Adolescent Alcohol Use: Developmental & Long-Term Risks

描述（由申请人提供）： 越来越多的证据表明，青少年酒精暴露对生理和行为发育产生有害影响，并显着增加成年后过度饮酒的脆弱性。拟议的研究广泛旨在将青少年发育时间段描述为酒精诱导损伤的独特风险窗口，并调查青春期戒酒是否具有保护作用，增加猕猴对给药的弹性，从而可靠地产生过量乙醇消耗模式。我们建议使用这个模型来研究青少年时期酗酒模式对生理和行为发育的影响，并随后将其作为成年期饮酒量增加的风险因素。通过使用纵向设计，以及组间比较的动物暴露于酒精在青春期，动物首次暴露于成年期，和禁欲的动物从未暴露于酒精，我们将能够检查潜在的添加剂或交互作用的青少年酒精暴露，以确定是否成人暴露的结果是改变以前的酒精经验。酒精影响的程度和寿命将在成年人长期饮酒后的组间比较中显而易见。最后，将在洗脱期评估酒精诱导损伤的恢复情况。将在洗脱期评估酒精诱导损伤的恢复情况，然后有机会恢复饮酒。最后，酒精自我管理的扩展阶段将以酒精摄入的滥用模式为特征，这些模式持续了成年生活的很大一部分。

DESCRIPTION (provided by applicant): Growing evidence suggests that adolescent alcohol exposure has deleterious effects on physiological and behavioral development and significantly increases vulnerability to excessive alcohol consumption in adulthood. The proposed studies broadly aim to characterize the adolescent developmental time period as a unique window of risk for alcohol-induced damage and to investigate whether abstention from alcohol in adolescence is protective, increasing resilience to administration in macaque monkeys that reliably produces a pattern of excessive ethanol consumption. We propose to use this model to investigate the effects of a binge-pattern alcohol exposure during the adolescent period on physiological and behavioral development, and subsequently, as a risk factor or increased alcohol consumption during adulthood. By using a longitudinal design, as well as between-groups comparison of animals exposed to alcohol during adolescence, animals first exposed during adulthood, and abstinent animals never exposed to alcohol, we will be able to examine potential additive or interactive effects of adolescent alcohol exposure in order to determine whether the outcome of adult exposure is altered by previous alcohol experience. The extent and longevity of alcohol effects will be evident from group comparisons after extended adult alcohol consumption. Finally, recovery from alcohol-induced damage will be assessed during a wash-out period. Recovery from alcohol-induced damage will be assessed during a wash-out period followed by opportunity to resume drinking. The final, extended phase of alcohol self-administration will characterize abusive patterns of alcohol intake that endure through a significant portion of adult life.