FACILITIES IN RESEARCH EXCELLENCE (FORE) IN SPINAL CORD INJURY (SCI) REPLICATION

该合同的目标是：(1)对有前景的已发表的研究进行重复研究，这些研究报道了促进脊髓损伤后恢复的干预措施，特别是在亚急性或慢性损伤环境中促进再生和干预的策略；(2)比较不同单独治疗和联合治疗的疗效。该复制项目的总体目的是确定潜在SCI治疗的可重复性和稳健性，从而确定适合转化为临床前和最终临床试验的潜在治疗方法。我们建议开展至少5项涉及增强轴突再生的操作研究，或10项旨在增强功能恢复的急性损伤后干预研究，或由独立科学指导委员会选择确定两者的结合。这些重复研究将通过额外的组或分析进行扩充，这些组或分析将测试在原始研究方法框架内有意义的组合策略，或将原始工作与新治疗组或两者进行直接比较。

The objectives for this contract are to (1) undertake replications of promising published studies reporting interventions to promote recovery after spinal cord injury focusing especially on strategies to promote regeneration and interventions in a sub-acute or chronic injury setting; (2) compare the efficacy of different individual treatments and treatment combinations. The overall reationale of the replication project is to determine the reproducibility and robustness of potential SCI treatments so as to identify potential therapies suitable for translation to pre-clinical and eventually clinical testing. We propose to carry out a minimum of 5 studies that involve manipulations to enhance axon regeneration or 10 studies of interventions during the acute post-injury period designed to enhance recovery of function, or a combination of the two as determined through selection by an independent Scientific Steering Committee. These replications will be augmented with additional groups or analyses that test either combination strategies that make sense within the framcwork of the methods of the original studies or provide a direct comparison of the original work with novel treatment groups or both.