Women's Cancer

8.6.1摘要 女性癌症计划由医学博士Douglas Yee和医学博士Levi Down领导，有32名成员， 代表13个部门和4所学校。截至2007年9月30日，这些成员共有 660万美元，用于本预算期经同行审查、资助的研究项目。自2003年6月以来，他们的 研究产生了281份出版物，其中18%是方案内出版物，17%是方案间出版物。 这项计划是由乳腺癌计划的成员与 对妇科恶性肿瘤感兴趣的新成员。通过创建女性癌症计划，我们 加强现有协作，增强成员之间的互动，执行类似操作 主题研究，为临床研究人员提供额外的科学指导，并增强了我们的 翻译研究能力。该计划的科学目标是提高检测和 预防策略，癌症生物学基础研究机制，将研究成果转化为创新 临床策略。为了实现这些目标，该计划分为四个研究主题：1) 功能成像用于癌症的诊断、分期和治疗反应的预测，2)血管生成 乳腺癌和卵巢癌，3)基因表达，细胞信号，类固醇激素受体生物学，4) 癌症防治中的转化性研究。

8.6.1 ABSTRACT The Women's Cancer Program, led by Douglas Yee, M.D. and Levi Downs, M.D., has 32 members, representing 13 departments and four schools. As of September 30, 2007, these members have a total of $6.6 million in peer reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 281 publications, of which 18% were intra-programmatic and 17% were interprogrammatic. This program was created by combining the members of the Breast Cancer program with new members interested in gynecologic malignancies. By creating the Women's Cancer program, we strengthened existing collaborations, enhanced the interaction between members performing similarly themed research, provided additional scientific mentorship for clinical investigators, and enhanced our capacity for translational research. The scientific goals of the program are to improve detection and prevention strategies, study mechanisms basic to cancer biology, translate research findings into innovative clinical strategies. To achieve these goals, the program is organized into four research themes: 1) functional imaging for cancer diagnosis, staging, and prediction of response to therapy, 2) angiogensis in breast and ovarian cancer, 3) gene expression, cell signaling, and steroid hormone receptor biology, and 4) translational research in cancer prevention and treatmet.