FACILITIES IN RESEARCH EXCELLENCE (FORE) IN SPINAL CORD INJURY (SCI) REPLICATION

脊髓损伤 (SCI) 复制方面的卓越研究设施

• 批准号: 7952545
• 负责人: OSWALD STEWARD
• 金额: $ 92.66万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952545
• 关键词: FACILITIES; RESEARCH; EXCELLENCE; FORE; SPINAL

The objectives for this contract are to (1) undertake replications of promising published studies reporting interventions to promote recovery after spinal cord injury focusing especially on strategies to promote regeneration and interventions in a sub-acute or chronic injury setting; (2) compare the efficacy of different individual treatments and treatment combinations. The overall reationale of the replication project is to determine the reproducibility and robustness of potential SCI treatments so as to identify potential therapies suitable for translation to pre-clinical and eventually clinical testing. We propose to carry out a minimum of 5 studies that involve manipulations to enhance axon regeneration or 10 studies of interventions during the acute post-injury period designed to enhance recovery of function, or a combination of the two as determined through selection by an independent Scientific Steering Committee. These replications will be augmented with additional groups or analyses that test either combination strategies that make sense within the framcwork of the methods of the original studies or provide a direct comparison of the original work with novel treatment groups or both.

该合同的目标是 (1) 复制有前景的已发表研究，报告促进脊髓损伤后恢复的干预措施，特别关注在亚急性或慢性损伤环境中促进再生和干预的策略； (2)比较不同个体治疗和治疗组合的疗效。 复制项目的总体理由是确定潜在 SCI 治疗的可重复性和稳健性，从而确定适合转化为临床前和最终临床测试的潜在疗法。 我们建议开展至少 5 项涉及增强轴突再生的操作的研究，或 10 项旨在增强功能恢复的急性损伤后时期干预措施的研究，或由独立科学指导委员会选择确定的两项研究的组合。 这些重复将通过额外的组或分析来增强，这些组或分析测试在原始研究方法框架内有意义的组合策略，或提供原始工作与新治疗组或两者的直接比较。