CURCUMIN BINDING MODES IN HIV PROTEASE AND INTEGRASE ACTIVE SITES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类免疫缺陷病毒1型(HIV-1)是艾滋病的病原体。这个 HIV-1复制周期的独特性质为化疗干预提供了许多潜在的靶点。 姜黄Curuma Longa Linn.姜黄(姜科)是一种药用植物，广泛种植于亚洲热带地区。姜黄 姜黄素主要由姜黄素组成，约占75-95%，还有少量 去甲氧基姜黄素和双去甲氧基姜黄素。除了其强大的抗氧化活性外，各种相关活性 在生物系统中已经得到了广泛的研究。姜黄素已被证明具有抗炎作用， 胃肠活动，以及对各种蛋白激酶的抑制活性，包括蛋白激酶C和 磷酸化激活剂。据报道，姜黄素还可以抑制癌症的发生和癌细胞的生长。最近，姜黄素 据报道有抑制艾滋病毒复制的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS). The unique nature of the replication cycle of HIV-1 provides many potential targets for chemotherapeutic intervention. Curcuma longa Linn. or turmeric (Zingiberaceae) is a medicinal plant widely cultivated in tropical regions of Asia. Turmeric extract from the rhizomes commonly called curcumin is mainly composed of curcumin, about 75-95% and a small amount of demethoxy curcumin and bisdemethoxycurcumin. In addition to its potent antioxidant activity, various related activities in biological systems have been extensively investigated. Curcumin has been shown to exhibit anti-inflammatory, gastrointestinal activity, and inhibitory activity against a variety of protein kinases including protein kinase C and phosphoryl kinase. Curcumin is also reported to inhibit carcinogenesis and cancer growth. More recently, curcumin has been reported to inhibit HIV replication.