CURCUMIN BINDING MODES IN HIV PROTEASE AND INTEGRASE ACTIVE SITES

HIV 蛋白酶和整合酶活性位点中的姜黄素结合模式

• 批准号: 7358721
• 负责人: OPA VAJRAGUPTA
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358721
• 关键词: CURCUMIN; BINDING; MODES; HIV; PROTEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS). The unique nature of the replication cycle of HIV-1 provides many potential targets for chemotherapeutic intervention. Curcuma longa Linn. or turmeric (Zingiberaceae) is a medicinal plant widely cultivated in tropical regions of Asia. Turmeric extract from the rhizomes commonly called curcumin is mainly composed of curcumin, about 75-95% and a small amount of demethoxy curcumin and bisdemethoxycurcumin. In addition to its potent antioxidant activity, various related activities in biological systems have been extensively investigated. Curcumin has been shown to exhibit anti-inflammatory, gastrointestinal activity, and inhibitory activity against a variety of protein kinases including protein kinase C and phosphoryl kinase. Curcumin is also reported to inhibit carcinogenesis and cancer growth. More recently, curcumin has been reported to inhibit HIV replication.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。人类免疫缺陷病毒1型（Human immunodeficiency virus type 1，HIV-1）是获得性免疫缺陷综合征（acquired immunodeficiency syndrome，AIDS）的病原体。HIV-1复制周期的独特性质为化疗干预提供了许多潜在的靶点。姜黄或姜黄（姜黄科）是在亚洲热带地区广泛种植的药用植物。姜黄根茎提取物通常称为姜黄素，主要由姜黄素组成，约75-95%，以及少量的脱甲氧基姜黄素和双脱甲氧基姜黄素。除了其有效的抗氧化活性外，生物系统中的各种相关活性已被广泛研究。姜黄素已显示出抗炎、胃肠道活性和对多种蛋白激酶（包括蛋白激酶C和磷酰激酶）的抑制活性。姜黄素还被报道抑制致癌作用和癌症生长。最近，姜黄素被报道可以抑制HIV复制。