis and the University of Wisconsin-Madison, who aim to go beyond conventional strategies for treating pathologic wounds by developing novel strategies to repair dysregulated wounds by engineering of the wound bed itself. Our novel, core proposition is that it should be possible to alter the surface chemistry and biophysical characteristics of the wound bed to promote favorable cell behaviors that accelerate wound healing. The approach seeks to translate recent advances in protein chemistry, surface chemical functionalization and nanofabrication to the clinical setting with potential to profoundly impact the quality of patient lives. The proposed program will harness accomplished investigators in diverse disciplines across two campuses to a singular goal: Development and optimization of novel methods to engineer the wound bed itself to promote favorable patient outcomes