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Procedures to Assess the Hazards of a Superfund Site

评估超级基金场地危害的程序

基本信息

批准号：
7923667
负责人：
Stephen H. Safe
金额：
$ 5.03万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7923667
关键词：
Adverse effects Affect Biological Biological Markers Biological Testing Chemicals Collaborations Communities Complex Complex Mixtures Congenital Abnormality Data Development Drug Metabolic Detoxication Ecosystem Endocrine disruption Environment Exposure to Genetic Genetic Predisposition to Disease Health Human Image Analysis Incidence Individual Measurement Measures Mediating Methods Modeling Nutritional Organism Population Predisposition Principal Investigator Procedures Process Protocols documentation Research Research Project Grants Risk Risk Assessment Site Students Superfund Techniques Texas Training Translational Research Uncertainty United States Environmental Protection Agency Universities base cell injury field study fundamental research gene environment interaction genotoxicity hazard improved novel outreach programs receptor remediation superfund chemical superfund site toxicant

项目摘要

DESCRIPTION (provide by applicant) The proposed SBRP at Texas A&M University will utilize an integrated research model to investigate the potential adverse ecological and human health effects of Superfund chemicals and mixtures to improve the risk assessment paradigm. The major objective of the Program is to conduct fundamental research to reduce the uncertainty associated with risk assessment of complex mixtures, and to improve scientific and public confidence in the overall risk assessment process. The applicants hypothesize that adverse environmental and human health effects resulting from exposure to Superfund-related chemical mixtures are multi-factorial and associated with interactions of individual chemicals and their disposition, as well as exposure of target biological receptors and their genetic sensitivities. The proposed studies include three mechanism-based research projects focused on Superfund toxicants that act through endocrine disruption, genotoxicity and cellular injury. Project 4 will investigate genetic susceptibility and predisposition to chemical-induced birth defects. The development of novel methods for remediation of contaminated media will be carried out in Project 5. Human and ecosystem exposure and risk assessment studies will be investigated in Project 6. Project 7 will investigate gene-environment interactions affecting the risk of birth defects. Research in the seven individual projects will be supported by the Image Analysis, Analytical, Field Studies, Administrative, and Training Cores. The Program also includes a Research Translation Core that will expand ongoing collaborations with Regional Site Managers at the United States Environmental Protection Agency (USEPA) to facilitate incorporation of biological test protocols into risk assessment at Superfund sites. An Outreach Core will communicate research results to community groups and students.

描述（由申请人提供）

项目成果

期刊论文数量（240）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.

DOI：
10.1016/j.taap.2011.03.009
发表时间：
2011-05-15
期刊：
Toxicology and applied pharmacology
影响因子：
3.8
作者：
Barhoumi R;Mouneimne Y;Ramos E;Morisseau C;Hammock BD;Safe S;Parrish AR;Burghardt RC
通讯作者：
Burghardt RC

Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.

DOI：
10.1371/journal.pone.0026589
发表时间：
2011
期刊：
PloS one
影响因子：
3.7
作者：
Zhou GD;Zhu H;Phillips TD;Wang J;Wang SZ;Wang F;Amendt BA;Couroucli XI;Donnelly KC;Moorthy B
通讯作者：
Moorthy B

Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures.

DOI：
10.1007/s00204-014-1285-8
发表时间：
2015-06
期刊：
ARCHIVES OF TOXICOLOGY
影响因子：
6.1
作者：
Phillips, Tracie D.;Richardson, Molly;Cheng, Yi-Shing Lisa;He, Lingyu;McDonald, Thomas J.;Cizmas, Leslie H.;Safe, Stephen H.;Donnelly, Kirby C.;Wang, Fen;Moorthy, Bhagavatula;Zhou, Guo-Dong
通讯作者：
Zhou, Guo-Dong

Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity.