Ontogeny of the airway smooth muscle layer in health and disease

健康和疾病中气道平滑肌层的个体发育

• 批准号: nhmrc : GNT1077791
• 负责人: A/Pr Jane Pillow
• 金额: $ 51.98万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ontogeny-airway-smooth-health-disease/1345167
• 关键词: Ontogeny; airway; smooth; muscle; layer

In asthmatic patients the thickness of the airway smooth muscle (ASM) layer is increased early in life and even before doctor-diagnosis. An intriguing possibility is our overarching hypothesis that the ASM layer is thickened from birth and represents an independent risk factor for the development of asthma. This project strives to understand better how the ASM layer matures from late gestation to adulthood and whether abnormal maturation contributes to disease susceptibility.

在哮喘患者中，气道平滑肌（ASM）层的厚度在生命早期甚至在医生诊断之前增加。一个有趣的可能性是我们的总体假设，即ASM层从出生开始增厚，是哮喘发展的独立危险因素。该项目致力于更好地了解ASM层如何从妊娠晚期成熟到成年，以及异常成熟是否有助于疾病易感性。