Bladder Wall Remodeling in LUTS

LUTS 中的膀胱壁重塑

• 批准号: 7868944
• 负责人: SAMUEL K. CHACKO
• 金额: $ 5.14万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-31 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7868944
• 关键词: Bladder; Wall; Remodeling; LUTS

The George M. O'Brien Urology Research Center at the University of Pennsylvania entitled "Bladder Wall Remodeling in LUTS " has three key elements: 1) the laboratories of five principal investigators and their Co-Is that bring expertise in molecular biology, cellular biology, neuroscience, biochemistry, physiology, pharmacology, and pathology; 2) an Administrative Core (Core A) to provide administrative and fiscal oversight, quality control for the research within individual projects and coordination of the research and interactions in the Center, 3) a Bladder Tissue Core (Core B) to serve as resource for smooth muscle tissue of the LUTS from rabbits, rats, and mice (normal and obstructed bladders and urethra). In addition, we have Educational & Enrichment and Pilot and Feasibility (P&F) programs to attract young investigators and established investigators working in other biomedical areas to urologic research. The four projects are: 1) "Social-stress-induced urinary dysfunction: A model of dysfunctional voiding" from Rita Valentino, 2) "Bladder wall remodeling following alteration of urothelial structure" from Pam Howard (in collaboration with Dr. Tung-Tien Sun at NYU), 3) entitled "Mechanism for obstruction-induced detrusor remodeling: Role of hypoxia & stretch" from Samuel K. Chacko, and 4) entitled "Extracellular Matrix Changes in Response to Obstruction" from Edward Macarak. In addition, we have two P&F projects, one from Shaohua Chang entitled "Urethral function in females: A Role for estrogen" and one from Gina Northington entitled "The effect of PBOO and estrogen on detrusor smooth muscle in female rabbits." The focus of this O'Brien Program is to elucidate the mechanism for social stress- and PBOO-induced functional and structural changes in the bladder wall leading to LUTS. These studies will provide a useful model for dysfunctional voiding in children and elucidate the molecular basis for urinary dysfunction in menopausal women and aging men with BPHinduced PBOO. A better understanding of the basic mechanisms for alteration of the structure and function of the bladder wall and urethra in LUTS would help to develop therapeutic strategies targeting altered molecular events that cause altered function in the lower urinary tract.

该乔治M。宾夕法尼亚大学奥布莱恩泌尿学研究中心题为“膀胱壁 LUTS中的重塑“有三个关键要素：1）五个主要研究者的实验室及其 带来分子生物学，细胞生物学，神经科学，生物化学，生理学， 药理学和病理学; 2）行政核心（核心A），提供行政和财政 监督，个别项目内研究的质量控制和研究的协调， 3）膀胱组织核心（核心B），用作平滑肌组织的来源 来自兔、大鼠和小鼠的LUTS（正常和阻塞的膀胱和尿道）。另外我们有 教育和丰富以及试点和可行性（P&F）计划，以吸引年轻的研究人员， 在其他生物医学领域工作的研究人员建立了泌尿学研究。这四个项目是：1） “社会压力引起的泌尿功能障碍：排尿功能障碍的模型”，来自Rita Valentino，2） “尿路上皮结构改变后的膀胱壁重塑”，来自Pam霍华德（与 博士Tung-Tien Sun在纽约大学），3）题为“梗阻诱导逼尿肌重塑的机制： 缺氧和拉伸”，来自Samuel K. Chacko，和4），题为“细胞外基质变化响应于 妨碍公务”出自爱德华·马卡拉克之手。另外，我们有两个P&F项目，一个来自张少华 题为“女性的尿道功能：雌激素的作用”和吉娜·诺辛顿的题为“ PBOO和雌激素对雌兔逼尿肌平滑肌的影响。“这个奥布莱恩计划的重点是 阐明社会压力和PBOO诱导的功能和结构变化的机制， 膀胱壁导致LUTS。这些研究将为儿童排尿功能障碍提供一个有用的模型 并阐明BPH引起的绝经期妇女和老年男性排尿功能障碍的分子基础。 PBOO。更好地理解结构和功能改变的基本机制 膀胱壁和尿道的LUTS将有助于制定治疗策略， 导致下尿路功能改变的分子事件。