Adolescent Alcohol Use: Developmental & Long-Term Risks

青少年饮酒：发育

• 批准号: 7850087
• 负责人: ALLYSON J BENNETT
• 金额: $ 9.19万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850087
• 关键词: Adolescence; Adolescent; Adult; Affective; Aggressive behavior; Alcohol consumption; Alcohol-Induced Disorders; Alcohols; Animals; Behavior; Behavioral; Brain; Cognitive; Development; Developmental Process; Doctor of Philosophy; Goals; Heavy Drinking; Impulsivity; Insulin-Like Growth Factor I; Lead; Life; Longevity; Macaca; Magnetic Resonance Imaging; Memory; Modeling; Monkeys; Neurocognitive; Neurosecretory Systems; Oral; Outcome; Pattern; Phase; Physiological; Recovery; Relative (related person); Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Self Administration; Self-Administered; Social Behavior; Somatotropin; Stress; Testosterone; Time; adolescent alcohol; adolescent alcohol exposure; alcohol during adolescence; alcohol effect; alcohol exposure; alcohol use initiation; comparison group; drinking; emerging adult; executive function; experience; longitudinal design; resilience; social; social skills; underage drinking

DESCRIPTION (provided by applicant): Growing evidence suggests that adolescent alcohol exposure has deleterious effects on physiological and behavioral development and significantly increases vulnerability to excessive alcohol consumption in adulthood. The proposed studies broadly aim to characterize the adolescent developmental time period as a unique window of risk for alcohol-induced damage and to investigate whether abstention from alcohol in adolescence is protective, increasing resilience to administration in macaque monkeys that reliably produces a pattern of excessive ethanol consumption. We propose to use this model to investigate the effects of a binge-pattern alcohol exposure during the adolescent period on physiological and behavioral development, and subsequently, as a risk factor or increased alcohol consumption during adulthood. By using a longitudinal design, as well as between-groups comparison of animals exposed to alcohol during adolescence, animals first exposed during adulthood, and abstinent animals never exposed to alcohol, we will be able to examine potential additive or interactive effects of adolescent alcohol exposure in order to determine whether the outcome of adult exposure is altered by previous alcohol experience. The extent and longevity of alcohol effects will be evident from group comparisons after extended adult alcohol consumption. Finally, recovery from alcohol-induced damage will be assessed during a wash-out period. Recovery from alcohol-induced damage will be assessed during a wash-out period followed by opportunity to resume drinking. The final, extended phase of alcohol self-administration will characterize abusive patterns of alcohol intake that endure through a significant portion of adult life.

描述（由申请人提供）：

项目成果

Challenges to bonnet monkey (Macaca radiata) social groups: Mother-infant dyad and infant social interactions.

• DOI: 10.1002/dev.20449
• 发表时间: 2010-07
• 期刊: DEVELOPMENTAL PSYCHOBIOLOGY
• 影响因子: 2.2
• 作者: Laudenslager, Mark L.;Natvig, C.;Mikulich-Gilbertson, S. M.;Blevins, M.;Corcoran, C.;Pierre, P. J.;Bennett, A. J.
• 通讯作者: Bennett, A. J.

Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood.

• DOI: 10.1002/dev.20613
• 发表时间: 2012-07
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: Corcoran CA;Pierre PJ;Haddad T;Bice C;Suomi SJ;Grant KA;Friedman DP;Bennett AJ
• 通讯作者: Bennett AJ

Multidimensional cost-benefit analysis to guide evidence-based environmental enrichment: providing bedding and foraging substrate to pen-housed monkeys.

多维成本效益分析指导循证环境富集：为圈养猴子提供垫料和觅食基质。

• 发表时间: 2010
• 期刊: Journal of the American Association for Laboratory Animal Science : JAALAS
• 作者: Bennett,AllysonJ;Corcoran,ChristopherA;Hardy,VickieA;Miller,LeslieR;Pierre,PeterJ
• 通讯作者: Pierre,PeterJ