Endocrine Relationships Preceding Precocious Puberty (pilot)

性早熟之前的内分泌关系（试点）

• 批准号: 8019542
• 负责人: RANDY L STANKO
• 金额: $ 1.84万
• 依托单位: TEXAS A&M UNIVERSITY-KINGSVILLE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8019542
• 关键词: Acceleration; Adipose tissue; Adolescence; Adult; Affect; African American; Age; Age of Onset; Agonist; Alternative Therapies; Animal Model; Body mass index; Bone Growth; Cattle; Characteristics; Child; Childhood; Chronic; Clinical; Clinical Treatment; Complex; Data; Delayed Puberty; Development; Diet; Disease; Economics; Employee Strikes; Endocrine; Endocrinology; Estrogens; Estrous Cycle; Event; Exhibits; Family suidae; Female; Fertilization; Future; Genetic; Genotype; Goals; Gonadal Steroid Hormones; Gonadotropin Hormone Releasing Hormone; Gonadotropins; Growth; Hispanics; Homeostasis; Human; Hypothalamic structure; Investigation; Knowledge; Lead; Link; Liver; Maintenance; Mammals; Measures; Menarche; Metabolic; Modeling; Neurosecretory Systems; Nutritional status; Obesity; Ovarian; Ovulation; Pathology; Patients; Peripheral; Physiological; Pilot Projects; Pituitary Gland; Population; Population Study; Postpartum Period; Precocious Puberty; Pregnancy Maintenance; Puberty; Pump; Race; Regulation; Reporting; Reproduction; Reproductive Endocrinology; Reproductive system; Research; Research Project Grants; Review Literature; Science; Sex Characteristics; Sexual Development; Sexual Maturation; Signal Transduction; Somatotropin; Study models; Sushi Domain; Testing; Time; Tissues; Weaning; Work; base; bone; design; editorial; feeding; girls; hypothalamic pituitary gonadal axis; implantation; in utero; in vivo Model; innovation; male; meetings; normal aging; nutrition; premature; prevent; programs; psychosocial; racial difference; reproductive; reproductive axis; reproductive development; reproductive success; response; socioeconomics

Genotype, level of nutrition, metabolic signals, adiposity, and growth rate all have profound influence on the neuroendocrine system that regulates hypothalamic-pituitary-gonadal axis (HPGA) in mammals. These factors can modify the rate of sexual maturation and age at first ovulation (puberty). It is not fully understood which of these factors has a predominant influence on reproductive development. Central precocious puberty (CPP) is a phenomonen that has been clinically studied since the latter half of the 19th century and involves the premature reemergence of gonadotropin-releasing hormone (GnRH) secretion during childhood, activating a cascade of pituitary-gonadal and physical maturation. Clinical conditions of CPP involve thelarche, menarche, and acceleration of linear growth and bone maturation. Racial differences exist in sexual maturation with 48% of African-American, ¿ 25% of Hispanic, and 15% of white girls exhibiting secondary sexual characteristics by age 8. Girls whose thelarche begins between 2 and 6 yr of age often have rapidly progressive pubertal development consistent with CPP. True CPP is of concern because of underlying disorders that may be causing premature sexual development. The dramatic psychosocial implications of CPP are troubling, as there is no natural progression into the teenage years. The current clinical treatment for patients with CPP is administration of long acting GnRH agonists. The long-term aim of this research program is to elucidate developmental relationships between reproduction and growth in developing females and identify specific endocrine signals that influence the occurrence of CPP. The specific aim of this pilot project is to investigate chronic GnRH administration in a bovine animal model with precociously induced puberty to contribute to the understanding of mechanisms underlying the onset of puberty in female mammals. Proposed research is designed to establish reproductive, growth, and endocrine characteristic of these precocious females. Chronic GnRH administration, by osmotic pump, will suppress the HPGA (via lower gonadotropin and gonadal steroid secretion) in an animal model that has been induced to exhibit precocious puberty and enhanced adiposity. Results will provide metabolic, growth, and endocrine relationships that exist in females with CPP, and serve as a basis for future research projects to further our understanding of reproductive development and facilitate alternative clinical therapies for CPP.

基因型、营养水平、代谢信号、肥胖和生长速度都对其有深远的影响