Research Support Core C: Analytical Core

分析核心由两项研究支助活动组成：化学和生物统计。的目标 核心是提供必要的技术专长、一支支持人员和必要的研究工具 对将在本项目中研究的化学品进行定量评估，并评估暴露情况 以及与这些化学物质相关的风险。核心的化学组件将使用现有的 与布朗大学环境相关的仪器和技术支持的基础设施 化学设施，提供一套托管的实验室和分析设施，供 检测和量化考虑的有机和无机化合物的所有研究项目 危害人类健康。生物统计部分将提供统计方法和 为研究项目的实验设计和数据分析提供计算支持。专业知识 还将整合这两个组成部分，以确保对化学品和 他们的健康风险。分析核心中提出了五个具体目标：1)提供集中的 用于分析有机和无机化合物以及进行生物统计分析的设施；2)提供 负责核心化学部分管理的领导和一名领导 谁将负责生物统计能力；3)提供知识库和人员以 支持调查人员开发适当和创新的技术，以满足他们的特定需求 分析化学和生物统计学目标；4)提供消耗性用品、设备部件和 维护最先进的设施的计算能力；以及5)为学生提供培训， 使用核心设施的技术人员和研究人员。在最初的授权期内，资金可用于 加强专门侧重于检测和监测的仪器和设施的分析能力 有机化合物的定量，以及蒸气、液体和固体的汞分析。成就 AIMS 1-5将使用Brown的现有基础设施以及用于机器的知识库和支持人员 维护、计算分析和培训。这种管理模式在 初始资助期，并将继续支持本研究中的研究项目和分析 将在项目之间共享的设施

The Analytical Core is comprised of two research support activities; chemistry and biostatistics. The goals of the core are to provide technical expertise, a support staff, and research tools necessary to make quantitative assessments of the chemicals that will be studied in this project, and to evaluate the exposures and risks associated with these chemicals. The Chemistry component of the Core will use an existing infrastructure of instrumentation and technical support associated with Brown University's Environmental Chemistry Facility to provide a managed set of laboratories and analytical facilities that will be shared among all the research projects to detect and quantify organic and inorganic compounds that are considered hazardous to human health. The Biostatistical component will provide statistical methodology and computational support for experimental design and data analysis for the research projects. The expertise from the two components will also be integrated to ensure comprehensive analysis of the chemicals and their health risks. There are five specific aims proposed in the Analytical Core: 1) Provide centralized facilities for the analysis of organic and inorganic compounds, and for biostatistical analysis; 2) Provide a Leader who will be responsible for the management of the chemistry component of the Core and a Leader who will be responsible for the biostatistical capabilities; 3) Provide the knowledge base and personnel to support investigators in the development of appropriate and innovative techniques to satisfy their specific analytical chemistry and biostatiistical goals; 4) Provide expendable supplies, equipment parts, and the computational capabilities to maintain a state-of-the-art facility; and 5) Provide training for students, technicians, and researchers using core facilities. During the initial award period, funds were available to enhance the analytical capabilities of the instruments and facilities specifically focused on the detection and quantification of organic compounds, and mercury analysis of vapors, liquids, and solids. Accomplishment of Aims 1-5 will use the existing infrastructure at Brown, and a knowledge base and support staff for machine maintenance, computational analyses, and training. This model of management has worked well during the initial funding period and will continue to support the research projects in this study and the analytical facilities that will be shared among the projects