Center for Childhood Asthma in the Urban Environment

描述（由申请人提供） 城市环境中儿童哮喘中心（CCAUE）的长期目标是了解室内外空气颗粒物和过敏原暴露如何导致巴尔的摩内城哮喘儿童的气道炎症和呼吸道疾病，并确定新的机会和策略，以减少与这些暴露相关的发病率。指导该中心拟议研究的总体假设是，室内空气污染（颗粒物和过敏原）会增加氧化应激，导致儿童气道炎症和哮喘发病率增加。研究人员组建了一个多学科的综合研究团队，研究氧化应激和气道炎症在哮喘发病率中的作用，以开发新的生物标志物，深入了解易感基因型，提供更好的临床管理，并确定干预（环境和药理学）的机会。 该计划概述了一个多学科计划，旨在解决这一假设和长期目标。本中心申请包括以下两个面向临床和面向机制的研究项目：面向临床的研究项目：项目1 -国内室内PM与儿童哮喘发病;项目2 -PM鼻挑战期间的氧化应激/炎症和面向机制的研究项目：项目3 -哮喘中氧化应激的Nrf 2依赖性调节;项目4 -PM诱导的树突状细胞活化的机制。 综合性（临床和基础）和跨学科性质

DESCRIPTION (provided by applicant) The long-term goal of the Center for Childhood Asthma in the Urban Environment (CCAUE) is to understand how exposures to indoor and outdoor airborne particulate matter and allergens may result in airway inflammation and respiratory morbidity in children with asthma living in the inner city of Baltimore and to identify novel opportunities and strategies to reduce morbidity associated with these exposures. The overarching hypothesis guiding the Center's proposed research is that indoor air pollution (particulate matter and allergens) produces increased oxidative stress which leads to increased airway inflammation and asthma morbidity in children. The investigators have assembled a multidisciplinary and integrated team of researchers to investigate the role oxidative stress, and airway inflammation in asthma morbidity in order to develop new biomarkers of effect, provide insight into susceptible genotypes, offer better clinical management, and to identify opportunities for intervention (environmental and pharmacologic). This program outlines a multidisciplinary program directed to address this hypothesis and long-term goal. This Center application includes the following two clinically-oriented and mechanistically-oriented research projects: Clinically-Oriented Research Projects: Project 1 - Domestic Indoor PM and Childhood Asthma Morbidity; Project 2 - Oxidative Stress/Inflammation during PM Nasal Challenge and Mechanistically-Oriented Research Projects: Project 3 - Nrf2 Dependent Regulation of Oxidative Stress in Asthma; Project 4 - Mechanisms of PM-Induced Dendritic Cell Activation. INTEGRATED (clinical and basic) and INTERDISCIPLINARY NATURE OF PROGRAM