FACILITIES IN RESEARCH EXCELLENCE (FORE) IN SPINAL CORD INJURY (SCI) REPLICATION

这份合同的目标是(1)复制报道了促进脊髓损伤后康复的干预措施的有希望的已发表研究的结果，特别是促进亚急性或慢性损伤情况下的再生和干预措施的战略；(2)比较不同单独治疗和治疗组合的疗效。复制项目的总体合理性是确定潜在脊髓损伤治疗的重复性和稳健性，以便确定适合转化为临床前和最终临床试验的潜在治疗方法。我们建议进行至少5项涉及促进轴突再生的手法的研究，或10项旨在促进功能恢复的急性损伤后干预研究，或由独立的科学指导委员会选择的两项研究的组合。这些重复将增加额外的小组或分析，以测试在原始研究方法框架内有意义的组合策略，或提供原始工作与新治疗组的直接比较，或两者兼而有之。

The objectives for this contract are to (1) undertake replications of promising published studies reporting interventions to promote recovery after spinal cord injury focusing especially on strategies to promote regeneration and interventions in a sub-acute or chronic injury setting; (2) compare the efficacy of different individual treatments and treatment combinations. The overall reationale of the replication project is to determine the reproducibility and robustness of potential SCI treatments so as to identify potential therapies suitable for translation to pre-clinical and eventually clinical testing. We propose to carry out a minimum of 5 studies that involve manipulations to enhance axon regeneration or 10 studies of interventions during the acute post-injury period designed to enhance recovery of function, or a combination of the two as determined through selection by an independent Scientific Steering Committee. These replications will be augmented with additional groups or analyses that test either combination strategies that make sense within the framcwork of the methods of the original studies or provide a direct comparison of the original work with novel treatment groups or both.