Comparative Pathology

比较病理学

• 批准号: 7944883
• 负责人: Cathy S. Carlson
• 金额: $ 10.1万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-08 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944883
• 关键词: Agreement; Animal Cancer Model; Antibodies; Antigens; Apoptotic; Area; Blood; Bromodeoxyuridine; CD11 Antigens; CD19 gene; Cancer Center; Cancer Center Support Grant; Career Choice; Cathepsins B; Cells; Cessation of life; Clinical Chemistry; Collection; Communication; Comparative Pathology; Computer software; Consultations; Cytokeratin; Data; Detection; Development; Doctor of Philosophy; Documentation; Electronics; Evaluation; Experimental Designs; Experimental Pathology; Exposure to; Fluorescence; Formalin; Freezing; Frozen Sections; Future; Generations; Glucagon; Goals; Grant; Growth; Hematology; Hematoxylin and Eosin Staining Method; Histocytochemistry; Histology; Histopathology; Image; Image Analysis; Immunofluorescence Immunologic; Immunoglobulin G; Immunoglobulin M; Immunohistochemistry; Individual; Institutes; Insulin; Interleukin-7; Islet Cell Tumor; Label; Laboratories; Laboratory Animals; Lasers; Lesion; Licensing; Location; MCM2 gene; Macrophage-1 Antigen; Malignant Neoplasms; Manuscripts; Measurement; Methodology; Microscopic; Microscopy; Minnesota; Mission; PECAM1 gene; PTPRC gene; Paraffin; Pathologist; Pathology; Peroxidases; Phenotype; Preparation; Primates; Proliferating; Proteins; Proteomics; Protocols documentation; Publications; Relative (related person); Reporting; Research; Research Design; Research Personnel; Residencies; Resource Sharing; Resources; Rodent; Sampling; Scientist; Services; Site; Slide; Somatostatin; Staining method; Stains; Supervision; TdT-Mediated dUTP Nick End Labeling Assay; Techniques; Time; Tissues; Training; Transgenic Animals; Universities; VWF gene; Vascular Endothelial Growth Factors; Veterinary Medicine; Veterinary Pathology; Vimentin; Work; Writing; abstracting; animal tissue; anticancer research; base; bone; bone morphogenetic protein 4; caspase-3; college; design; digital imaging; experience; graduate student; impression; indexing; interest; member; morphometry; neoplastic cell; programs; protocol development; soft tissue; technique development; tissue fixing; tumor

9.2.1 ABSTRACT: COMPARATIVE PATHOLOGY Director: Cathy S. Carlson, DVM, PhD, Diplomats ACVP The Comparative Pathology Shared Resource provides expert veterinary pathology support for Cancer Center members who use laboratory animals in their research. Three full-time histotechnicians provide services that include generation of histolpgical sections from frozen and formalin fixed tissues, detection of antigens by immunohistochemistry, and development of new immunohistochemical protocols. Four boardcertified veterinary pathologists provide assistance with project design, evaluation of gross lesions, interpretation of changes in histological sections (both routine sections and immunohistbchemistry preparations), immunohistochemistry technique development, and imaging services. In the next grant cycle, histomorphometry services that will allow quantitation of gross and microscopic tissue changes as well as quantitation of immunohistochemistry results will be included. Having a dedicated group of veterinary pathologists with research expertise available to assist Cancer Center investigators with projects involving animal tissues provides a critical resource for some projects and is essential for publications involving pathological changes in tissues. The marked growth of this resource over the past 5 years is a testament to its value to the Cancer Center. Its location in the College of Veterinary Medicine at the University of Minnesota is easily accessible to Cancer Center investigators. Submission of samples and communication of results is further facilitated by a courier service, electronic communications, and the weekly on-site availability of one of the pathologists at the Cancer Center for consultation on projects. Cancer Center members are given priority for all services offered by the shared resource. Although projects are usually done on a first-come, first-served basis, an advisory board is in place to provide advice regarding prioritization of projects when this is needed.

9.2.1摘要：比较病理学 导演：凯西·S·卡尔森，DVM，博士，外交官ACVP 比较病理学共享资源为癌症提供兽医病理学专家支持 在研究中使用实验室动物的中心成员。三名全职组织技术人员提供 服务包括从冰冻和福尔马林固定的组织中生成组织切片，检测 通过免疫组织化学检测抗原，并开发新的免疫组织化学方案。四个获得认证的董事会 兽医病理学家在项目设计、肉眼病变评估、 组织切片(常规切片和免疫组织化学)变化的解释 准备)、免疫组织化学技术开发和成像服务。在下一个拨款周期中， 组织形态计量学服务，将允许量化大体和微观组织变化以及 免疫组织化学结果的量化将包括在内。拥有一支敬业的兽医团队 具有研究专业知识的病理学家可以协助癌症中心的研究人员进行以下项目 动物组织为一些项目提供了关键资源，对涉及以下内容的出版物也是必不可少的 组织中的病理变化。这种资源在过去5年中的显著增长证明了 它对癌症中心的价值。它位于加州大学兽医学院。 癌症中心的调查人员很容易到达明尼苏达州。样本的呈交及沟通 通过快递服务、电子通信和每周一次的现场宣传，进一步促进了成果的取得 让癌症中心的一位病理学家为项目提供咨询。癌症中心 成员优先使用共享资源提供的所有服务。尽管项目通常是 以先到先得的方式，设立了一个咨询委员会，就以下事项提供建议 在需要时确定项目的优先顺序。